DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and shi

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster

Alignment Length:	832	Identity:	142/832 - (17%)
Similarity:	272/832 - (32%)	Gaps:	292/832 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LSNFLTILEETVLLKDRQMLEHLCAFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEK 110
            :.:.:||:.:   |:|        ||:|    :...:..|..::|..|..|.|||:|:...:.:.
  Fly     1 MDSLITIVNK---LQD--------AFTS----LGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKD 50

  Fly   111 ILPSAMGHTT---------------SCFCQVQANGSNETEHVKVEQEDEHMELSALSQLASAHSP 160
            .||...|..|               ..|..::....:..:.::.|.|||...::
  Fly    51 FLPRGSGIVTRRPLILQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVT----------- 104

  Fly   161 GALKPSTLLQVNMAKNRCSILDYDVVLMDTPG----------VDVTAQLDDCLDSYCMDADVFIL 215
            |:.|..:.:.:|:......:|  ::.|:|.||          ||:..|:...:..:.......||
  Fly   105 GSNKGISNIPINLRVYSPHVL--NLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLIL 167

  Fly   216 VLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLL--VD 278
            .:...:|                            |.|:|...::.::|..|.: |.:.::  :|
  Fly   168 AVTPANT----------------------------DLANSDALKLAKEVDPQGV-RTIGVITKLD 203

  Fly   279 ELGVYSTAQEAWERIYHVSALEALHIRNGQITNPSGQTQQRYQEFLRFENDFSNCLAVSA----- 338
            .:...:.|::..|.       :.|.:|.|.|     ....|.|:.:....|....||...
  Fly   204 LMDEGTDARDILEN-------KLLPLRRGYI-----GVVNRSQKDIEGRKDIHQALAAERKFFLS 256

  Fly   339 ------LKTKFG-PHLLSAQKILNQ-----LKSTLICPFIEKVSRLIDENKERRANLNAEIEDWL 391
                  :..:.| |:|   |::|||     ::.||        ..|.|:.:::...|..|:|::.
  Fly   257 HPSYRHMADRLGTPYL---QRVLNQQLTNHIRDTL--------PGLRDKLQKQMLTLEKEVEEFK 310

  Fly   392 ILMQEDR-----------EALQYCFEELTEMTQRVGRCVLNDQIKTLIPSSVLSFSQPFHPEFPA 445
            .....|.           :.||..||...|.:   |..::|    |...|.....::.||.....
  Fly   311 HFQPGDASIKTKAMLQMIQQLQSDFERTIEGS---GSALVN----TNELSGGAKINRIFHERLRF 368

  Fly   446 QIGQY---QRSLCAHLD----------------------------KLLEDRVLQCLSIPLQ---- 475
            :|.:.   ::.|...:.                            .||::.|::|:.:.:|
  Fly   369 EIVKMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSV 433

  Fly   476 -------------RKILDIEKEIGLPI--AENSCDWQLIYGLDCQ-SYMSDFQPDLRFRFSLGFT 524
                         |...:.|:.|...:  .|:||..|::..:|.: :||:....|.     :||.
  Fly   434 VVRMCTAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTNHEDF-----IGFA 493

  Fly   525 ALWHRLE----------GNLPLHASPFRIQKL---------QNGHKKCSPLPPLVNGN--HWQML 568
            ...::.|          ||..:......||.|         ::|........|...|:  :|.:|
  Fly   494 NAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVL 558

  Fly   569 ESLVKSKGSLGTVLLSAMAIRSFNW---------PIVLILGGL---------------------- 602
            .|                  .|.:|         ..:|.|.||
  Fly   559 TS------------------ESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFS 605

  Fly   603 -----VGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQT-------VSGFELQLRQHLA 655
                 |...|.....:..|.....|:|:.:.|......:.:.|:.       .|..:.||.:.:.
  Fly   606 PDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDPQLERQVE 670

  Fly   656 TVRNCWEAQSNETLNDLNVR-TAELTKQIQSMEVLQLSLKKFRD--KGQLLA 704
            |:||         |.|..:: ..:.|:.:....::.|.:...:|  .|:|||
  Fly   671 TIRN---------LVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLA 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	46/273 (17%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	28/179 (16%)
shi	NP_001259588.1	DYNc	1..240	CDD:197491	53/307 (17%)
		CrfC	73..>498	CDD:223771	83/501 (17%)
		Dynamin_M	212..498	CDD:279383	56/320 (18%)
		PH_dynamin	512..644	CDD:269958	22/149 (15%)
		PH	552..638	CDD:278594	14/103 (14%)
		GED	664..755	CDD:128597	14/59 (24%)
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900