Protein Alignment CG4467 and LNPEP

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: XP_054208557.1
• Gene: LNPEP / 4012
• HGNCID: 6656
• Length: 1097
• Species: Homo sapiens
• Alignment Length: 1175
• Identity: 286/1175 - (24%)
• Similarity: 486/1175 - (41%)
• Gaps: 270/1175 - (22%)

  Fly    22 DGIELEPLG--------GEKCDKDKDKDKEKQTN--GVTFGGESSGGRQTRTGV-----AVCS-- 69
            |.:|.||.|        ||...::.::|.|....  |::|...|||.|.:.||.     ..||
Human   114 DEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVP 178

  Fly    70 QRRALLVAGIVLGSLLLTAIIIAYAGPQNDCS-----CGSKTVS-GYETDEENNTQPFNPIATNG 128
            ..|.::|...|: .:.::.|::.|..|:  |:     |..|..| |.       .|||   ||||
Human   179 SARTMVVCAFVI-VVAVSVIMVIYLLPR--CTFTKEGCHKKNQSIGL-------IQPF---ATNG 230

  Fly   129 EPFPWLEKMLPTSVRPLRYMVTIHPNLTTLDVKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVT 193
            :.|||.:..|||:|.||||.:::|||||::..:|.|||.:...:.|..|:||....|::....::
Human   231 KLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMS 295

  Fly   194 PGPKGYAL----KIVKVLEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGFYVDQYESS 254
                  |:    |..::||:....|:.|...|.|....||||.:.:.:.::....|||...|...
Human   296 ------AVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDE 354

  Fly   255 NGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSN-----SIVHTTEDVGFY 314
            :..::..|||.|.|..||.||||||||..:|.|.|.:.||..:..|||     |:|
Human   355 SNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVV--------- 410

  Fly   315 MGTGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQL 379
            :..||::|:|.|:..:....||::|.:.:
Human   411 LDDGLVQDEFSESVKMSTYLVAFIVGEMK------------------------------------ 439

  Fly   380 KGKNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRA 444
                               ||:...|.|:|
Human   440 -------------------NLSQDVNGTLV----------------------------------- 450

  Fly   445 PSYTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLK- 508
               :.||..:.:.:..:.|.|:..:||:.|.:.:|.|||.|:|.||:|..:...:.:.||:|.:
Human   451 ---SIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFRE 512

  Fly   509 --------TSFLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGLIQYLGIHA 565
                    ||.:.|...:|.        .||..:..|:||.:.:.|...|:||.||...::...:
Human   513 ETLLYDSNTSSMADRKLVTK--------IIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFS 569

  Fly   566 LAPLQETWPLREMYL-LKMATAALDIDAIQGWDSIMNGTSHDGNNEEFFVQ----KTAAIFSMLH 625
            |..:.:.....|.:| .:..|  :..|::.....|.:........||.|..    |.:::..||.
Human   570 LEKIFKELSSYEDFLDARFKT--MKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLK 632

  Fly   626 TAIGEDRFRGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPGFPLLTVTKMG 690
            |.:.||.|:..:..:|..:.:.:.:..|||....:..|.:.::|.||..||.|.||||:||.|.|
Human   633 TYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKG 697

  Fly   691 NSISISQRPFRPAEFLAI------HDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKW 749
            ..:.|.|..|    ||.:      .|.||                                  .|
Human   698 KELFIQQERF----FLNMKPEIQPSDTSY----------------------------------LW 724

  Fly   750 IFPVTYVTDINNVSETLWMQNVDV------TFNVPENVKWIKVNAIQNGYYRVVYNDDNWASLIE 808
            ..|::|||:..|.|:   .|:|.:      ..|:.|.|.|:|||...||||.|.|.||:|.:||.
Human   725 HIPLSYVTEGRNYSK---YQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIH 786

  Fly   809 ELAANPNRFTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALAL-------RHL 866
            :|..||...:.:||..::::.|.|.....:|.:...::|.||.:|.|..|:..||       ..|
Human   787 QLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLL 851

  Fly   867 EKWRRILKYSECFLMLSEFIKMKISTVMEKVGWSDDGDVATRLLRPEVLLASVLWEDIDSITKAK 931
            ||    |.|.:....|...:...:...:::..|:|:|..:.|.||..:|..:......:..|.|.
Human   852 EK----LGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM 912

  Fly   932 NMLNQYLYYNGT-AIPPNLREVVYT--------GSILSGEYIYWQHCWERFVNLQRTSETFVERM 987
            .:.:.::..||| ::|.::...|:.        .|.|.|:||              :..:..|:.
Human   913 KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYI--------------SIGSEAEKN 963

  Fly   988 QLLRALGRTKDA----WLQNRLLSHVTMLPTEEVVQVLKAIAGTPTGGAMACRFLQAKWFELEKR 1048
            ::|.||..::|.    ||....|:. ....|:::..:::.:.....|..:|..|::..|.:|.::
Human   964 KILEALASSEDVRKLYWLMKSSLNG-DNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQK 1027

  Fly  1049 LGPGTISFAKVISAITQYGATKFDYDELKSLVHRFGRG-HGMSVLNMTLSSVASNVEWVARSQTS 1112
            ...|:.:...:::..|...:||....|:::........ ..:..:...|..:..|::|:.::..|
Human  1028 FPLGSYTVQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS 1092

  Fly  1113 LYKWV 1117
            |..|:
Human  1093 LTWWL 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	130/554 (23%)
		ERAP1_C	783..1078	CDD:463368	75/314 (24%)
LNPEP	XP_054208557.1	M1_APN-Q_like	247..684	CDD:341064	130/554 (23%)
		ERAP1_C	761..1081	CDD:463368	76/338 (22%)