Protein Alignment fzo and Drp1

DIOPT Version :10

• Sequence 1: NP_732840.1
• Gene: fzo / 42745
• FlyBaseID: FBgn0011596
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Alignment Length: 708
• Identity: 122/708 - (17%)
• Similarity: 220/708 - (31%)
• Gaps: 254/708 - (35%)

  Fly    65 LEHLCAFSSRVEAIAKVLSRDRM---KVAFFGRTSNGKSAVINALLHEKILPSAMG--------- 117
            :|.|....::::.:...:..|.:   ::...|..|:|||:||.:::....||...|
  Fly     1 MEALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65

  Fly   118 -----------------------------HTTSCFCQVQANGSNETEHVKVEQEDEHMELSALSQ 153
                                         ||..||        .:.:.::.|.|:| .|.:|.|.
  Fly    66 QLIYSPLDDRENRSAENGTSNAEEWGRFLHTKKCF--------TDFDEIRKEIENE-TERAAGSN 121

  Fly   154 LASAHSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGV----------DVTAQLDDCLDSYCM 208
            ......|..||..:...||:            .|:|.||:          |:.||:.:.:..|..
  Fly   122 KGICPEPINLKIFSTHVVNL------------TLVDLPGITKVPVGDQPEDIEAQIKELVLKYIE 174

  Fly   209 DADVFILVLNAEST--VSRVERQFFKD----------VASKLS-------------------RPN 242
            :.:..||.:.|.:|  .:....:..||          |.:||.                   :..
  Fly   175 NPNSIILAVTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLG 239

  Fly   243 LFILNNRWDKASSLEPEMEQKVKDQ--HMERCVNLLVDELGVYSTAQEAWERIYHVSALEALHIR 305
            :..:.||..|....:..::.::||:  .::|....|....|....|:.....:.|       |||
  Fly   240 IIGVMNRSQKDIMDQKHIDDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMH-------HIR 297

  Fly   306 N----------------GQITNPSGQ-TQQRYQEFLRFENDFSN--CLAVSA----LKT------ 341
            :                ..:.|..|: ...:.|..|:....||:  |..:..    ::|
  Fly   298 DCLPDLKTRVNIMATQFQSLLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGG 362

  Fly   342 ---------KFGPHL--------LSAQKILNQLKS------TLICP------FIEKVSRLIDENK 377
                     .||..|        ||...||..:::      .|..|      .:::..|.::|..
  Fly   363 ARMGYIFHETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPS 427

  Fly   378 ERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQRVGRC------VLNDQIKTLIPSS----- 431
            .|...|         :.:|.:..:|:|..|:.:...|..:.      |:...::..:|.:
  Fly   428 LRCVEL---------IHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVE 483

  Fly   432 -----VLSFSQPFHPEFPAQIGQYQRSLCAHLDKLLEDRVLQCLSIPL------QRKILDIEKEI 485
                 .|::....||:|             |.|..|...:|:..|.|.      ||:.......:
  Fly   484 NIVAIELAYINTKHPDF-------------HKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHM 535

  Fly   486 GLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLHAS----------P 540
            ...|:.:|.      |..........||:...:.........|..|.:.|..||          |
  Fly   536 SPQISSHSA------GSQQPQQQQPPQPNSSQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAP 594

  Fly   541 FRIQKLQNG------HKK-CSPLPPL-----VNGNH------------WQMLESLVKS 574
            .|...::|.      |.. .||:.|:     |..||            ..::|.|:||
  Fly   595 TRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLIKS 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	61/349 (17%)
		Fzo_mitofusin	566..716	CDD:461432	4/9 (44%)
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	55/305 (18%)
		Dynamin_M	224..507	CDD:460033	47/311 (15%)
		GED	639..729	CDD:460495	4/14 (29%)