Protein Alignment CG4467 and anpepb.1

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001082794.1
• Gene: anpepb.1 / 322533
• ZFINID: ZDB-GENE-030131-1253
• Length: 965
• Species: Danio rerio
• Alignment Length: 1138
• Identity: 248/1138 - (21%)
• Similarity: 445/1138 - (39%)
• Gaps: 281/1138 - (24%)

  Fly    72 RALLVAGIVLGSLLLTAII---IAYAGPQNDCSCGSKTVSGYETDEENNTQPFNPI----ATNGE 129
            :.|.:.|||:|:..:..||   :.|:..::         ...|.:.:..|....|.    ||...
Zfish     9 KTLGIVGIVIGAGAVATIIALSVVYSQEKS---------KNNEIENQQTTTTKGPTTNVPATTNI 64

  Fly   130 PF------PWLEKMLPTSVRPLRYMVTIHPNLT-----TLDVKGQVTIDLHVEKETNFIVLHIQD 183
            |.      ||.:..||.::.|..|.||:.|.|.     .....|..::.....:.|:.|::|...
Zfish    65 PTTVPSNEPWDQWRLPQTLSPETYKVTLWPRLQKNAEGLYIFTGDSSVVFRCVENTDLILIHSNK 129

  Fly   184 LNVTEKAIV-----TPGPKGYALKIVKVLEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEP 243
            |.:.:...:     .|.|     .||....:|..|.:.|.:...|....:|.|...:..:|:.:.
Zfish   130 LTIKDSTTLKALGGNPAP-----NIVSTKMYPKTQYMAIWLDRELTAGESYELYTEFVGELSDDL 189

  Fly   244 EGFYVDQYESSNGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTT 308
            .|||..:|...|||.:::|.|..:...||:||||||||.::|.|.|.:..|...:.|||.:|  .
Zfish   190 GGFYRSEYYDENGVLKVVATTQMQATDARKAFPCFDEPAMKAVFNIVLLHDPGTVALSNGVV--I 252

  Fly   309 EDVGFYM-GTGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQ 372
            |::...: |..|.:..|..|..:....:|::||:|
Zfish   253 EEIPVTVDGISLTKTTFAPTEKMSTYLLAFIVSEF------------------------------ 287

  Fly   373 LNNYTQLKGKNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQST 437
              .|.:.|..:..:| |.|...:::.|
Zfish   288 --TYIEQKLDDLQIR-IFARKEAIDAN-------------------------------------- 311

  Fly   438 GSSIKRAPSYTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSL 502
                                :..:.|..:..:|.:.:.:.:.||||.|.|.:|||..:...:.:.
Zfish   312 --------------------QGEYALSVTGKILRFFEEYYNSSYPLPKSDQIALPDFNAGAMENW 356

  Fly   503 GLVTLK-TSFLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGL---IQYLGI 563
            ||:|.: |:.|.|....::...:.....||..:..|:||.:.:.:...|:||.||.   ::|||.
Zfish   357 GLITYRETALLYDEEMSSNGNKERVVTVIAHELAHQWFGNLVTIRWWNDLWLNEGFASYVEYLGA 421

  Fly   564 HALAPLQETWPLREMYLLKMATAALDIDAIQGWDSIMNGTSHDGNNEEFFVQ------------- 615
            ....||   |.::::.:|........|||:        .:||..:::|..||
Zfish   422 DEAEPL---WNIKDLIVLNDVHRVFAIDAL--------ASSHPLSSKEEDVQRPEQISEVFDTIS 475

  Fly   616 --KTAAIFSMLHTAIGEDRFRGCLGSFLKVNRFRTAEPTDLWTICTKKANGS-----KNIKDMMT 673
              |.|::..||...:.||.|...|.::|:..:|.....||||.......:.:     :::||:|.
Zfish   476 YSKGASVLRMLSNFLSEDVFTQGLRTYLEHFKFNNTVYTDLWDHLQMAVDETGTELPRSVKDIMD 540

  Fly   674 LWTHQPGFPLLTVTKMGNSIS--ISQRPF--------RPAEFLAIHDDSYDGNNYNKTTLNATDM 728
            .|..|.|||::|:    |:::  |||..|        .|:||           ||
Zfish   541 RWVLQMGFPVVTI----NTVTGQISQEHFLLDPETKPEPSEF-----------NY---------- 580

  Fly   729 PSTVATTTQGSKHKVAPHMKWIFPVTYVTDINNVSETLWMQNVDVTF-NVPENV-KWIKVNAIQN 791
                               :|..|:|: |....:....|:...:..| ::..|. :|:..|....
Zfish   581 -------------------EWFVPITW-TKNEAIKPQYWLLQKNTQFDDMKTNANEWVLANINTV 625

  Fly   792 GYYRVVYNDDNWASLIEELAANPNRFTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHY 856
            |||||.|::.||..|:..|..:.......:|..::.|||.|..|.::...:.:...::|..||.|
Zfish   626 GYYRVNYDEQNWERLLNALQTSRESIPVINRAQLIDDAFNLAKAGIIKTTLALRTTEFLDVETEY 690

  Fly   857 GPMALALRHLEKWRRILKYSECFLMLSEFIKMKISTVMEKVGWSDDGDVATRLLRPEVLLASVLW 921
            .|...||.:|:.:..:...||.:..:..:|:.:::.:.|......|                  |
Zfish   691 MPWQSALNNLDYFYLMFDRSEVYGHMQAYIRKQVTPLFEYFTELTD------------------W 737

  Fly   922 EDI-DSITKAKNMLNQYL--------------------YYNGTAIPP---NLREVVYTGSILSGE 962
            :.: |:.|:..|.:|...                    :.|...:.|   |||..||..:|.:|.
Zfish   738 QGVPDNHTEQYNQVNALRVACSIGLKNCTDLVTSWFGEWMNNEDVNPIHANLRSTVYCSAIAAGG 802

  Fly   963 YIYWQHCWERFVNLQRTSETFVERMQLLRALGRTKDAWLQNRLLSH---VTMLPTEEVVQVLKAI 1024
            ...|:..|:.|   ::|| ...|:.:|..|:......||.||.|.:   ...:..::....:.:|
Zfish   803 AEEWEFAWKMF---EKTS-VASEKDKLRAAMACATQPWLLNRYLEYTLDANKIRKQDATSTIVSI 863

  Fly  1025 AGTPTGGAMACRFLQAKWFELEKRLGPGTISFAKVISAITQYGATKFDYDELKSLV------HRF 1083
            |....|.::|..|::|.|..:..:.|.|:.||:.:|:.:|:..:|:|   |||.|:      ...
Zfish   864 ASNVGGQSLAWDFVRANWEYIFNQYGGGSFSFSNLINGVTKRFSTEF---ELKQLMQFKEDNEHI 925

  Fly  1084 GRGHGMSVLNMTLSSVASNVEWVARSQTSLYKW 1116
            |.|.|...:..::....:|::||.:::..:.:|
Zfish   926 GFGSGSLAIQQSIERTKANIKWVEQNKADVLQW 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	123/566 (22%)
		ERAP1_C	783..1078	CDD:463368	75/321 (23%)
anpepb.1	NP_001082794.1	M1_APN-Q_like	88..544	CDD:341064	123/564 (22%)
		ERAP1_C	617..943	CDD:463368	80/350 (23%)