DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and mfn1

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001016189.1	Gene:	mfn1 / 548943	XenbaseID:	XB-GENE-998114	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	769	Identity:	249/769 - (32%)
Similarity:	398/769 - (51%)	Gaps:	99/769 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ISSSSSSRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETVL---LKD---RQMLEHLCAFSSRV 75
            :..:|.|.|..||.||..:..|:..|..|:|..:|.:|||..   ||:   ...:..:.|..:::
Frog     1 MEEASVSPLKHFVLAKKSITSIFDQLVEYVSEGVTFVEETFQNPELKNVSTEDDVNKVKASKTKL 65

  Fly    76 EAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVE 140
            ..|.:||:|..||||||||||:|||.|||::|.:|:|||.:||||:||..|:.. ..:..::..|
Frog    66 AGIGEVLARRNMKVAFFGRTSSGKSTVINSMLWDKVLPSGIGHTTNCFLSVEGT-EGDKAYLMTE 129

  Fly   141 QEDEHMELSALSQLASA-HSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLD 204
            ..:|...:..::|||.| |....|....|:.|...|.:|::|..|:||:|:||.|||.:||..:|
Frog   130 GSEEKKSVKTVNQLAHALHMDKDLGAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWID 194

  Fly   205 SYCMDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHM 269
            .:|:|||||:||.|:|||:...|:.||..|..|||:||:|||||||| ||:.|||..:.|:.|||
Frog   195 KFCLDADVFVLVANSESTLMNTEKHFFYKVNEKLSKPNIFILNNRWD-ASASEPEYMEDVRKQHM 258

  Fly   270 ERCVNLLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITNPSGQTQ----------QRYQEFL 324
            |||.:.|||||.|..:. ||.:||:.|||.|.|   |.::....|..:          .|:.||.
Frog   259 ERCQSFLVDELKVVDSL-EAQKRIFFVSAKEVL---NARMHKAQGMPEAGAALAEGFHTRFLEFQ 319

  Fly   325 RFENDFSNCLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIED 389
            :||..|..|::.||:||||..|.::|::|.:.:|:.:....|:..        ::|.....|.|:
Frog   320 KFEKLFEECISQSAVKTKFEQHTITAKQITDTVKAIMDAINIKAA--------DKRVRCMVEREN 376

  Fly   390 WLILMQEDREALQYCFEELTEMTQRVGRCVL------NDQIKTLIPSSVL-------SFSQPFHP 441
                 |.||  |:|...::..:|:.:.:.:|      |:|:.:.:...:.       .|...|||
Frog   377 -----QNDR--LEYVKTQMLILTEEIEKRILHITKEVNEQVSSAMMDEIYHLSLLVDKFDAEFHP 434

  Fly   442 EFPAQIGQYQRSLCAHLD----KLLEDRVLQCLSIPLQRKILDI--------------EKEIGLP 488
            .. :.:..|:..|..|::    :.|.||....:::.:|:...||              :..|.||
Frog   435 SL-SVLKLYKNELNLHIENGMGRKLADRCSNAVNMSIQKAQEDIIDKLMPLLPPSVQDQTTISLP 498

  Fly   489 IAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLH-----ASP-FRIQK-L 546
            ..:    :.|.|.::|:...||||.|:.||||.|.|:|.:|..|....|     |.| |:|.: :
Frog   499 CKK----FDLSYNINCEKLCSDFQEDVEFRFSFGLTSLANRFLGCKTSHLLLGFAEPMFQIPRPV 559

  Fly   547 QNGHKKCSP-LPPLVNGNHWQMLESL-----VKSKGSLGTVLLSAMAIRSFNWPIV----LILGG 601
            .......:| |||........||..:     :.|:||:..:::..:..|:..|.::    |..||
Frog   560 STPSATGNPVLPPQPASQEELMLSVMSGLASLTSRGSMSVIIVGGVIWRTVGWRLISGMMLAYGG 624

  Fly   602 LVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLATV--RNCWEAQ 664
            |    |:||...|||.|:||:||.|:.....|:|:..|..|.:....|:::.|...  |.|  .|
Frog   625 L----YLYERLTWTTRAKERAFKKQFVNYAAQKLKLIVSFTSANCSQQVQKELDNTFKRLC--QQ 683

  Fly   665 SNETLNDLNVRTAELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYLTKS 718
            .:.|..||.....:|:::|..:|.:|.:.|..|::...:...|.:|.:::|.::
Frog   684 VDVTERDLAESIDKLSEEIHQLEQIQSNSKALRNRASRIEGELRNFAKSFLPQN 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	117/257 (46%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	41/149 (28%)
mfn1	NP_001016189.1	DLP_2	77..329	CDD:206739	117/257 (46%)
mfn1	NP_001016189.1	Fzo_mitofusin	575..734	CDD:368125	43/164 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D117843at33208
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10465
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110