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Protein Alignment fzo and MFN2

DIOPT Version :10

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_055689.1	Gene:	MFN2 / 9927	HGNCID:	16877	Length:	757	Species:	Homo sapiens

Alignment Length:	757	Identity:	259/757 - (34%)
Similarity:	401/757 - (52%)	Gaps:	84/757 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSSRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETV-------LLKDRQMLEHLCAFSSRVEAI 78
            ::|.|..||.||.::..|:..|..|:....|.||:|.       :..:.|:|: :..:.|:|..|
Human    25 NASPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEEQVLD-VKGYLSKVRGI 88

  Fly    79 AKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQED 143
            ::||:|..||||||||||||||.||||:|.:|:|||.:||||:||.:|:....:|. .:..|..:
Human    89 SEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVEGTDGHEA-FLLTEGSE 152

  Fly   144 EHMELSALSQLASA-HSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYC 207
            |......::|||.| |....|...:|:.|....::|.:|..|:||||:||:|||.:||..:|.:|
Human   153 EKRSAKTVNQLAHALHQDKQLHAGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFC 217

  Fly   208 MDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERC 272
            :|||||:||.|:|||:.:.|:.||..|:.:|||||:|||||||| ||:.|||..::|:.||||||
Human   218 LDADVFVLVANSESTLMQTEKHFFHKVSERLSRPNIFILNNRWD-ASASEPEYMEEVRRQHMERC 281

  Fly   273 VNLLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITNPSGQT----------QQRYQEFLRFE 327
            .:.|||||||...:| |.:||:.|||.|.|   |.:|....|..          |.|..||..||
Human   282 TSFLVDELGVVDRSQ-AGDRIFFVSAKEVL---NARIQKAQGMPEGGGALAEGFQVRMFEFQNFE 342

  Fly   328 NDFSNCLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSR----LIDENKERRANLNAEIE 388
            ..|..|::.||:||||..|.:.|::|...::  ||...:...:|    ..:|.:|.|.:....|:
Human   343 RRFEECISQSAVKTKFEQHTVRAKQIAEAVR--LIMDSLHMAAREQQVYCEEMREERQDRLKFID 405

  Fly   389 DWLILMQEDREALQYCFEELTEMTQRVGRCVLNDQIKTLIPSSVL--SFSQPFHPEFPAQIGQYQ 451
            ..|.|:.:|   .:...:::||..:|.....:.::|:.|   |||  .:...|||. |..:..|:
Human   406 KQLELLAQD---YKLRIKQITEEVERQVSTAMAEEIRRL---SVLVDDYQMDFHPS-PVVLKVYK 463

  Fly   452 RSLCAHLD----KLLEDRVLQCLSIPL---QRKILDIEKEIGLPIAENS---------CDWQLIY 500
            ..|..|::    :.:.||....::..|   |:.::|..|.: ||::..|         | :.|.|
Human   464 NELHRHIEEGLGRNMSDRCSTAITNSLQTMQQDMIDGLKPL-LPVSVRSQIDMLVPRQC-FSLNY 526

  Fly   501 GLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLHASPFRIQKLQNGHK----------KCSP 555
            .|:|....:|||.|:.|.||||:|.|.:|..|       |...::...|:.          ..:|
Human   527 DLNCDKLCADFQEDIEFHFSLGWTMLVNRFLG-------PKNSRRALMGYNDQVQRPIPLTPANP 584

  Fly   556 -LPPLVNGNHWQ------MLESL--VKSKGSLGTVLLSAMAIRSFNWPIVLILGGLVGSFYIYEY 611
             :|||..|:..|      |:..|  :.|:.|:|.:::..:..::..|.::.:..||.|..|:||.
Human   585 SMPPLPQGSLTQEEFMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYER 649

  Fly   612 AAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLATVRNCWEAQSNETLNDLNVRT 676
            ..|||.|:||:||.|:.....::|:..:..|.|....|::|.|:........|.:.|..:|....
Human   650 LTWTTKAKERAFKRQFVEHASEKLQLVISYTGSNCSHQVQQELSGTFAHLCQQVDVTRENLEQEI 714

  Fly   677 AELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYLTKS 718
            |.:.|:|:.::.||...|..|:|...|.|.|..|...||..|
Human   715 AAMNKKIEVLDSLQSKAKLLRNKAGWLDSELNMFTHQYLQPS 756

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.