Protein Alignment CG4467 and pam-1

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001023210.1
• Gene: pam-1 / 177528
• WormBaseID: WBGene00003914
• Length: 948
• Species: Caenorhabditis elegans
• Alignment Length: 1028
• Identity: 232/1028 - (22%)
• Similarity: 390/1028 - (37%)
• Gaps: 290/1028 - (28%)

  Fly   124 IATNGEPFPWLE-KMLPTSVRPLRYMVTIHPNLTTLDVKGQVTIDLHVEKETNFIVLHIQDLNVT 187
            :|..|.|...:: :.|||...|..|.|.:.|.|......|..|||:.:::.|:.:.:|.|.|.:.
 Worm    65 MAACGNPSAAVKFERLPTFAEPTHYNVRLSPCLNQFSFDGHATIDVTIKEATDVLKVHAQSLLIQ 129

  Fly   188 EKAIVT-PGPKGYALKI-------VKVLEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPE 244
            ..:::| ||....:|:.       :..::.|...|           .....|:.::..:||.:..
 Worm   130 SVSLITQPGDASKSLETSYDDKLNILTIKLPTTMQ-----------PQKVQLDFKFVGELNDKMR 183

  Fly   245 GFYVDQYESSNGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTE 309
            |||..||:..||.|:.||:|.|....||.||||||||..:|.|.:::..:.....|||..|
 Worm   184 GFYRSQYKDKNGTEKFLASTQFESTYARYAFPCFDEPIYKATFDVTLEVENHLTALSNMNV---- 244

  Fly   310 DVGFYMGTGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLN 374
                          ..|||  .||                                 ||:.|
 Worm   245 --------------ISETP--TAD---------------------------------GKRKA--- 257

  Fly   375 NYTQLKGKNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGS 439
                          :|..|       :|:.:..:|      |:.|        ..|..:|..|.|
 Worm   258 --------------VTFAT-------SPKMSSYLV------AFAV--------GELEYISAQTKS 287

  Fly   440 SIKRAPSYTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGL 504
            .::.. .||....::   :..:.|..|...:::...|.||.|||.|.|.:|:|......:.:.||
 Worm   288 GVEMR-VYTVPGKKE---QGQYSLDLSVKCIDWYNEWFDIKYPLPKCDLIAIPDFSMGAMENWGL 348

  Fly   505 VTLK-TSFLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEG---LIQYLGIHA 565
            ||.: .:.|.||...::.|....||.:|..:...:||.:.:.|...|:||.||   .::|:.:.|
 Worm   349 VTYREIALLVDPGVTSTRQKSRVALVVAHELAHLWFGNLVTMKWWTDLWLKEGFASFMEYMFVGA 413

  Fly   566 LAPLQETWPLREMYLLKMATAA-LDIDAIQGWDSIMNGTSH------DGNNE--EFF----VQKT 617
            ..|..:.|    ::.|....|: :.:||::        .||      |..||  |.:    ..|:
 Worm   414 NCPEFKIW----LHFLNDELASGMGLDALR--------NSHPIEVEIDNPNELDEIYDSITYAKS 466

  Fly   618 AAIFSMLHTAIGEDRFRGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPGFP 682
            .::..||...:.|..|:..|..:||..::..|...|||| ...:|:| :|:.::|:.||.|.|||
 Worm   467 NSVNRMLCYYLSEPVFQKGLRLYLKRFQYSNAVTQDLWT-ALSEASG-QNVNELMSGWTQQMGFP 529

  Fly   683 LLTVTKM--GNS--ISISQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKV 743
            :|.|::.  ||:  :::.||.|       |.|...|..|
 Worm   530 VLKVSQRQDGNNRILTVEQRRF-------ISDGGEDPKN-------------------------- 561

  Fly   744 APHMKWIFPVTYV--TDINNVSETLWMQNVDVTFNVPENV---KWIKVNAIQNGYYRVVYNDDNW 803
               .:|..|:|..  :..::|.....::.....|.: |.|   :|:|:|:...|:|||.|:|:..
 Worm   562 ---SQWQVPITVAVGSSPSDVKARFLLKEKQQEFTI-EGVAPGEWVKLNSGTTGFYRVEYSDEML 622

  Fly   804 ASLIEELAANPNRFTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEK 868
            .:::.::|:  .|....||.|:::|...|.:...:.....:.:......|..|          ..
 Worm   623 TAMLPDIAS--RRMPVLDRFGLINDLSALLNTGRVSIAQFVQVAASSAKEDEY----------VV 675

  Fly   869 WRRI----LKYSECFLMLSE---------FIKMKISTVMEKVGWSDDG--DVATRLLRPEVLLAS 918
            |..|    .|...|...:||         .:||...|..| :|:::..  |....:||..|....
 Worm   676 WGAIDEGMSKLLACAREMSEDTLKSAKQLVVKMFEQTGAE-LGFAEQAGEDSQKMMLRSLVQARL 739

  Fly   919 VLWEDIDSITKAKNMLNQYLYYNGTAIPPNLREVV------YTGSILSGEYIYWQHCWERFVNLQ 977
            .......:|.|...|.|.:| ..||.|.|::|...      |.|          :..:::.:||:
 Worm   740 ARAGHQPTIDKFTQMFNDFL-EKGTPIHPDIRLATFGVVARYGG----------KEGFDKLMNLR 793

  Fly   978 RTSETF--VERMQLLRALGRTKDAWLQNRLLSHVTMLPTEEVVQVLKAIAGTPTGGAMACRFLQA 1040
            .|: ||  :||                                |.:.|::.||....:|..|...
 Worm   794 ETT-TFQEIER--------------------------------QTMVAMSQTPEESLLAQLFEYG 825

  Fly  1041 KWFELEK---------RLGPGTISFAKVISAITQYGATKFDYDELKSLVHRFG 1084
              ||..|         .||.|.....:      || |.|:..:.:|..:.::|
 Worm   826 --FEKNKVRPQDQLYLFLGTGATHMGQ------QY-AWKYFCEHIKEFLDKYG 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	132/556 (24%)
		ERAP1_C	783..1078	CDD:463368	68/326 (21%)
pam-1	NP_001023210.1	M1_APN-Q_like	87..524	CDD:341064	132/556 (24%)
		ERAP1_C	602..927	CDD:463368	70/334 (21%)