Protein Alignment CG4467 and RNPEP

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_064601.3
• Gene: RNPEP / 6051
• HGNCID: 10078
• Length: 650
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 105/563 - (18%)
• Similarity: 170/563 - (30%)
• Gaps: 193/563 - (34%)

  Fly   170 VEKETNFIVLHIQDLNVTEKA-IVTPGP-------KGYALKIVKVLEFPPRQQLYIEVKERLKKK 226
            |...:||....:..|::..:| ...|||       .|.|:..::.||.....:|.::....|:..
Human    25 VASASNFRAFELLHLHLDLRAEFGPPGPGAGSRGLSGTAVLDLRCLEPEGAAELRLDSHPCLEVT 89

  Fly   227 SNYTLNLRWYSKLNP-EPEGFYVDQY------------ESSNGVERLLAATVFRPNGA------- 271
            :......|..|:..| ||..||...:            :.....|||.....:|....
Human    90 AAALRRERPGSEEPPAEPVSFYTQPFSHYGQALCVSFPQPCRAAERLQVLLTYRVGEGPGVCWLA 154

  Fly   272 ---------------------RRAFPCFDEPHVRAPFRISV-FRDRFHIGLSNSIVHTTEDVG-- 312
                                 |..|||||.|.|:..:...: ..|.|...:|.|   |.|..|
Human   155 PEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSAS---TWEKRGPN 216

  Fly   313 -FYMGTGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSA---------------------AYIP 355
             |:         |....|:|:..:|..:.|.....:.|.:                     .::.
Human   217 KFF---------FQMCQPIPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLA 272

  Fly   356 TTP---------------APPGSGVGGKKSAQLNNYTQLKGKNPPVRNITALTHSLNVNLTP--- 402
            |..               .||....||.             :||      .||.     :||
Human   273 TGEKLFGPYVWGRYDLLFMPPSFPFGGM-------------ENP------CLTF-----VTPCLL 313

  Fly   403 ---RQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPSYTFYAPRDLLIRSSFILH 464
               |....|:....:.:|..||..|   :|......:.|        :|.||.|.:   |:.:..
Human   314 AGDRSLADVIIHEISHSWFGNLVTN---ANWGEFWLNEG--------FTMYAQRRI---STILFG 364

  Fly   465 TSRDVLE------YLQTWLDIS---YPLTKVDFVALPSLDRNMISSLGLVTLKTSFLTDPSSITS 520
            .:...||      .|:..:||:   .||.|:.....|.:|.:...:.........|::..:.:..
Human   365 AAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVG 429

  Fly   521 EQYQFSALRIAEAMVRQF-FGGITSRKVLK----------------------DVWL----WEGLI 558
            :|.||.:  ..:|.|.:| |..|.:...|.                      |.||    |...:
Human   430 DQDQFDS--FLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYL 492

  Fly   559 QYL--GIHALAPLQE---TWPLREMYLLKMATAALDIDAIQGW 596
            ..|  |...:.|.:|   .|...|:.:     .|::..||..|
Human   493 PDLSPGDSLMKPAEELAQLWAAEELDM-----KAIEAVAISPW 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	105/563 (19%)
		ERAP1_C	783..1078	CDD:463368
RNPEP	NP_064601.3	M1_LTA4H	24..484	CDD:341062	93/510 (18%)
		Leuk-A4-hydro_C	530..644	CDD:462686	1/1 (100%)