DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and mxd

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_695562.6	Gene:	mxd / 360146	ZFINID:	ZDB-GENE-030721-8	Length:	644	Species:	Danio rerio

Alignment Length:	470	Identity:	95/470 - (20%)
Similarity:	158/470 - (33%)	Gaps:	137/470 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 VAFFGRTSNGKSAVINALLHEKILPSAMGHTTSC-------------------FCQVQANGSNET 134
            :...|..|:|||:|:.| |....||...|..|.|                   :..|::....:.
Zfish    67 IVVIGDQSSGKSSVLEA-LSGVALPRGSGIVTRCPLELRLRKVTGVKWKAVLTYRSVKSRPDKQG 130

  Fly   135 EHVKV-EQED----EHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPG-- 192
            .::|. |.||    |.....|.::|| ....|.......|:| |:|:.|     |:.|:|.||
Zfish   131 NNLKTFEFEDSSIVEKHVTDAQNELA-GKGVGICDDLITLEV-MSKDVC-----DLTLIDLPGIV 188

  Fly   193 -VDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSL 256
             |.|..|.:|..|                    :::|...|.: .|....||.::....|.|::.
Zfish   189 RVPVAGQPEDVGD--------------------QIKRLIMKYI-MKRETINLVVVPCNIDIATTE 232

  Fly   257 EPEMEQKVKDQHMERCVNL----LVD---ELGVYSTAQEAWERIYHVSALEALHIRNG-QITNPS 313
            ...|.|.|..:.:.....|    |:|   |.|:....|.           :.:|:|.| .:....
Zfish   233 ALRMAQNVDPEGIRTVAILTKPDLIDKGTEKGILKVVQN-----------KVIHLRKGYTMVKCR 286

  Fly   314 GQTQ-----------QRYQEFLRFENDFS----------NCLAVSALKTKFGPHLLSAQKILNQL 357
            ||.|           :..:||.:..:.|.          .||||...|........|.|::.:|:
Zfish   287 GQQQINDRITLEEALEEEKEFFQNHDTFRCLLSENKATIKCLAVKLTKDLVDHIKNSLQRVDDQV 351

  Fly   358 KSTL------------------------ICPFIEKVSRLIDE--------NKERRANLNAEIEDW 390
            |..|                        :...|:|.:.::..        |:...|.|..|.:.|
Zfish   352 KKLLWDVKNELKECEGGPPQDPKGAKQFLIKTIKKFNDIVTSMSSGELMLNENLFAELRGEFKKW 416

  Fly   391 LILMQEDREALQYCFEELTEMTQRVGRCVLNDQI-KTLIPSSVLSFSQPFHPEFPAQIGQYQRSL 454
            ...:::.:....|..|.:.:...|......|.:: :|::...|....:|     ...:......:
Zfish   417 NDHLEQKKSPFNYSKELMKKNRGRELHGFSNYKLFETILQDHVAQLKEP-----AINLLHKANGI 476

  Fly   455 CAHLDKLLEDRVLQC 469
            .|   |.|.|||.||
Zfish   477 IA---KHLTDRVSQC 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	63/300 (21%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633
mxd	XP_695562.6	DLP_1	62..344	CDD:206738	68/316 (22%)
		Dynamin_M	266..544	CDD:279383	42/242 (17%)
		GED	564..643	CDD:280391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900