Protein Alignment fzo and VPS1

DIOPT Version :9

• Sequence 1: NP_732840.1
• Gene: fzo / 42745
• FlyBaseID: FBgn0011596
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_012926.1
• Gene: VPS1 / 853870
• SGDID: S000001709
• Length: 704
• Species: Saccharomyces cerevisiae
• Alignment Length: 829
• Identity: 153/829 - (18%)
• Similarity: 268/829 - (32%)
• Gaps: 313/829 - (37%)

  Fly    64 MLEHLCAFSSRVEAIAKVLSR------DRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTT-- 120
            |.|||.:..::::.....|..      |..::...|..|:|||:|:..::....||...|..|
Yeast     1 MDEHLISTINKLQDALAPLGGGSQSPIDLPQITVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRR 65

  Fly   121 SCFCQVQANGSNETEHVKVEQ------------EDEHMELSALSQLAS------------AHSP- 160
            ....|:......::||.||.|            :|:..:.|...|...            .|.|
Yeast    66 PLVLQLINRRPKKSEHAKVNQTANELIDLNINDDDKKKDESGKHQNEGQSEDNKEEWGEFLHLPG 130

  Fly   161 ---------------------GALKPSTLLQVNMAKNRCSILDYDVVLMDTPGV----------D 194
                                 ||....:.:.:|:......:|  .:.|:|.||:          |
Yeast   131 KKFYNFDEIRKEIVKETDKVTGANSGISSVPINLRIYSPHVL--TLTLVDLPGLTKVPVGDQPPD 193

  Fly   195 VTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVAS----KLSRPNLFILNNRWDKASS 255
            :..|:.|.|..|....:..||.:||.:|          |:|:    ||:|              .
Yeast   194 IERQIKDMLLKYISKPNAIILSVNAANT----------DLANSDGLKLAR--------------E 234

  Fly   256 LEPEMEQKVKDQHMERCVNLLVDELGVYSTA--QEAWERIYHVSALEALHIRNGQITNP---SGQ 315
            ::||..:.:                ||.:..  .:....:..:.|...:.:|.|.|  |   .||
Yeast   235 VDPEGTRTI----------------GVLTKVDLMDQGTDVIDILAGRVIPLRYGYI--PVINRGQ 281

  Fly   316 TQQRYQEFLR--FEND---FSNCLAVSALKTKFG-PHLLSAQK----ILNQLKSTLICPFIE-KV 369
            ....:::.:|  .||:   |.|..:.|:.....| |:|  |:|    :|:.::.||  |.|: |:
Yeast   282 KDIEHKKTIREALENERKFFENHPSYSSKAHYCGTPYL--AKKLNSILLHHIRQTL--PEIKAKI 342

  Fly   370 SRLIDENKERRANLNAEIEDWL-----------------ILMQEDRE----------ALQYCFEE 407
            ...:.:.:....||..|..|..                 ||..|.:|          .:.|.|.|
Yeast   343 EATLKKYQNELINLGPETMDSASSVVLSMITDFSNEYAGILDGEAKELSSQELSGGARISYVFHE 407

  Fly   408 LTEMTQRVGRCVLN--DQIK--------------------------TLIPSSVLSF--------- 435
                |.:.|...|:  ||||                          .|:...:..|
Yeast   408 ----TFKNGVDSLDPFDQIKDSDIRTIMYNSSGSAPSLFVGTEAFEVLVKQQIRRFEEPSLRLVT 468

  Fly   436 --------------SQPFHPEFPAQIGQYQRSLCAHLDKLLEDRVLQCL---SIPLQRKILDIEK 483
                          |||.:..:||            |.:.:.::.:|.|   :||....::||.|
Yeast   469 LVFDELVRMLKQIISQPKYSRYPA------------LREAISNQFIQFLKDATIPTNEFVVDIIK 521

  Fly   484 EIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNL-------PLHASPF 541
                  ||             |:|::...|||              |:|:.       .||....
Yeast   522 ------AE-------------QTYINTAHPDL--------------LKGSQAMVMVEEKLHPRQV 553

  Fly   542 RIQKLQNGHKKCSPLPPLVNGNHWQMLESLVKS---KGSLGTVLLSAMAIRSFNWPIVLILGGLV 603
            .:..     |...|||...:.:...::|.  ||   .|...|.....:|......|::...|.:
Yeast   554 AVDP-----KTGKPLPTQPSSSKAPVMEE--KSGFFGGFFSTKNKKKLAALESPPPVLKATGQM- 610

  Fly   604 GSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGF---ELQLRQHLAT--------V 657
                          .:..:.:::..:||.....|.|::|::..   .|.|:..:.:        :
Yeast   611 --------------TERETMETEVIKLLISSYFSIVKRTIADIIPKALMLKLIVKSKTDIQKVLL 661

  Fly   658 RNCWEAQSNETLNDLNVRTAELTKQIQSM-EVLQLSLKKFRDKGQLLAS 705
            ...:..|..|.|...|..|.:..|:.:.| |:|       |:..|:::|
Yeast   662 EKLYGKQDIEELTKENDITIQRRKECKKMVEIL-------RNASQIVSS 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	60/318 (19%)
		Fzo_mitofusin	572..716	CDD:282633	26/149 (17%)
VPS1	NP_012926.1	DLP_1	27..336	CDD:206738	70/356 (20%)
		Dynamin_M	258..541	CDD:395818	66/337 (20%)
		GED	616..704	CDD:396682	19/95 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900