DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and mfn1b

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_017213868.2	Gene:	mfn1b / 393620	ZFINID:	ZDB-GENE-040426-1553	Length:	745	Species:	Danio rerio

Alignment Length:	766	Identity:	250/766 - (32%)
Similarity:	389/766 - (50%)	Gaps:	104/766 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETVL------LKDRQMLEHLCAFSSRVEAIAKV 81
            |.|..||.||.::.:::..|..|:......::||..      :.::..|:.:.:::|::..|.:|
Zfish     7 SPLKRFVLAKKKISEVFEQLLVYVQEGCEFVKETCANESLENIANKDQLDEIESYTSKLSIIQEV 71

  Fly    82 LSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETE-HVKVEQEDEH 145
            |:|..||||||||||||||.||||:|.:::|||.:||||:||..|:  |::|.: .:|.|..:|.
Zfish    72 LARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVE--GTDEDKAFLKTEGSEEE 134

  Fly   146 MELSALSQLASA-HSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMD 209
            ..:..::|||.| |...:|....|::|...|.:|::|..|:||:|:||.|||.:||..:|.:|:|
Zfish   135 KSIKTVNQLAHALHMDESLDAGCLVKVFWPKTKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLD 199

  Fly   210 ADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVN 274
            ||||:||.|:|||:...|:.||..|..|||:||:|||||||| ||:.|||..:.|:.||.:||||
Zfish   200 ADVFVLVANSESTLMNTEKHFFHKVNEKLSKPNIFILNNRWD-ASAAEPEYMEDVRKQHTDRCVN 263

  Fly   275 LLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITNPSGQT----------QQRYQEFLRFEND 329
            .||:||.|...|| |..||:.|||.|.|   |.::....|..          |.|.:||..||..
Zfish   264 FLVEELKVVDRAQ-APNRIFFVSAKEVL---NSRMQRAQGMPETGGALAEGFQDRLKEFQNFERS 324

  Fly   330 FSNCLAVSALKTKFGPHLLSAQKILNQLKSTL----------ICPFIEKVSRLIDENKERRANLN 384
            |..|::.||:||||..|.:.|::|...:|..:          ....:|:...|||.....|..||
Zfish   325 FEECISHSAVKTKFEQHTIRAKQITETVKDIMDQINITAAEKRVVSLEEREYLIDRLDFVRNQLN 389

  Fly   385 AEIEDWLILMQEDREALQYCFEELTEMTQRVGRCVLNDQIKTLIPSSVL--SFSQPFHPEFPAQI 447
            ..|:|              ..:::..:|:.|...|.|...:.:...||:  .|...|||. |..:
Zfish   390 LLIQD--------------IKKKIKAITEEVENKVSNAMAEEICRLSVIIDEFRSDFHPS-PQML 439

  Fly   448 GQYQRSLCAHLDKLL-------------------EDRVLQCLSIPLQRKILDIEKEIGLPIAENS 493
            ..|:..|.:|:::.:                   :..:::||. ||.......:..:.:|    |
Zfish   440 KMYKSDLLSHIEQGMGKNLAFRCSDAVNASVQCSQQDMIECLK-PLLPSAAQTQLHMLIP----S 499

  Fly   494 CDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLHASPFRI---QKLQNGHKKCSP 555
            ..::|.|.|:|.:..||||.::.|:||||::||.||..|  |::|....:   |.||........
Zfish   500 RKFELSYDLNCATLCSDFQENIEFQFSLGWSALVHRFLG--PVNAKRALMLVDQNLQLTAPTTPT 562

  Fly   556 LPPLVNGNHWQML---------ESL----------VKSKGSLGTVLLSAMAIRSFNWPIVLILGG 601
            .|.:|...:.:.|         |.|          |.|:.|:..:::..:..|:..|.::.:...
Zfish   563 APAVVQSQNSRALGQNQASVTQEELMLTMVNNLASVTSRTSMSVIIVGGVVWRTVGWRLIALSMS 627

  Fly   602 LVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLAT--VRNCWEAQ 664
            :.|..|:||...|||.|:||:.|.|:.....::|:..:..|.|....|::|.:|:  .|.|  .|
Zfish   628 MYGLLYLYERLTWTTKAKERALKKQFVDYATEKLQMIISFTSSNCSHQVQQEIASTFARLC--QQ 690

  Fly   665 SNETLNDLNVRTAELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYL 715
            .:.|..||......||.:||.:|.:|...|..|.|...|..:|.||...||
Zfish   691 VDITQRDLESDIQRLTDKIQKLETVQNRSKVLRHKATALEMQLEDFSSQYL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	122/258 (47%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	44/146 (30%)
mfn1b	XP_017213868.2	DLP_2	77..329	CDD:206739	122/258 (47%)
		Transposase_22	306..>408	CDD:308569	29/115 (25%)
		Fzo_mitofusin	582..742	CDD:309784	46/162 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52369
OrthoDB	1	1.010	-	-		D117843at33208
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10465
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030