DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and DNM1

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_013100.1	Gene:	DNM1 / 850686	SGDID:	S000003924	Length:	757	Species:	Saccharomyces cerevisiae

Alignment Length:	766	Identity:	129/766 - (16%)
Similarity:	237/766 - (30%)	Gaps:	292/766 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LSEFVDAKTELQDIYHDLSNYLSNFLTILEETVLLKDRQMLEHLCAFSSRVEAIAKVLSRDRMKV 89
            |.:.:....:|||:.:|                               |.::.:      |...:
Yeast     4 LEDLIPTVNKLQDVMYD-------------------------------SGIDTL------DLPIL 31

  Fly    90 AFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQEDE----HMELSA 150
            |..|..|:|||:::..|:....||...|..|.....:|.|..:....: :|::|.    |.|::.
Yeast    32 AVVGSQSSGKSSILETLVGRDFLPRGTGIVTRRPLVLQLNNISPNSPL-IEEDDNSVNPHDEVTK 95

  Fly   151 LSQLASA---------------------HSPGAL----------------------KPSTLLQVN 172
            :|...:.                     |.||..                      |..:.:.:|
Yeast    96 ISGFEAGTKPLEYRGKERNHADEWGEFLHIPGKRFYDFDDIKREIENETARIAGKDKGISKIPIN 160

  Fly   173 MAKNRCSILDYDVVLMDTPGV----------DVTAQLDDCLDSYCMDADVFILVLNAESTVSRVE 227
            :......:|  ::.|:|.||:          |:..|:.:.:..|....:..||.
Yeast   161 LKVFSPHVL--NLTLVDLPGITKVPIGEQPPDIEKQIKNLILDYIATPNCLILA----------- 212

  Fly   228 RQFFKDVASKLSRPNLFILNNRWDK-ASSLEPEMEQKVKDQHMERCVNLLVDELGVYSTAQEAWE 291
                      :|..|:.::|:...| |..::|:.::.:.          ::.:|.:..
Yeast   213 ----------VSPANVDLVNSESLKLAREVDPQGKRTIG----------VITKLDLMD------- 250

  Fly   292 RIYHVSALEALHIRNGQ----------ITNPSGQTQQ---RYQEFLRFEND-FSNCLAVSALKTK 342
                 |...||.|.:|:          :.|.|.|..|   ..:|.|..|.| |........:.||
Yeast   251 -----SGTNALDILSGKMYPLKLGFVGVVNRSQQDIQLNKTVEESLDKEEDYFRKHPVYRTISTK 310

  Fly   343 FGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEE 407
            .|...|:  |:|||   ||:       |.:.|:..:.:..||.      ::.|.::|..:|....
Yeast   311 CGTRYLA--KLLNQ---TLL-------SHIRDKLPDIKTKLNT------LISQTEQELARYGGVG 357

  Fly   408 LTEMTQRVGRCVLNDQIKTLIPSSVLSFSQPFHPEFPAQIGQYQ-----RSLCAHLDKLLEDRVL 467
            .|....|.              |.||.....|...|.:.|....     :.||...      |:.
Yeast   358 ATTNESRA--------------SLVLQLMNKFSTNFISSIDGTSSDINTKELCGGA------RIY 402

  Fly   468 QCLSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMSD--------FQPDLRFRFSLGFT 524
            ...:......:..|:....|.:            ||.::.:.:        |.|:|.|
Yeast   403 YIYNNVFGNSLKSIDPTSNLSV------------LDVRTAIRNSTGPRPTLFVPELAF------- 448

  Fly   525 ALWHRLEGNLPLHASPFRIQKLQNGHKKCSPLPPLVNGNHWQMLESLVKSKGSLGTVLLSAMAIR 589
                      .|...| :|:.|....::|..|          :.|.|:|.....|:..|
Yeast   449 ----------DLLVKP-QIKLLLEPSQRCVEL----------VYEELMKICHKCGSAEL------ 486

  Fly   590 SFNWPIVLILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHL 654
                                        |:....||....::.:.||..:|.|.|..|..:..|.
Yeast   487 ----------------------------ARYPKLKSMLIEVISELLRERLQPTRSYVESLIDIHR 523

  Fly   655 ATVR----NCWEAQSNETLNDLNVRTAELTKQIQSMEVLQLSLKKFRDKGQ 701
            |.:.    |...|  .|.::|:     ..|::.::.|:|:..|.: ::.||
Yeast   524 AYINTNHPNFLSA--TEAMDDI-----MKTRRKRNQELLKSKLSQ-QENGQ 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	54/318 (17%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	24/134 (18%)
DNM1	NP_013100.1	DLP_1	26..333	CDD:206738	67/370 (18%)
		Dynamin_M	255..540	CDD:395818	74/398 (19%)
		GED	665..756	CDD:128597
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900