DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and OPA1

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_570850.2	Gene:	OPA1 / 4976	HGNCID:	8140	Length:	1015	Species:	Homo sapiens

Alignment Length:	742	Identity:	136/742 - (18%)
Similarity:	253/742 - (34%)	Gaps:	206/742 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SSSSSRLSEFVDAKTELQDIYHDLSNYLSNFLTILE----------ETVLLKDRQMLEHLCAFSS 73
            |:|.::....|..|.::..:..:|.:....:..|||          :.||.||.:.:.|.....|
Human   254 STSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKS 318

  Fly    74 RVEAIAKVL-----------SRDRM-KVAFFGRTSNGKSAVINALLHEKILPSAMGH--TTSCFC 124
            .::..::||           ::|.: :|...|..|.||::|:..:...:|.|...|.  |.|
Human   319 LIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRS--- 380

  Fly   125 QVQANGSNETEHVKV-EQEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKN---RCSILDYDV 185
            .|:...|....||.: :......:|:....||      ||:..  :::.|.||   .|::....:
Human   381 PVKVTLSEGPHHVALFKDSSREFDLTKEEDLA------ALRHE--IELRMRKNVKEGCTVSPETI 437

  Fly   186 ------------VLMDTPGV----------DVTAQLDDCLDSYCMDADVFILVLNAESTVSRVER 228
                        ||:|.|||          |....:.....:|..:.:..||.:...|.  ..||
Human   438 SLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV--DAER 500

  Fly   229 QFFKDVASKL---SRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYSTAQEAW 290
            ....|:.|::   .|..:|:|..                        |:|....:...|..|:..
Human   501 SIVTDLVSQMDPHGRRTIFVLTK------------------------VDLAEKNVASPSRIQQII 541

  Fly   291 E-RIYHVSALEALHIRNGQITNPSGQTQQRYQEFLRFENDF---SNCLAVSALKTKFGPHLLSAQ 351
            | :::.:.||....:..|:     |.:.:..:....:|.:|   |..|..|.||.    |.::.:
Human   542 EGKLFPMKALGYFAVVTGK-----GNSSESIEAIREYEEEFFQNSKLLKTSMLKA----HQVTTR 597

  Fly   352 KILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQRVG 416
            .:...:.........|.|.:..|..|..|.||..|   |           :..:..|.|:    .
Human   598 NLSLAVSDCFWKMVRESVEQQADSFKATRFNLETE---W-----------KNNYPRLREL----D 644

  Fly   417 RCVLNDQIKTLIPSSVLSFSQ--PFHPEFPAQIGQYQRSLCAHLDKLLEDRVLQCLSIPLQRKI- 478
            |..|.::.|..|...|:|.||  |.|.|...|...::|         :...|::.:.:|..:.:
Human   645 RNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWER---------VSTHVIENIYLPAAQTMN 700

  Fly   479 -------LDI------EKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRL 530
                   :||      :|:  ||.......|:.:     |...|.|..:.:.:
Human   701 SGTFNTTVDIKLKQWTDKQ--LPNKAVEVAWETL-----QEEFSRFMTEPKGK------------ 746

  Fly   531 EGNLPLHASPFRIQKLQNGHKKCSPLPPLVNGNHWQMLESLVKSKGSLGTVLLSAMAIRSFN--- 592
                 .|...|  .||:...|:.|     :..:.|...     ::.||..:..:|:..||.:
Human   747 -----EHDDIF--DKLKEAVKEES-----IKRHKWNDF-----AEDSLRVIQHNALEDRSISDKQ 794

  Fly   593 -WPIVL----------------ILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQ 640
             |...:                .:..:||..:...:..|....||:...::....|::.|:.:.:
Human   795 QWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEE 859

  Fly   641 QTVSGFELQLRQHLATVRNCWEAQSNE 667
            ...    ......:.|||...|::..|
Human   860 HPA----YLASDEITTVRKNLESRGVE 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	54/282 (19%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	18/116 (16%)
OPA1	NP_570850.2	DLP_1	342..616	CDD:206738	60/319 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900