DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and opa1

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_009300789.1	Gene:	opa1 / 492332	ZFINID:	ZDB-GENE-041114-7	Length:	1034	Species:	Danio rerio

Alignment Length:	734	Identity:	139/734 - (18%)
Similarity:	240/734 - (32%)	Gaps:	191/734 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SSSSSSRLS---EFVD------AKTELQDIYHDLSNYLSNFLTILEETVLLKDRQMLEHLCAFSS 73
            |.|.|.|.|   |.||      .:|:|:  |..:...|......|.:.||.||.:.:.......|
Zfish   275 SPSQSKRKSSDKEKVDQLQEELLRTQLK--YQRMLERLEKENKELRKVVLQKDDKGIHQRKVKKS 337

  Fly    74 RVEAIAKVL-----------SRDRM-KVAFFGRTSNGKSAVINALLHEKILPSAMGH--TTSCFC 124
            .::..::||           ::|.: :|...|..|.||::|:..:...:|.|...|.  |.|
Zfish   338 LIDMYSEVLDILSDYDSNYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRS--- 399

  Fly   125 QVQANGSNETEHVKV-EQEDEHMELSALSQLA------------SAHSPGALKPSTLLQVNMAKN 176
            .|:...|....||.: :......:|.....||            |......:.|.|   ::::..
Zfish   400 PVKVTLSEGPHHVAMFKDSSREFDLGKEEDLAALRHEIELRMRKSVKEGQTVSPET---ISLSVK 461

  Fly   177 RCSILDYDVVLMDTPGVDVTAQLDDCLD----------SYCMDADVFILVLNAESTVSRVERQFF 231
            ...|  ..:||:|.|||..|.......|          :|..:.:..||.:...|.  ..||...
Zfish   462 GPGI--QRMVLVDLPGVISTVTTGMAADTKETIFSISKAYMQNPNAIILCIQDGSV--DAERSIV 522

  Fly   232 KDVASKL---SRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYSTAQEAWE-R 292
            .|:.|::   .:..:|:|..                        |:|....|...|..|:..| :
Zfish   523 TDLVSQMDPQGKRTIFVLTK------------------------VDLAEKNLASPSRIQQIVEGK 563

  Fly   293 IYHVSALEALHIRNGQITNPSGQTQQRYQEFLRFENDF---SNCLAVSALKTKFGPHLLSAQKIL 354
            ::.:.||....:..|:     |...:.......:|.||   |..|....||.    |.::.:.:.
Zfish   564 LFPMKALGYFAVVTGK-----GSPNESIDSIKDYEEDFFQNSRLLKDGMLKA----HQVTTKNLS 619

  Fly   355 NQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQRVGRCV 419
            ..:.........|.|.:..|..|..|.||..|   |           :..:..|.|:    .|..
Zfish   620 LAVSDCFWKMVRESVEQQADAFKASRFNLETE---W-----------KNNYPRLREL----DRNE 666

  Fly   420 LNDQIKTLIPSSVLSFSQ--PFHPEFPAQIGQYQRSLCAHLDKLLEDRVLQCLSIPLQRKILDIE 482
            |.::.|..|...|:|.||  |.|.|             :.|.|.|.:||           ...:.
Zfish   667 LYEKAKNEILDEVISLSQVTPKHWE-------------SILQKKLWERV-----------STHVI 707

  Fly   483 KEIGLPIAE--NSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLHASPFR--- 542
            :.|.||.|:  ||..:.....:..:.:.....|......:      |..|:.......:.::
Zfish   708 ENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPHKALEVA------WETLQEEFARFMAEYKGKD 766

  Fly   543 ----IQKLQNGHKKCSPLPPLVNGNHWQMLESLVKSKGSLGTVLLSAMAIRSF----NWPIVL-- 597
                ..||:...|..|     :..:.|.     .::..||..:..:|:..||.    .|...:
Zfish   767 QDDIFDKLKEAVKDES-----IKRHKWN-----ERAMDSLRVIQHNALEDRSITDKPQWDAAIQF 821

  Fly   598 --------------ILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFEL 648
                          ::..:||..:...:.:|.....|:..:::....|::.|:.....|.    .
Zfish   822 MEETLQSRLKDTESVIADMVGPDWKQRWMSWKNRTPEQHTRNETKNELERLLKLHEDHTA----Y 882

  Fly   649 QLRQHLATVRNCWEAQSNE 667
            .....:.|||...||:..|
Zfish   883 LANDEVTTVRKNLEARGVE 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	54/279 (19%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	19/116 (16%)
opa1	XP_009300789.1	DLP_1	361..635	CDD:206738	59/316 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900