DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and FZL

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_171815.3	Gene:	FZL / 839566	AraportID:	AT1G03160	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	775	Identity:	149/775 - (19%)
Similarity:	272/775 - (35%)	Gaps:	211/775 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SSVSSFISSSSSSRLSEFVDAKTELQDIY----HDLSNY--------LSNFLTI---------LE 54
            |.||.|:.|....|.|..|..:..|...|    |:..|.        .:.|:.:         :|
plant   251 SGVSGFVISLKDLRSSRDVALRQSLDGAYVVNNHETQNMNELPEKKNSAGFIKLEDKQKLIVEME 315

  Fly    55 ETVLLKDRQMLEHLCAFSSRVEAIAKVLSR--DRMKVAFFGRTSNGKSAVINALLHEKILPSAMG 117
            ::||.:..:::.........|..:...:||  :...:...|..::|||.||||||.::.|...:.
plant   316 KSVLRETIEIIHKAAPLMEEVSLLIDAVSRIDEPFLMVIVGEFNSGKSTVINALLGKRYLKEGVV 380

  Fly   118 HTTS-----CFCQVQANGSNETEHVKVEQEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKNR 177
            .||:     |:..::   |.|.:..:...:.:::               ...|:.:|:
plant   381 PTTNEITFLCYSDLE---SEEQQRCQTHPDGQYV---------------CYLPAPILK------- 420

  Fly   178 CSILDYDVVLMDTPGVDVTAQLDDCL-DSYCMDADVFILVLNAESTVSRVERQFFKDVASKLSRP 241
                  |:.::||||.:|..|....| :.:...||:.:.||:|:..::..|..|.: ...:..:.
plant   421 ------DINIVDTPGTNVILQRQQRLTEEFVPRADLLVFVLSADRPLTESEVAFLR-YTQQWKKK 478

  Fly   242 NLFILNNR--WDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYSTAQEAWERIYHVSALEALHI 304
            .:||||..  :..|..|| |....||    |....||..|..:          :|.|||..||..
plant   479 FVFILNKSDIYRDARELE-EAISFVK----ENTRKLLNTENVI----------LYPVSARSALEA 528

  Fly   305 R----------NGQITNPSG----QTQQRYQEFLRFENDFSNCLAVSALKTKFGPHLLSAQKILN 355
            :          :.:|.:|..    |:....::||....|.|....:..::.|....:..|:::|:
plant   529 KLSTASLVGRDDLEIADPGSNWRVQSFNELEKFLYSFLDSSTATGMERIRLKLETPMAIAERLLS 593

  Fly   356 QLKSTL--IC----PFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQR 414
            .:::.:  .|    ..:....::|...||....:..|...|      .|:||........::...
plant   594 SVEALVRQDCLAAREDLASADKIISRTKEYALKMEYESISW------RRQALSLIDNARLQVVDL 652

  Fly   415 VGRCVLNDQIKTLIPSSV-LSFSQPFHPEFPAQIGQYQRSLCAHLDKLLEDRVLQCLSIPLQRKI 478
            :|        .||..||: |:.|..|..|..|.:....:
plant   653 IG--------TTLRLSSLDLAISYVFKGEKSASVAATSK-------------------------- 683

  Fly   479 LDIEKEIGLPIAENS-------CDWQLIY-----GLDCQSYMSDFQPDLRFRFSLGFTALWHRLE 531
              ::.||..|...|:       .:|....     .|..:|:.:.:...:..:..||....
plant   684 --VQGEILAPALTNAKELLGKYAEWLQSNTAREGSLSLKSFENKWPTYVNSKTQLGIDTY----- 741

  Fly   532 GNLPLHASPFRIQKLQNGHKKCSPLPPLVNGNHWQMLESLVK-----SKGSLGTVLLSAMAIRSF 591
             :|........::.:||          |..|...:.||..::     :.|.||...|||..:.|.
plant   742 -DLLQKTDKVSLKTIQN----------LSAGTTSKRLEQDIREVFFVTVGGLGAAGLSASLLTSV 795

  Fly   592 ---NWPIVLILGGLVGSFYI----YEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQ 649
               ....:|.||......|:    :.|.......:    .::.|..|.|:|...:|:.:|
plant   796 LPTTLEDLLALGLCSAGGYVAIANFPYRRQAIIGK----VNKVADALAQQLEDAMQKDLS----- 851

  Fly   650 LRQHLATVRNCWEAQSNETLNDLNV------RTAELTKQIQSMEVLQLSLKKFRDKGQLL 703
                        :|.|| .:|.:|:      ..|:|  ::..:..:|..|...|.|.|||
plant   852 ------------DATSN-LVNFVNIVAKPYREEAQL--RLDRLLGIQKELSDIRSKLQLL 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	60/268 (22%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	32/150 (21%)
FZL	NP_171815.3	TIM	96..>212	CDD:389746
FZL	NP_171815.3	DLP_2	350..566	CDD:206739	58/262 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	42	1.000	Domainoid score	I4784
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900