DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fzo and MX1

DIOPT Version :9

Sequence 1:NP_732840.1 Gene:fzo / 42745 FlyBaseID:FBgn0011596 Length:718 Species:Drosophila melanogaster
Sequence 2:NP_001138397.1 Gene:MX1 / 4599 HGNCID:7532 Length:662 Species:Homo sapiens


Alignment Length:363 Identity:73/363 - (20%)
Similarity:133/363 - (36%) Gaps:85/363 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 VAFFGRTSNGKSAVINALLHEKILPSAMGHTTSC--FCQVQANGSNETEHVKVEQEDEHMELSAL 151
            :|..|..|:|||:|:.| |....||...|..|.|  ..:::...:.:....||..:|..:|:|..
Human    73 IAVIGDQSSGKSSVLEA-LSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDA 136

  Fly   152 SQLASAHSPGALKPSTLLQVNMAKN----------------RCSILDY-DVVLMDTPGVDVTAQL 199
            |::..             ::|.|:|                ..|..|. |:.|:|.||:...|  
Human   137 SEVEK-------------EINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVA-- 186

  Fly   200 DDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKV 264
                            |.|..:.:....:...|....:....:|.::.:..|.|::....|.|:|
Human   187 ----------------VGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEV 235

  Fly   265 KDQHMERCVNL-----LVDELGVYSTAQEAWERIYHVSALEALHIRNG-QITNPSGQTQQRYQEF 323
             |...:|.:.:     |||        :...:::..|......|::.| .|....|  ||..|:.
Human   236 -DPEGDRTIGILTKPDLVD--------KGTEDKVVDVVRNLVFHLKKGYMIVKCRG--QQEIQDQ 289

  Fly   324 LRFENDFSNCLAVSALKTKFGPH-----LLSAQK-----ILNQLKSTLICPFIEKVSRLIDENKE 378
            |....      |:...|..|..|     ||...|     :..:|.|.||....:.:..|.::.||
Human   290 LSLSE------ALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKE 348

  Fly   379 RRANLNAEIEDWLILMQED-REALQYCFEELTEMTQRV 415
            ....:..|::.:.:.:.|| .|.:.:..:::....|.:
Human   349 THQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDI 386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzoNP_732840.1 DLP_2 87..334 CDD:206739 54/269 (20%)
Fzo_mitofusin 572..716 CDD:282633
MX1NP_001138397.1 DLP_1 68..340 CDD:206738 65/315 (21%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 77..84 3/6 (50%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 102..104 0/1 (0%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 178..181 1/2 (50%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 247..250 0/2 (0%)
Dynamin_M 260..546 CDD:395818 28/135 (21%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 279..282 0/2 (0%)
Bundle signaling element (BSE) 341..366 4/24 (17%)
Middle domain 366..533 4/21 (19%)
Stalk 367..632 3/20 (15%)
Critical for lipid-binding 554..557
GED 571..660 CDD:128597
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0699
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.