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Protein Alignment fzo and Mfn2

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_570964.4	Gene:	Mfn2 / 64476	RGDID:	628843	Length:	757	Species:	Rattus norvegicus

Alignment Length:	758	Identity:	261/758 - (34%)
Similarity:	403/758 - (53%)	Gaps:	86/758 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSSRLSEFVDAKTELQDIYHDLSNYLSNFLTILEET-------VLLKDRQMLEHLCAFSSRVEAI 78
            ::|.|..||.||.::..|:..|..|:......||:|       .:..:.|:|: :..:.|:|..|
  Rat    25 NASPLKHFVTAKKKINGIFEQLGAYIQESAGFLEDTHRNTELDPVTTEEQVLD-VKGYLSKVRGI 88

  Fly    79 AKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQED 143
            ::||:|..||||||||||||||.||||:|.:|:|||.:||||:||.:|.....:|. .:..|..:
  Rat    89 SEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHEA-FLLTEGSE 152

  Fly   144 EHMELSALSQLASA-HSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYC 207
            |...:..::|||.| |....|...:|:.|....::|.:|..|:||||:||:|||.:||..:|.:|
  Rat   153 EKKSVKTVNQLAHALHQDEQLHAGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFC 217

  Fly   208 MDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERC 272
            :|||||:||.|:|||:.:.|:|||..|:.:|||||:|||||||| ||:.|||..::|:.||||||
  Rat   218 LDADVFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWD-ASASEPEYMEEVRRQHMERC 281

  Fly   273 VNLLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITN-PSG------QTQQRYQEFLRFENDF 330
            .:.|||||||...|| |.:||:.|||.|.|..|..:... |.|      ..|.|..||..||..|
  Rat   282 TSFLVDELGVVDRAQ-AGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERRF 345

  Fly   331 SNCLAVSALKTKFGPHLLSAQKILNQLK----STLICPFIEKVSRLIDENKERRANLNAEIEDWL 391
            ..|::.||:||||..|.:.|::|...::    |..|....::|..|  |.:|.|.:....|:..|
  Rat   346 EECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHIAAQEQRVYCL--EMREERQDRLRFIDKQL 408

  Fly   392 ILMQEDREALQYCFEELTEMTQRVGRCVLNDQIKTLIPSSVL--SFSQPFHPEFPAQIGQYQRSL 454
            .|:.:|   .:...:::||..:|.....:.::|:.|   |||  .:...|||. |..:..|:..|
  Rat   409 ELLAQD---YKLRIKQMTEEVERQVSTAMAEEIRRL---SVLVDEYQMDFHPS-PVVLKVYKNEL 466

  Fly   455 CAHLD----KLLEDRVLQCLSIPL---QRKILDIEKEIGLPIA-ENSCD-------WQLIYGLDC 504
            ..|::    :.:.||....::..|   |:.::|..|.: ||:: .|..|       :.|.|.|:|
  Rat   467 HRHIEEGLGRNMSDRCSTAIASSLQTMQQDMIDGLKPL-LPVSVRNQIDMLVPRQCFSLSYDLNC 530

  Fly   505 QSYMSDFQPDLRFRFSLGFTALWHRLEG---------------NLPLHASPFRIQKLQNGHKKCS 554
            ....:|||.|:.|.||||:|.|.:|..|               ..||..:|            .:
  Rat   531 DKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRALLGYNDQVQRPLPLTP------------AN 583

  Fly   555 P-LPPLVNGNHWQ--MLESLV------KSKGSLGTVLLSAMAIRSFNWPIVLILGGLVGSFYIYE 610
            | :|||..|:..|  ::.|:|      .|:.|:|.:::..:..::..|.::.:..||.|..|:||
  Rat   584 PSMPPLPQGSLTQEELMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYE 648

  Fly   611 YAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLATVRNCWEAQSNETLNDLNVR 675
            ...|||.|:||:||.|:.....::|:..:..|.|....|::|.|:........|.:.|.::|...
  Rat   649 RLTWTTRAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQE 713

  Fly   676 TAELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYLTKS 718
            .|.:.|::::::.||...|..|:|...|.|.|..|...||..|
  Rat   714 IAAMNKKVEALDSLQSKAKLLRNKAGWLDSELNMFIHQYLQPS 756

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.