DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzo and mfn2

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001121726.1	Gene:	mfn2 / 567448	ZFINID:	ZDB-GENE-081105-44	Length:	757	Species:	Danio rerio

Alignment Length:	751	Identity:	255/751 - (33%)
Similarity:	389/751 - (51%)	Gaps:	78/751 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSSRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETV-------LLKDRQMLEHLCAFSSRVEAI 78
            ::|.|..||.||.::..|:..|..|:......||||.       :..:.|:.| :..:.|:|..|
Zfish    25 NASPLKHFVTAKKKINGIFEQLGAYIKESSAFLEETYSNEELDPVTTEEQVAE-VRGYLSKVAGI 88

  Fly    79 AKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQED 143
            .:||||..|||.||||||||||:||||:|.:|:|||.:||||:||.:|:....||: .:..|..|
Zfish    89 GEVLSRRHMKVVFFGRTSNGKSSVINAMLWDKVLPSGIGHTTNCFLRVEGTDGNES-FLLTEGSD 152

  Fly   144 EHMELSALSQLASA-HSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYC 207
            |...:..::|||.| |....|...:|:.|...|.:|::|..|:||:|:||:|||.:||..:|.:|
Zfish   153 ERKSVKTVNQLAHALHQDEDLDAGSLVCVMWPKAKCALLRDDLVLVDSPGIDVTTELDSWIDKFC 217

  Fly   208 MDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERC 272
            :|||||:||.|:|||:.:.|:.||..|..:||.||:|||||||| ||:.|||..::|:.|||:||
Zfish   218 LDADVFVLVANSESTLMQTEKSFFHKVNERLSSPNIFILNNRWD-ASANEPEYMEEVRRQHMDRC 281

  Fly   273 VNLLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITNPSGQT----------QQRYQEFLRFE 327
            .:.|||||.|...: .|.:||:.|||.|.|..|   :....|..          |.|..||..||
Zfish   282 TSFLVDELRVVDRS-HAGDRIFFVSAKEVLQAR---VQKAQGMPEAGGALAEGFQARMFEFQNFE 342

  Fly   328 NDFSNCLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLI 392
            ..|..|::.||:||||..|...|::|...|:  ||   ::.|.....|.:.....:..|.||.|.
Zfish   343 RRFEECISQSAVKTKFEQHTTRAKQISEALR--LI---MDSVHIAAQEQRIHCLEMKEEREDRLE 402

  Fly   393 LMQEDREALQY-CFEELTEMTQRVGRCVLNDQIKTLIPSSVL--SFSQPFHPEFPAQIGQYQRSL 454
            .:.:..:.|.. |..::.::|:.|.:.|.|...:.:...:||  .|...|||. |..:..|:..|
Zfish   403 FIDKQLDLLTLDCKSKIKKITEEVEKQVSNAMAEEIRRLAVLVDDFHMDFHPS-PVVLKVYKNEL 466

  Fly   455 CAHLD----KLLEDRVLQCLSIPL---QRKILDIEKEIGLPI---------AENSCDWQLIYGLD 503
            ..|::    :.:.:|....:::.|   |..::|..|.: |||         ....| :.|.|.|:
Zfish   467 HRHIEEGLGRNMSERCSSAITVALQTTQTDMIDGLKPL-LPITIREQVDKMVPRQC-FALSYDLN 529

  Fly   504 CQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLHASPFRIQKLQNGHKKCSP-----------LP 557
            |....||||.|:.|.||||:|.|.:|..|       |...::...|:....|           :|
Zfish   530 CDKLCSDFQEDIGFHFSLGWTMLVNRFLG-------PKNTRRALMGYNDQVPRSLAITPVSTSMP 587

  Fly   558 PLVNGNHWQ--MLESLV------KSKGSLGTVLLSAMAIRSFNWPIVLILGGLVGSFYIYEYAAW 614
            |...|:..|  ::.|:|      .|:.|:|.:::..:..::..|.::.:..||.|..|:||...|
Zfish   588 PFPQGSMTQEELMVSMVTGLASLTSRTSMGIIVVGGVIWKAVGWRLIALSVGLYGLLYVYERLTW 652

  Fly   615 TTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLATVRNCWEAQSNETLNDLNVRTAEL 679
            ||.|:||:||.|:.....::|:..|..|.|....|::|.||:..:....|.:.|...|.....:|
Zfish   653 TTRAKERTFKRQFVDYASEKLQLIVSYTGSNCSHQVQQELASTFSQLCQQVDVTRQQLEDEIGDL 717

  Fly   680 TKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYL 715
            ..:|:.::.||...|..|:|...|.|.|..|.:.||
Zfish   718 NSKIEQLDTLQSKAKLLRNKAGWLDSELNMFIQQYL 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	119/257 (46%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	44/150 (29%)
mfn2	NP_001121726.1	DLP_2	97..349	CDD:206739	119/257 (46%)
mfn2	NP_001121726.1	Fzo_mitofusin	594..754	CDD:282633	46/160 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52369
OrthoDB	1	1.010	-	-		D117843at33208
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10465
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.890