Protein Alignment CG4467 and Lta4h

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001025202.1
• Gene: Lta4h / 299732
• RGDID: 1311333
• Length: 611
• Species: Rattus norvegicus
• Alignment Length: 698
• Identity: 119/698 - (17%)
• Similarity: 212/698 - (30%)
• Gaps: 256/698 - (36%)

  Fly   157 TLDVKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVTPGPKGYALKIVKVLEFPPRQQLYIEVKE 221
            |||.|     ||.:||    :|::.|::..|...  :.|.||..::|...:.....|::.||:..
  Rat    54 TLDTK-----DLTIEK----VVINGQEVKYTLGE--SQGYKGSPMEISLPIALSKNQEVVIEISF 107

  Fly   222 RLKKKSNYTLNLRWYSKLNPEPEGFYVDQYESSNGVERLLAATVFRPNGARRAFPCFDEPHVRAP 286
            ....||:   .|:|   |.|          |.::|.:.....:..:....|...||.|.|.|:..
  Rat   108 ETSPKSS---ALQW---LTP----------EQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLT 156

  Fly   287 FRISVFRDRFHIGLSNSIVHTTEDVGFYMGTGLLRDD--------------FIETPPLPADAVAW 337
            :...|...:..:.|.::|                ||.              |.:..|:|...:|.
  Rat   157 YTAEVSVPKELVALMSAI----------------RDGEAPDPEDPSRKIYRFNQRVPIPCYLIAL 205

  Fly   338 VVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKGKNPPVRNITALTHSLNVNLTP 402
            |                          ||..:|.|:.                           |
  Rat   206 V--------------------------VGALESRQIG---------------------------P 217

  Fly   403 RQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPSYTFYAPRDLLIRSSFILHTSR 467
            |          |..|                                 :.::.:.:|::....:.
  Rat   218 R----------TLVW---------------------------------SEKEQVEKSAYEFSETE 239

  Fly   468 DVLEYLQTWLDISYPLT--KVDFVAL-PSLDRNMISSLGLVTLKTSFLTDPSSITSEQYQFSALR 529
            .:|:..:   |:..|..  :.|.:.| ||.....:.:..|..:..:.|....|:::.
  Rat   240 SMLKIAE---DLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNV-------- 293

  Fly   530 IAEAMVRQFFGGITSRKVLKDVWLWEGLIQYLGIHALAPLQETWPLREMYLLKMATAALDIDAIQ 594
            ||..:...:.|.:.:.|.....||.||...||..|....|             .........|:.
  Rat   294 IAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRL-------------FGEKFRHFHALG 345

  Fly   595 GWDSIMNGTSHDGNNEEF--------------------FVQKTAAIFSMLHTAIGEDRFRGCLGS 639
            ||..:.|.....|.:..|                    :.:..|.:|.:.....|.:.|.|.|.:
  Rat   346 GWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKA 410

  Fly   640 FLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTL--------WTHQPGFPLL----TVTKMGNS 692
            :::...:::. .||.|     |:....:.||.:.|        |.:.||.|.:    .||.....
  Rat   411 YVEKFSYQSV-TTDDW-----KSFLYAHFKDKVDLLNQVDWNAWLYAPGLPPVKPNYDVTLTNAC 469

  Fly   693 ISISQRPFRPAE----FLAIHD----DSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKW 749
            |::|||.....|    ..:|.|    .|:..|.:....|....:|              ..|:|.
  Rat   470 IALSQRWVTAKEEDLNSFSIEDLKDLSSHQLNEFLAQVLQKAPLP--------------LGHIKR 520

  Fly   750 IFPVTYVTDINNVSETLWMQNVDVTFNVPENVKWIKVNAIQNGYYRVV 797
            :..|.....||         |.::.|      :|::: .||:.:...:
  Rat   521 MQEVYNFNAIN---------NSEIRF------RWLRL-CIQSKWEEAI 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	93/564 (16%)
		ERAP1_C	783..1078	CDD:463368	3/15 (20%)
Lta4h	NP_001025202.1	leuko_A4_hydro	6..608	CDD:274120	119/698 (17%)