Protein Alignment CG4467 and LTA4H

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_000886.1
• Gene: LTA4H / 4048
• HGNCID: 6710
• Length: 611
• Species: Homo sapiens
• Alignment Length: 724
• Identity: 120/724 - (16%)
• Similarity: 220/724 - (30%)
• Gaps: 270/724 - (37%)

  Fly   139 PTSV---RPLRYMVTIHPNLTTLDVKGQVTIDLHVEKETNF--IVLHIQDLNVTEKAIVT----- 193
            |.||   :.|....::.....||.....:|:.   .:|.|.  :||..:||.: ||.::.
Human    13 PASVCRTKHLHLRCSVDFTRRTLTGTAALTVQ---SQEDNLRSLVLDTKDLTI-EKVVINGQEVK 73

  Fly   194 ------PGPKGYALKIVKVLEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGFYVDQYE 252
                  ...||..::|...:.....|::.||:......||:   .|:|   |.|          |
Human    74 YALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSS---ALQW---LTP----------E 122

  Fly   253 SSNGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMGT 317
            .::|.|.....:..:....|...||.|.|.|:..:...|...:..:.|.::|
Human   123 QTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAI------------- 174

  Fly   318 GLLRD--------------DFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGK 368
               ||              .||:..|:|...:|.|                          ||..
Human   175 ---RDGETPDPEDPSRKIYKFIQKVPIPCYLIALV--------------------------VGAL 210

  Fly   369 KSAQLNNYTQLKGKNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSL 433
            :|.|:.                           ||          |..|
Human   211 ESRQIG---------------------------PR----------TLVW---------------- 222

  Fly   434 SQSTGSSIKRAPSYTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLT--KVDFVAL-PSLD 495
                             :.::.:.:|::....:..:|:..:   |:..|..  :.|.:.| ||..
Human   223 -----------------SEKEQVEKSAYEFSETESMLKIAE---DLGGPYVWGQYDLLVLPPSFP 267

  Fly   496 RNMISSLGLVTLKTSFLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGLIQY 560
            ...:.:..|..:..:.|....|:::.        ||..:...:.|.:.:.|.....||.||...|
Human   268 YGGMENPCLTFVTPTLLAGDKSLSNV--------IAHEISHSWTGNLVTNKTWDHFWLNEGHTVY 324

  Fly   561 LGIHALAPLQETWPLREMYLLKMATAALDIDAIQGWDSIMNGTSHDGNNEEF------------- 612
            |..|....|             ........:|:.||..:.|.....|....|
Human   325 LERHICGRL-------------FGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPD 376

  Fly   613 -------FVQKTAAIFSMLHTAIGEDRFRGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKD 670
                   :.:..|.:|.:.....|.:.|.|.|.::::...:::. .||.|             ||
Human   377 VAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI-TTDDW-------------KD 427

  Fly   671 MM----------------TLWTHQPGFPLL----TVTKMGNSISISQRPFRPAEFLAIHDDSYDG 715
            .:                ..|.:.||.|.:    .:|.....|::|||      ::...:|  |.
Human   428 FLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQR------WITAKED--DL 484

  Fly   716 NNYNKT---TLNATDMPSTVATTTQGSKHKVAPHMKWIFPVTYVTDINNVSETLWMQNVDVTFNV 777
            |::|.|   .|::..:...:|.|.|.     ||     .|:.::..:..|.....:.|.::.|
Human   485 NSFNATDLKDLSSHQLNEFLAQTLQR-----AP-----LPLGHIKRMQEVYNFNAINNSEIRF-- 537

  Fly   778 PENVKWIKV 786
                :|:::
Human   538 ----RWLRL 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	93/597 (16%)
		ERAP1_C	783..1078	CDD:463368	1/4 (25%)
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	120/724 (17%)