Protein Alignment CG4467 and npepps

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001157499.1
• Gene: npepps / 407726
• ZFINID: ZDB-GENE-060524-3
• Length: 872
• Species: Danio rerio
• Alignment Length: 1026
• Identity: 228/1026 - (22%)
• Similarity: 404/1026 - (39%)
• Gaps: 217/1026 - (21%)

  Fly   138 LPTSVRPLRYMVTIHPNLTTLDVKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVTPGPK----- 197
            |||.|.|:.|.:.:.|:|.....:|::...:.|.:.||.||::..|:::...:.|..|.:
Zfish    10 LPTDVYPVNYGLRLKPDLVDFTFEGKLEAAVEVTQGTNQIVMNCADIDIITASFVPDGGEEINAT 74

  Fly   198 --GYALKIVKV-LEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGFYVDQYESSNGVER 259
              .|..:..|| |.||...|           |.:.:|.:.:..:||.:.:|||..:| ||:|..|
Zfish    75 GFNYQNEDEKVTLCFPSTLQ-----------KGSGSLKIDFVGELNDKMKGFYRSKY-SSSGEVR 127

  Fly   260 LLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMGTGLLRDDF 324
            ..|.|.|....|||||||:|||.::|.|.|::...:..:.|||  ::..:...:.....|:...|
Zfish   128 YAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSN--MNVVDRKPYAEDQSLVEVKF 190

  Fly   325 IETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKGKNPPVRNI 389
            ..||.:....||:|:.::.....|.|.........|.|....||
Zfish   191 ATTPIMSTYLVAFVIGEYDFVESQSSDGVTVRVYTPVGKAEQGK--------------------- 234

  Fly   390 TALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPSYTFYAPRD 454
                                                                             
Zfish   235 ----------------------------------------------------------------- 234

  Fly   455 LLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLK-TSFLTDPSSI 518
                  |.|..:...|.:.:.:..:.|||.|:|.:|:.......:.:.||||.: |:.|.||.:.
Zfish   235 ------FALEVATKTLPFYKDYFSVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNS 293

  Fly   519 TSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGL---IQYLGIHALAPLQETWPLREMYL 580
            .:...|:.||.:...:..|:||.:.:.:....:||.||.   |:||.:....|..:.|   ..::
Zfish   294 CASSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIW---TQFV 355

  Fly   581 LKMATAALDIDAIQGWDSIMNGTSHDGNNEEFF----VQKTAAIFSMLHTAIGEDRFRGCLGSFL 641
            ....|.|||:||:.....|.....|....:|.|    ..|.|::..|||..||::.||..:.::|
Zfish   356 SADYTRALDLDALDNSHPIEVDVGHPSEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYL 420

  Fly   642 KVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPGFPLLTVTKMGNS----ISISQRPFRP 702
            ...:.:.|...|||. |.::|:| |.|..:|..||.|.|||::.|.:..:.    :.|||:.|..
Zfish   421 LKFQHKNASTEDLWE-CLEQASG-KPIAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCA 483

  Fly   703 AEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKWIFPVTYVT--DINNVSET 765
            :                 ...|..|.|:                  |:.|::..|  |.:.....
Zfish   484 S-----------------GPRNDEDCPN------------------WMVPISICTSEDPSCTKTK 513

  Fly   766 LWMQNVDVTFNV----PENVKWIKVNAIQNGYYRVVYNDDNWASL---IEELAANPNRFTSEDRL 823
            :.:...:.|.|:    |::  |||:|....|:||:.|:.....||   |.:|...|     .|||
Zfish   514 ILLDQPETTVNITNVAPDH--WIKINPGTVGFYRIQYSSAMLESLLPGIRDLTLLP-----VDRL 571

  Fly   824 GMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEKWRRILKYSECFLMLSEFIKM 888
            |:.:|.|:|..|.::.....:.:::...:|.:|...:....:|.....:|.:::....:.|||:.
Zfish   572 GLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDLSCNLGVLSSLLSHTDFHEDIQEFIRD 636

  Fly   889 KISTVMEKVGWSDDGDVATRLLRPEVLLASVLWEDID------SITKAKNMLNQYLYYNGTAI-P 946
            ..:.:..|:||    |..|.....:.||..::...:.      ::.:|:....:::  .|..| .
Zfish   637 LFTPIGMKLGW----DSRTGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFREHV--EGKQILS 695

  Fly   947 PNLREVVYTGSILSGEYIYWQHCWERFVNLQRTSETFVERMQLLRALGRTKDAWLQNRLLSHVTM 1011
            .:||..||...:..|:    ....:..:.|.:.::...|:.::.|.||......|..|:|:...
Zfish   696 ADLRSPVYLTVLKHGD----STTLDTMLKLHKQADMQEEKNRIERVLGAIPAPDLIQRVLNFAL- 755

  Fly  1012 LPTEEV-----VQVLKAIAGTPTGGAMAC-RFLQAKWFELEKRLGPGTISFAKVISAITQYGATK 1070
              :|||     |.|:..:||:...|..|. :|::..|.||..|...|.:     ||.:.:.....
Zfish   756 --SEEVRPQDTVSVIGGVAGSSKQGRKAAWKFVKDNWEELHNRYQGGFL-----ISRLIKLTVDG 813

  Fly  1071 FDYDELKSLVHRFGRGHGMSVLNMTLSSVASNV----EWVARSQTSLYKWV 1117
            |..|::.:.|..|...|.......|:.....|:    .|:.|....:::::
Zfish   814 FAIDKMAAEVKSFFESHHAPAAERTVQQCCENILLNAAWLKRDADDIHQYL 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	126/547 (23%)
		ERAP1_C	783..1078	CDD:463368	70/310 (23%)
npepps	NP_001157499.1	M1_APN-Q_like	17..454	CDD:341064	126/547 (23%)
		ERAP1_C	533..846	CDD:463368	74/335 (22%)