DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and Mx2

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_599177.2	Gene:	Mx2 / 286918	RGDID:	628821	Length:	659	Species:	Rattus norvegicus

Alignment Length:	721	Identity:	139/721 - (19%)
Similarity:	246/721 - (34%)	Gaps:	210/721 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DLSNYLSNFLTILEETVLLKDRQMLEHLCA-FSSRVEAIAKVLSRDRM----------KVAFFGR 94
            ||.|..|..|...|..|...::..|.:||: :..:|.....::...|.          .:|..|.
  Rat    12 DLVNLPSVPLPDGEAGVGENNKDSLNNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGD 76

  Fly    95 TSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEH--VKVEQEDEHMELSALSQLASA 157
            .|:|||:|:.| |....||...|..|.|...::....|:.|.  .||..:|..:|||..|::..|
  Rat    77 QSSGKSSVLEA-LSGVALPRGSGIVTRCPLVLKLKKLNQGEEWKGKVTYDDIEVELSDPSEVEEA 140

  Fly   158 HSPGALKPSTLLQVNMAKNRCSILDY------------DVVLMDTPGVDVTAQLDDCLDSYCMDA 210
            .:.|        |.::|.....|.|.            |:.|:|.||:...|
  Rat   141 INTG--------QNHIAGVGLGISDKLISLDVSSPHVPDLTLIDLPGITRVA------------- 184

  Fly   211 DVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNL 275
                 |.|..:.:.|..::...:...|....||.::.:..|.|::....|.||| |...:|.:.:
  Rat   185 -----VGNQPADIGRQIKRLITNYIQKQETINLVVVPSNVDIATTEALSMAQKV-DPDGDRTIGI 243

  Fly   276 -----LVDELGVYSTAQEAWERIYHVSALEALHIRNG-QITNPSGQTQQRYQEFLRFENDFSNCL 334
                 |||        :...:::..|......|::.| .|....|  ||..||.|      |...
  Rat   244 LTKPDLVD--------RGTEDKVVDVVRNLVCHLKKGYMIVKCRG--QQDIQEQL------SLAE 292

  Fly   335 AVSALKTKFGPH-----LLSAQK-----ILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIED 389
            |:...:..|..|     ||...|     :..:|...||....:.:..|.::.||...:.:.|::.
  Rat   293 ALQKEQVFFKEHPQFRALLEDGKATVPCLAERLTMELISHICKSLPLLENQIKESHQSTSEELQK 357

  Fly   390 W-LILMQEDREALQYCFEELTEMTQRVGRCVLNDQIKTLIPSSVLSFSQPFHPEFPAQIGQYQRS 453
            : ..:.:::.|...:..|::....|.:...|..::|.
  Rat   358 YGADIPEDENEKTLFLIEKINAFNQDITAIVEGEEIV---------------------------- 394

  Fly   454 LCAHLDKLLEDRVLQCLSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFR 518
                       |..:|      |....:.||..|        |               ..::...
  Rat   395 -----------REKEC------RLFTKLRKEFFL--------W---------------SEEIERN 419

  Fly   519 FSLGFTALWHRLEGNLPLHASPFRIQKLQNGHKKCSPLPPLVNGNHWQMLESLVKSKGSLGTVLL 583
            |..|..||:..:          :..:....|.:    ||..||   ::..|::::.:
  Rat   420 FQKGSDALYKEV----------YTFEMQYRGRE----LPGFVN---YKTFENIIRRQ-------- 459

  Fly   584 SAMAIRSFNWPIVLILGGLVGSFYIYEY--AAWTTAAQE---------RSFKSQY--ARLLQQ-- 633
                |::...|.:.:|      ..:.|.  ||:||.:::         |:.||:.  .||.|:
  Rat   460 ----IKTLEEPAMEML------HKVTEIVRAAFTTVSEKNFSEFFNLHRTTKSKLEDIRLEQETE 514

  Fly   634 -----RLRSDVQQTVSGFELQLRQHLATVRNCWEAQSNETLNDLNVRTAELTKQIQSMEVLQLSL 693
                 ||...::|.:...:...|:.|..||. .||:..|..:..:........|..||:.:...|
  Rat   515 AEKAIRLHFQMEQIIYCQDQIYRKALQKVRE-EEAEEEERKHGKSRSAQSPNLQTSSMDEIFQHL 578

  Fly   694 KKFRDK 699
            ..:|.:
  Rat   579 NAYRQE 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	63/276 (23%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	29/148 (20%)
Mx2	NP_599177.2	DLP_1	66..338	CDD:206738	72/315 (23%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	75..82		3/6 (50%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	100..102		0/1 (0%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	176..179		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	245..248		0/2 (0%)
		Dynamin_M	258..544	CDD:395818	65/396 (16%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	277..280		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..568		3/20 (15%)
		GED	569..657	CDD:396682	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900