DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fzo and Mfn1

DIOPT Version :9

Sequence 1:NP_732840.1 Gene:fzo / 42745 FlyBaseID:FBgn0011596 Length:718 Species:Drosophila melanogaster
Sequence 2:NP_077162.2 Gene:Mfn1 / 67414 MGIID:1914664 Length:741 Species:Mus musculus


Alignment Length:760 Identity:259/760 - (34%)
Similarity:403/760 - (53%) Gaps:92/760 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 SRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETV-------LLKDRQMLEHLCAFSSRVEAIAK 80
            |.|..||.||..:..|:..|..:::.....:|.|.       :..:..::| :..:.:::..|.:
Mouse     6 SPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIASEDDLVE-IQGYRNKLAVIGE 69

  Fly    81 VLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQEDEH 145
            ||||..||||||||||:|||:||||:|.:|:|||.:||||:||..|:....::. ::..|..||.
Mouse    70 VLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKA-YLMTEGSDEK 133

  Fly   146 MELSALSQLASA-HSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMD 209
            ..:..::|||.| |....||...|:.|...|.:|::|..|:||:|:||.|||.:||..:|.:|:|
Mouse   134 KSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCLD 198

  Fly   210 ADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVN 274
            ||||:||.|:|||:...|:.||..|..:||:||:|||||||| ||:.|||..:.|:.||||||::
Mouse   199 ADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD-ASASEPEYMEDVRRQHMERCLH 262

  Fly   275 LLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITN-PSG------QTQQRYQEFLRFENDFSN 332
            .||:||.|.|.: ||..||:.|||.|.|:.|..:... |.|      ..|.|.|||..||..|..
Mouse   263 FLVEELKVVSPS-EARNRIFFVSAKEVLNSRKHKAQGMPEGGGALAEGFQARLQEFQNFEQTFEE 326

  Fly   333 CLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNA--EIEDWLILMQ 395
            |::.||:||||..|.:.|::||:.:|:.|....:....:.:...:||...::.  .|.:.:.|:.
Mouse   327 CISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLT 391

  Fly   396 EDREALQYCFEELTEMTQRVGR---CVLNDQIKTLIPSSVL--SFSQPFHPEFPAQIGQYQRSLC 455
            .|.:      :::.|:|:.|..   |.:.|:|..|   |||  .|...|||. |:.:..|:..|.
Mouse   392 LDVK------KKIKEVTEEVANKVSCAMTDEICRL---SVLVDEFCSEFHPT-PSVLKVYKSELN 446

  Fly   456 AHLD----KLLEDR--------VLQCLSIPLQRKILDIEKEIGLPIA-ENS------C-DWQLIY 500
            .|::    :.|.||        :||.     |::|::..|.: ||.. :|.      | .:.|.|
Mouse   447 KHIEDGMGRNLADRCTNEVNASILQS-----QQEIIENLKPL-LPAGIQNKLHTLIPCKKFDLSY 505

  Fly   501 GLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGN-------LPLHASPFRIQK--LQNGHKKCSPL 556
            .|:|....||||.|:.||||||:::|.||..|:       |.|....|::.:  ........:|.
Mouse   506 DLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPA 570

  Fly   557 PP-----------LVNGNHWQMLESLVKSKGSLGTVLLSAMAIRSFNWPIVLILGGLVGSFYIYE 610
            .|           |:.|     |.||. |:.|:|.:::..:..::..|.::.:...:.|:.|:||
Mouse   571 APDNAAQEELMITLITG-----LASLT-SRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYE 629

  Fly   611 YAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLAT--VRNCWEAQSNETLNDLN 673
            ...|||.|:||:||.|:.....::|:..|..|.:....|::|.:||  .|.|  .|.:.|...|.
Mouse   630 RLTWTTRAKERAFKQQFVNYATEKLQMIVSFTSANCSHQVQQEMATTFARLC--QQVDVTQKHLE 692

  Fly   674 VRTAELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYLTKS 718
            ...|.|:|:|..:|.:|.:.|..|:|...|.|.|.:|.:.:|..|
Mouse   693 EEIARLSKEIDQLEKIQNNSKLLRNKAVQLESELENFSKQFLHPS 737

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
fzoNP_732840.1 DLP_2 87..334 CDD:206739 122/254 (48%)
Fzo_mitofusin 572..716 CDD:282633 42/145 (29%)
Mfn1NP_077162.2 Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions. /evidence=ECO:0000250|UniProtKB:Q8IWA4 9..73 12/64 (19%)
DLP_2 76..328 CDD:206739 122/254 (48%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 82..89 5/6 (83%)