DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and FZO1

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_009738.1	Gene:	FZO1 / 852477	SGDID:	S000000383	Length:	855	Species:	Saccharomyces cerevisiae

Alignment Length:	781	Identity:	159/781 - (20%)
Similarity:	285/781 - (36%)	Gaps:	251/781 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 HLCAFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQV----Q 127
            ||.|...||:.::.       ||...|..:.||||:.|:||.:::||......|:.|.::    :
Yeast   175 HLNALKKRVDDVSS-------KVFITGDVNTGKSALCNSLLKQRLLPEDQLPCTNVFSEILEARE 232

  Fly   128 ANGSNETEHVKVE--------------QEDEHMELSALSQLASAHSPGALKPS----TLLQVNMA 174
            .:|..|...:.:.              |..:..|:..|.:|..      |.|.    .||::.:.
Yeast   233 NDGIEEVHAIPLNIAPTLKEAIDMYSIQNPKTYEIHTLKELPD------LVPQNGKYALLKIYIK 291

  Fly   175 KNR----CSIL---DYDVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFK 232
            .::    .|:|   ..|:.|:|:||:::.:.....:.|...:.|:.|.|:|||:.::...::|.
Yeast   292 DDKRPASTSLLRNGTVDISLIDSPGLNMDSLQTAEVMSRQEEIDLVIFVVNAENQLTLSAKEFI- 355

  Fly   233 DVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYS--TAQEAWERIYH 295
            .:||: .:..:|.:..::|           |::|:  :||..|::.::...|  |.:.|.:.::.
Yeast   356 SLASR-EKKLMFFVVKKFD-----------KIRDK--QRCKELILKQIRDLSPETYKRAADFVHF 406

  Fly   296 VS--ALEALHIRNGQITNPSGQTQQRYQEFLRFEND-----FSNCLAVSALKTKFGPHLLSAQKI 353
            ||  ..|..|..|.......|..:.....:...:.|     ..:.|....||.:....||.|:..
Yeast   407 VSKNGDELPHYHNENDNEDHGDRKPDDDPYSSSDPDPDFDSLEDSLRNFVLKKRSLSKLLPAKTY 471

  Fly   354 LNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQRVGRC 418
            |::|.|.:|  .|.|            :|:.                 .|..||:.
Yeast   472 LSKLLSDII--MISK------------SNMK-----------------MYSEEEIK--------- 496

  Fly   419 VLNDQIKTLIPSSVLSFSQPFHPEFPAQIGQYQRSLCAHL----DKLLE-----------DRVLQ 468
             :|:|::||.| .:||                .|:.|..|    |::.|           :.:|.
Yeast   497 -INEQLETLRP-EILS----------------ARAKCNDLTTSVDQMAEQTITMTYNNTKEALLN 543

  Fly   469 CLSIPLQR--------KILD------------IEKEIGLP--IAENSCDW--QLIYGLDCQSYMS 509
            .|.:||..        :|.|            |::.||..  .|:...|.  :.||.:.......
Yeast   544 ALDVPLHEYPKYQGLGQIYDFIFSTEAFIANQIDESIGSSELFAKQKTDLLVKKIYEIGKNELGD 608

  Fly   510 DFQPDLRFRFSLGFTALWH----RLEGNL---PLHASPFR--IQKLQNGHKKCSPLP-------- 557
            ||..:..||..|.|....|    ||:.:|   .|.|..::  :..|.......:|||
Yeast   609 DFMCERVFRSELMFRKRKHLIGKRLKVSLSITDLFAPTWKGFLSYLSWQKPVTAPLPDIEGQTNE 673

  Fly   558 --------------PLVNGNHWQMLESLVKSK---------GS---LGTVLLSAMAIRSFNWPI- 595
                          ||.  .:|.....|..||         ||   :|.::|:.:.:.|  |..
Yeast   674 GQIGLMKYLGLKNYPLT--QYWSRPSLLFTSKIPTLTLYFLGSTKVVGNIILNGIKLSS--WSSL 734

  Fly   596 ------VLILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQ--RLRSDVQQTVSGFELQLRQ 652
                  |:::|.|:|..|:...   ...|...:...:|.|.||:  .:..:.|:|
Yeast   735 KKLSVPVIVVGSLLGLTYLIHD---LPRALPMNLSIKYKRKLQELDYIHLNAQRT---------- 786

  Fly   653 HLATVRNCWEAQSNETLNDLNVRTAELTKQIQSMEVL----QLSLKKFRDKGQLLASRLGDFQET 713
                        |||..:.|.|.|.|:   ::|.|::    |::.|:..:|.:.....:..||..
Yeast   787 ------------SNEVRDVLRVPTREI---LRSCEIIMDKKQITKKELENKKESNLLSIKFFQSL 836

  Fly   714 Y 714
            |
Yeast   837 Y 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	58/284 (20%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	35/168 (21%)
FZO1	NP_009738.1	CrfC	128..841	CDD:223771	159/781 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344493
Domainoid	1	1.000	41	1.000	Domainoid score	I3231
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10465
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930