Protein Alignment CG4467 and Npepps

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_536320.1
• Gene: Npepps / 50558
• RGDID: 619962
• Length: 920
• Species: Rattus norvegicus
• Alignment Length: 1036
• Identity: 234/1036 - (22%)
• Similarity: 406/1036 - (39%)
• Gaps: 224/1036 - (21%)

  Fly   130 PFPWLEKMLPTSVRPLRYMVTIHPNLTTLDVKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVTP 194
            ||    :.|||.|.|:.|.:.:.|:|.....:|::.....|.:.||.||::..|:::...:....
  Rat    51 PF----ERLPTEVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPE 111

  Fly   195 GPK-------GYALKIVKV-LEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGFYVDQY 251
            |.:       .|..:..|| |.||...|           ....||.:.:..:||.:.:|||..:|
  Rat   112 GDEEIHATGFNYQNEDEKVTLSFPSTLQ-----------TGTGTLKIDFVGELNDKMKGFYRSRY 165

  Fly   252 ESSNGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMG 316
            .:..|..|..|.|.|....|||||||:|||.::|.|.||:...:..:.|||  ::..:...:...
  Rat   166 TTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSN--MNVIDRKPYPDD 228

  Fly   317 TGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKG 381
            ..|:...|..||.:....||:||.::.         ::.|.         .|....:..||
  Rat   229 ENLVEVKFARTPVMSTYLVAFVVGEYD---------FVETR---------SKDGVCVRVYT---- 271

  Fly   382 KNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPS 446
                                                ||.....||
  Rat   272 ------------------------------------PVGKAEQGK-------------------- 280

  Fly   447 YTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLK-TS 510
                          |.|..:...|.:.:.:.::.|||.|:|.:|:.......:.:.||||.: |:
  Rat   281 --------------FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETA 331

  Fly   511 FLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGL---IQYLGIHALAPLQET 572
            .|.||.:..|...|:.||.:...:..|:||.:.:.:....:||.||.   |:||.:....|..:.
  Rat   332 LLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDI 396

  Fly   573 WPLREMYLLKMATAALDIDAIQGWDSIMNGTSHDGNNEEFF----VQKTAAIFSMLHTAIGEDRF 633
            |   ..::....|.|.::||:.....|.....|....:|.|    ..|.|::..|||..||:..|
  Rat   397 W---TQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDF 458

  Fly   634 RGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPGFPLLTV----TKMGNSIS 694
            :..:..:|...:.:.|...|||. ..:.|:| |.|..:|..||.|.||||:.|    .:....:.
  Rat   459 KKGMNMYLTKFQQKNAATEDLWE-SLESASG-KPIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLK 521

  Fly   695 ISQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKWIFPVTYVT-- 757
            :||:.|       .....|.|.          |.|                  :|:.|:|..|
  Rat   522 LSQKKF-------CASGPYVGE----------DCP------------------QWMVPITISTSE 551

  Fly   758 DINNVSETLWMQNVDVTFNVPENVK---WIKVNAIQNGYYRVVYNDDNWASL---IEELAANPNR 816
            |.|.....:.|...:::. |.:|||   |:|:|....|:||..|:.....||   |.:|:..|
  Rat   552 DPNQAKLKILMDKPEMSV-VLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPP-- 613

  Fly   817 FTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEKWRRILKYSECFLM 881
               .||||:.:|.|:|..|.::.....:.:::...:|.:|...:....:|.....:|.:::.:..
  Rat   614 ---VDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEE 675

  Fly   882 LSEFIKMKISTVMEKVGWS---DDGDVATRLLRPEVLLASVLWEDID------SITKAKNMLNQY 937
            :.||:|...|.:.|::||.   .:|.:       :.||..::...:.      ::.:|:....::
  Rat   676 IQEFVKDVFSPIGERLGWDPKPGEGHL-------DALLRGLVLGKLGKAGHKATLEEARRRFKEH 733

  Fly   938 LYYNGTAI-PPNLREVVYTGSILSGEYIYWQHCWERFVNLQRTSETFVERMQLLRALGRTKDAWL 1001
            :  .|..| ..:||..||...:..|:    ....:..:.|.:.::...|:.::.|.||.|....|
  Rat   734 V--EGKQILSADLRSPVYLTVLKHGD----GTTLDIMLKLHKQADMQEEKNRIERVLGATLSPEL 792

  Fly  1002 QNRLLSHVTMLPTEEV-----VQVLKAIA-GTPTGGAMACRFLQAKWFELEKRLGPGTISFAKVI 1060
            ..::|   |...:|||     |.|:..:| |:..|...|.:|::..|.||..|...|.:     |
  Rat   793 IQKVL---TFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFL-----I 849

  Fly  1061 SAITQYGATKFDYDELKSLVHRFGRGHGMSVLNMTLSSVASNV----EWVARSQTSLYKWV 1117
            |.:.:.....|..|::...|..|...|.......|:.....|:    .|:.|...|:::::
  Rat   850 SRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDADSIHQYL 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	124/547 (23%)
		ERAP1_C	783..1078	CDD:463368	70/313 (22%)
Npepps	NP_536320.1	M1_APN-Q_like	62..500	CDD:341064	124/547 (23%)
		ERAP1_C	579..892	CDD:463368	74/338 (22%)