DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzo and mxc

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001007285.1	Gene:	mxc / 360145	ZFINID:	ZDB-GENE-030721-7	Length:	626	Species:	Danio rerio

Alignment Length:	696	Identity:	120/696 - (17%)
Similarity:	226/696 - (32%)	Gaps:	223/696 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 VAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQ-------ANGS------NETEHVKVE 140
            :|..|..|:|||:|:.| |....||..:|..|.|...::       .|.|      ::||.:|..
Zfish    46 IAVIGDQSSGKSSVLEA-LSGVALPRGIGIVTRCPLILKLKKITRDKNWSGLLTYKDQTEILKEP 109

  Fly   141 QEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGV----------DV 195
            ...|:..|.|  |:|.|.:...:...   .:.:....|.:  .|:.|:|.||:          |:
Zfish   110 TGIENAVLKA--QIALAGTGEGISHE---MITLEIQSCDV--PDLTLIDLPGIARVATGNQPEDI 167

  Fly   196 TAQLDDCLDSYCMDAD-VFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPE 259
            ..|:.|.::.:....: :.::|:.|...::..|............:..|.||.         :|:
Zfish   168 EKQIKDLIEKFIKRQETISLVVVPANIDIATTEALKMASTVDPTGQRTLCILT---------KPD 223

  Fly   260 MEQKVKDQHMERCVNLLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITNPSGQTQQRYQEFL 324
            :..:..:..:.|.||                                              .|.:
Zfish   224 LVDRGMEDTVVRTVN----------------------------------------------NEVI 242

  Fly   325 RFENDFS--NCLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEI 387
            |.|..:.  .|.....:..|           ||.:::      :||..|..||:.:
Zfish   243 RLEKGYMIVKCRGQQDINDK-----------LNLVEA------LEKERRFFDEHPQ--------- 281

  Fly   388 EDWLILMQEDREALQYCFEELT-EMTQRVGRCV--LNDQI-----KTLIPSSVLSFSQPFHPEFP 444
              :..|:::.:..:....:.|| |:.:.:.:.|  |.:||     ||.....||..|.|...|.
Zfish   282 --FSSLLEDGKATIPLLGQRLTEELVEHIAKNVPRLQNQIEMKLQKTFERLKVLGESVPDDDEI- 343

  Fly   445 AQIGQYQRSLCAHLDKLLEDRVLQCLSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMS 509
                        .|:..|..::.|.:.  ...::..:|:|   |:..::    .::....|.::|
Zfish   344 ------------ELNNFLIKKLRQFMD--ALEEVKRVEEE---PVKSDT----RVFSKIRQEFVS 387

  Fly   510 DFQPDLRFRFSLGFTALWHRLEGNLPLHASPFRIQKLQNGHKKCSPLPPLVNGNHWQMLESLVKS 574
                             |..:..:.|:..|. .:|:....|:. ..||..:|
Zfish   388 -----------------WKHILDSKPIKMST-DLQEYVRTHRG-KELPGFLN------------- 420

  Fly   575 KGSLGTVLLSAMAIRSFNWPIVLILG----------GLVGSFYIYEYAAWTTAAQERSFKSQYAR 629
            .|:...::  .|.:.....|.:.:|.          |.:.:.:...|.....|.:|...|..:.:
Zfish   421 YGTFAGII--RMHVEDLEEPALKLLRNAKDIVHSSVGSIANIHFNGYPNLLLAVKEPIEKCLHEQ 483

  Fly   630 L--LQQRLRSD--VQQTVSGFELQLRQHL------ATVRNCWEAQ-SNETLND--------LNVR 675
            .  .::::||.  :::||...:.....||      .|||...||. .|..|.:        |.:.
Zfish   484 FQNAEEKIRSQFKLEKTVYCQDDLYTNHLNLLRPKNTVRFGLEASLGNSELRETAFHLTSYLTIA 548

  Fly   676 TAELTKQI-------------QSMEVLQLSLKKFRDKGQLLASRLG 708
            ...|..||             ..::...|.|....|.|.||....|
Zfish   549 CERLANQIPLIVQYHMMNEYNSQLQNAMLGLIGTSDPGMLLCEDSG 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	47/270 (17%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	33/179 (18%)
mxc	NP_001007285.1	DLP_1	41..313	CDD:206738	60/357 (17%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	50..57		3/6 (50%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	75..77		0/1 (0%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	151..154		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	220..223		0/11 (0%)
		Dynamin_M	234..516	CDD:279383	61/411 (15%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	252..255		1/2 (50%)
		GED	532..619	CDD:280391	12/63 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900