DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and DNM3

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_016856465.1	Gene:	DNM3 / 26052	HGNCID:	29125	Length:	921	Species:	Homo sapiens

Alignment Length:	746	Identity:	143/746 - (19%)
Similarity:	264/746 - (35%)	Gaps:	228/746 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DRQMLEHLCAFSSRVEAIAKVLSRDRM----KVAFFGRTSNGKSAVINALLHEKILPSAMGHTT- 120
            :|:| |.|....:|::.....|.:..:    ::|..|..|.|||:|:...:....||...|..|
Human     3 NREM-EELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66

  Fly   121 --------------SCFCQVQANGSNETEHVKVEQEDEHMELSALSQLASAHSPGALKPSTLLQV 171
                          :.|...:.....:.:.|::|.|.|...::.:::..|:           :.:
Human    67 RPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISS-----------IPI 120

  Fly   172 NMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVAS 236
            |:......:|  ::.|:|.||:......|...|                     :|.|..:.:..
Human   121 NLRVYSPHVL--NLTLIDLPGITKVPVGDQPPD---------------------IEYQIREMIMQ 162

  Fly   237 KLSRPNLFIL-----NNRWDKASSLEPEMEQKVKDQHMERCVNLL--VDELGVYSTAQEAWERIY 294
            .::|.|..||     |.  |.|:|...::.::|..|.: |.:.::  :|.:...:.|::..|.
Human   163 FITRENCLILAVTPANT--DLANSDALKLAKEVDPQGL-RTIGVITKLDLMDEGTDARDVLEN-- 222

  Fly   295 HVSALEALHIRNGQITNPSGQTQQRYQEFLRFENDFSNCL-----------AVSALKTKFG-PHL 347
                 :.|.:|.|.:     ....|.|:.:..:.|....:           |...:..:.| |||
Human   223 -----KLLPLRRGYV-----GVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPHL 277

  Fly   348 LSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQ-YCFEELTEM 411
               ||:|||              :|.:..::...|...:::..|:.::.:.||.: :..|:.|..
Human   278 ---QKVLNQ--------------QLTNHIRDTLPNFRNKLQGQLLSIEHEVEAYKNFKPEDPTRK 325

  Fly   412 TQRVGRCV-------------LNDQIKTLIPSSVLSFSQPFHPEFPAQIGQYQRSLCAHLDKLLE 463
            |:.:.:.|             ..||:.||..|.....::.||..||.:|
Human   326 TKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEI---------------- 374

  Fly   464 DRVLQCLSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWH 528
                    :.::....::.:||...|..       |:|:    ....|.||:.|...:....:
Human   375 --------VKMEFNEKELRREISYAIKN-------IHGI----RTGLFTPDMAFEAIVKKQIV-- 418

  Fly   529 RLEGNLPLHASPFRIQKLQNGHKKCSP----LPPL------------------------------ 559
            :|:|. .|.:....||:|.|..|||:.    .|.|
Human   419 KLKGP-SLKSVDLVIQELINTVKKCTKKLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQ 482

  Fly   560 ---VNGNH--------WQMLESLVKSK---GSLGTVLLSA--MAIRSFNW----PIVLILGGLVG 604
               :|.||        .|...|.|..|   |:.||.|..:  :.||. .|    .|.::.||..|
Human   483 VSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQGTNLPPSRQIVIRK-GWLTISNIGIMKGGSKG 546

  Fly   605 SFYIY--EYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLATVRNCWEAQSNE 667
            .:::.  |..:|....:..|         |..|..|:||   ||.| |...:.:.:.|.|..::.
Human   547 YWFVLTAESLSWYKDDEIPS---------QTGLLPDLQQ---GFPL-LPHEIYSNQRCKEHLNSY 598

  Fly   668 TLNDLNVRTAELTKQIQSMEVLQLSLKKFRD 698
            .|.::.....:| |:.:...:|.|...|.||
Human   599 FLQEVFPDHLQL-KEKEKKYMLPLDNLKVRD 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	47/272 (17%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	35/138 (25%)
DNM3	XP_016856465.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900