Protein Alignment CG4467 and ANPEP

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001141.2
• Gene: ANPEP / 290
• HGNCID: 500
• Length: 967
• Species: Homo sapiens
• Alignment Length: 1122
• Identity: 261/1122 - (23%)
• Similarity: 449/1122 - (40%)
• Gaps: 238/1122 - (21%)

  Fly    72 RALLVAGIVLGSLLLTAII---IAYAGPQNDCSCGSKTVSGYETDEENNTQPFNPIATNGEPFPW 133
            ::|.:.||:||...:..||   :.|:..:|. :..|..|:.........|.|.: ..|..:...|
Human     9 KSLGILGILLGVAAVCTIIALSVVYSQEKNK-NANSSPVASTTPSASATTNPAS-ATTLDQSKAW 71

  Fly   134 LEKMLPTSVRPLRYMVTIHPNLTTLD-----VKGQVTIDLHVEKETNFIVLHIQDLNVT---EKA 190
            ....||.:::|..|.||:.|.||..|     .||..|:....::.|:.|::|.:.||.|   ...
Human    72 NRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHR 136

  Fly   191 IVTPGPKGYALKIVKVLEF-PPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGFYVDQYESS 254
            :|..|..|.....:...|. .|.:.|.:.:|..|.|.|.|.::..:..:|..:..|||..:|...
Human   137 VVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEG 201

  Fly   255 NGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSI-----VHTTEDVGFY 314
            | |.:::|.|..:...||::|||||||.::|.|.|::...:....|||.:     ....||..:.
Human   202 N-VRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWN 265

  Fly   315 MGTGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQL 379
            :      .:|..||.:....:|::||:|                                :|.:.
Human   266 V------TEFHTTPKMSTYLLAFIVSEF--------------------------------DYVEK 292

  Fly   380 KGKNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRA 444
            :..|..:..|.|                  :|:...|      |:|
Human   293 QASNGVLIRIWA------------------RPSAIAA------GHG------------------- 314

  Fly   445 PSYTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLK- 508
                           .:.|:.:..:|.:.....|..|||.|.|.:.||..:...:.:.||||.:
Human   315 ---------------DYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRE 364

  Fly   509 TSFLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGL---IQYLGIHALAPLQ 570
            .|.|.||.|.:|...:.....||..:..|:||.:.:.:...|:||.||.   ::|||.....|
Human   365 NSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEP-- 427

  Fly   571 ETWPLREMYLLKMATAALDIDAIQGWDSIMNGTSH---DGNNEEFF----VQKTAAIFSMLHTAI 628
             ||.|:::.:|......:.:||:.....:....|.   .....|.|    ..|.|::..||.:.:
Human   428 -TWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFL 491

  Fly   629 GEDRFRGCLGSFLKVNRFRTAEPTDLWTICTKKANGSK-----NIKDMMTLWTHQPGFPLLTV-T 687
            .||.|:..|.|:|....::.....:||....:..|...     .::|:|..||.|.|||::|| |
Human   492 SEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDT 556

  Fly   688 KMGNSISISQRPF---------RPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKV 743
            ..|   ::||..|         ||:||           ||
Human   557 STG---TLSQEHFLLDPDSNVTRPSEF-----------NY------------------------- 582

  Fly   744 APHMKWIFPVTYVTDINNVSETLWMQNVDV-----TFNVPENVKWIKVNAIQNGYYRVVYNDDNW 803
                .||.|:|.:.| ....:..|:  :||     .|:...| :|:.:|....|||||.|:::||
Human   583 ----VWIVPITSIRD-GRQQQDYWL--IDVRAQNDLFSTSGN-EWVLLNLNVTGYYRVNYDEENW 639

  Fly   804 ASLIEELAANPNRFTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEK 868
            ..:..:|..:.:.....:|..:::|||.|..|:.:|..:.:|...:|..|..|.|...||..|..
Human   640 RKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSY 704

  Fly   869 WRRILKYSECFLMLSEFIKMKISTVM-----EKVGWSDDGDVATRLLRPEVLLASVLWEDIDSIT 928
            ::.:...||.:..:..::|.:::.:.     ....|.:         .||.|:..  :.::::|:
Human   705 FKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWRE---------IPENLMDQ--YSEVNAIS 758

  Fly   929 KA------------KNMLNQYLYY-NGTAIPPNLREVVYTGSILSGEYIYWQHCWERFVNLQRTS 980
            .|            ..:..|::.. |...|.||||..||..:|..|....|...||:|.|
Human   759 TACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRN----- 818

  Fly   981 ETFVERMQLLR-ALGRTKDAWLQNRLLSHV---TMLPTEEVVQVLKAIAGTPTGGAMACRFLQAK 1041
            .|.|.....|| ||..:|:.|:.||.||:.   .::..::....:.:|.....|..:...|:|:.
Human   819 ATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSN 883

  Fly  1042 WFELEKRLGPGTISFAKVISAITQYGATKFDYDELKSLV---HRFGRGHGMSVLNMTLSSVASNV 1103
            |.:|....|.|:.||:.:|.|:|:..:|:::..:|:...   ...|.|.|...|...|....:|:
Human   884 WKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANI 948

  Fly  1104 EWVARSQTSLYKWVEGN 1120
            :||..::..:.:|...|
Human   949 KWVKENKEVVLQWFTEN 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	127/561 (23%)
		ERAP1_C	783..1078	CDD:463368	78/316 (25%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		7/36 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..62		4/22 (18%)
		Metalloprotease	69..967		247/1060 (23%)
		M1_APN-Q_like	84..545	CDD:341064	127/560 (23%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485	288..295		1/6 (17%)
		ERAP1_C	619..946	CDD:463368	83/342 (24%)