DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and MGM1

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_014854.2	Gene:	MGM1 / 854386	SGDID:	S000005737	Length:	881	Species:	Saccharomyces cerevisiae

Alignment Length:	787	Identity:	145/787 - (18%)
Similarity:	275/787 - (34%)	Gaps:	230/787 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DSG---ESTSSVSSFISSSS-----SSRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETVLLKD 61
            |.|   :.|...::.|:::|     |.|..:..|...|..|...|.::.:..    .::.:|...
Yeast   128 DGGHGNDGTVPTATLIAATSLDDDESKRQGDPKDDDDEDDDDEDDENDSVDT----TQDEMLNLT 188

  Fly    62 RQMLEHLCAFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQV 126
            :||:| :....::|::.:..|:..  .:...|..|:|||:|:.:::..:.||......|....::
Yeast   189 KQMIE-IRTILNKVDSSSAHLTLP--SIVVIGSQSSGKSSVLESIVGREFLPKGSNMVTRRPIEL 250

  Fly   127 ----QANGSNETE--------HVKVEQEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCS 179
                ..|.:|.|.        ::|..:|.:.| |..|:.........:.:|   :|:.:..:|..
Yeast   251 TLVNTPNSNNVTADFPSMRLYNIKDFKEVKRM-LMELNMAVPTSEAVSEEP---IQLTIKSSRVP 311

  Fly   180 ILDYDVVLMDTPG----------VDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDV 234
                |:.|:|.||          :::..::.|..:.| :.|...||.::| :.|........|
Yeast   312 ----DLSLVDLPGYIQVEAADQPIELKTKIRDLCEKY-LTAPNIILAISA-ADVDLANSSALK-- 368

  Fly   235 ASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYSTAQEAWERIYHV--- 296
            |||.:.|..........|...::||..:.:.:   .:...|.:..:||.:....:..| .|:
Yeast   369 ASKAADPKGLRTIGVITKLDLVDPEKARSILN---NKKYPLSMGYVGVITKTPSSINR-KHLGLF 429

  Fly   297 -----SALEALHIRNGQITNPSGQ---------TQQRYQEFLRFEND--FSNCLAVSALKTKFGP 345
                 |:|..: ...||....||:         ...::::....||.  |:|| .||..|.:
Yeast   430 GEAPSSSLSGI-FSKGQHGQSSGEENTNGLKQIVSHQFEKAYFKENKKYFTNC-QVSTKKLR--- 489

  Fly   346 HLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTE 410
                                 ||:.::::      .:::..:|....|:|::.:...|.|
Yeast   490 ---------------------EKLIKILE------ISMSNALEPTSTLIQQELDDTSYLF----- 522

  Fly   411 MTQRVGRCVLNDQIKTLIPSSVL------------SFSQPFHPEFPAQIGQYQRSLCAHLDKLLE 463
                  :...||  :.|.|.|.|            .|.:.||                      .
Yeast   523 ------KVEFND--RHLTPKSYLLNNIDVLKLGIKEFQEKFH----------------------R 557

  Fly   464 DRVLQCLSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWH 528
            :.:...|...|.:|:||:       :|...  |:.....|..|...:...|:.:         ||
Yeast   558 NELKSILRAELDQKVLDV-------LATRY--WKDDNLQDLSSSKLESDTDMLY---------WH 604

  Fly   529 RLEGNLPLHASPF------RIQKLQNGHKKCSPLPPLVNG----NHWQMLESLVKSKGSLGTVLL 583
            :   .|.|.:|..      |:..:...:.....|..::..    || ::::.||.:...  .||.
Yeast   605 K---KLELASSGLTKMGIGRLSTMLTTNAILKELDNILESTQLKNH-ELIKDLVSNTAI--NVLN 663

  Fly   584 SAM---------AIRSFNWPIVLILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLR--- 636
            |..         .|:.|.:.|.|            |...|:.|.|..      ..|:::.||
Yeast   664 SKYYSTADQVENCIKPFKYEIDL------------EERDWSLARQHS------INLIKEELRQCN 710

  Fly   637 ---SDVQQTVSGFELQLRQHLATVRNCWEAQSN---ETLND---LNVRTAELTKQIQSMEVLQLS 692
               ..::..|..      :.||.|....|.:||   |||..   |..|.:|.....:..:||...
Yeast   711 SRYQAIKNAVGS------KKLANVMGYLENESNLQKETLGMSKLLLERGSEAIFLDKRCKVLSFR 769

  Fly   693 LKKFRDK 699
            ||..::|
Yeast   770 LKMLKNK 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	55/287 (19%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	33/149 (22%)
MGM1	NP_014854.2	CrfC	93..826	CDD:223771	145/787 (18%)
MGM1	NP_014854.2	DLP_1	208..468	CDD:206738	52/278 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900