Protein Alignment fzo and DNM3

DIOPT Version :10

• Sequence 1: NP_732840.1
• Gene: fzo / 42745
• FlyBaseID: FBgn0011596
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: XP_016856465.1
• Gene: DNM3 / 26052
• HGNCID: 29125
• Length: 921
• Species: Homo sapiens
• Alignment Length: 746
• Identity: 143/746 - (19%)
• Similarity: 264/746 - (35%)
• Gaps: 228/746 - (30%)

  Fly    61 DRQMLEHLCAFSSRVEAIAKVLSRDRM----KVAFFGRTSNGKSAVINALLHEKILPSAMGHTT- 120
            :|:| |.|....:|::.....|.:..:    ::|..|..|.|||:|:...:....||...|..|
Human     3 NREM-EELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66

  Fly   121 --------------SCFCQVQANGSNETEHVKVEQEDEHMELSALSQLASAHSPGALKPSTLLQV 171
                          :.|...:.....:.:.|::|.|.|...::.:::..|:           :.:
Human    67 RPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISS-----------IPI 120

  Fly   172 NMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVAS 236
            |:......:|  ::.|:|.||:......|...|                     :|.|..:.:..
Human   121 NLRVYSPHVL--NLTLIDLPGITKVPVGDQPPD---------------------IEYQIREMIMQ 162

  Fly   237 KLSRPNLFIL-----NNRWDKASSLEPEMEQKVKDQHMERCVNLL--VDELGVYSTAQEAWERIY 294
            .::|.|..||     |.  |.|:|...::.::|..|.: |.:.::  :|.:...:.|::..|.
Human   163 FITRENCLILAVTPANT--DLANSDALKLAKEVDPQGL-RTIGVITKLDLMDEGTDARDVLEN-- 222

  Fly   295 HVSALEALHIRNGQITNPSGQTQQRYQEFLRFENDFSNCL-----------AVSALKTKFG-PHL 347
                 :.|.:|.|.:     ....|.|:.:..:.|....:           |...:..:.| |||
Human   223 -----KLLPLRRGYV-----GVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPHL 277

  Fly   348 LSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQ-YCFEELTEM 411
               ||:|||              :|.:..::...|...:::..|:.::.:.||.: :..|:.|..
Human   278 ---QKVLNQ--------------QLTNHIRDTLPNFRNKLQGQLLSIEHEVEAYKNFKPEDPTRK 325

  Fly   412 TQRVGRCV-------------LNDQIKTLIPSSVLSFSQPFHPEFPAQIGQYQRSLCAHLDKLLE 463
            |:.:.:.|             ..||:.||..|.....::.||..||.:|
Human   326 TKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEI---------------- 374

  Fly   464 DRVLQCLSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWH 528
                    :.::....::.:||...|..       |:|:    ....|.||:.|...:....:
Human   375 --------VKMEFNEKELRREISYAIKN-------IHGI----RTGLFTPDMAFEAIVKKQIV-- 418

  Fly   529 RLEGNLPLHASPFRIQKLQNGHKKCSP----LPPL------------------------------ 559
            :|:|. .|.:....||:|.|..|||:.    .|.|
Human   419 KLKGP-SLKSVDLVIQELINTVKKCTKKLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQ 482

  Fly   560 ---VNGNH--------WQMLESLVKSK---GSLGTVLLSA--MAIRSFNW----PIVLILGGLVG 604
               :|.||        .|...|.|..|   |:.||.|..:  :.||. .|    .|.::.||..|
Human   483 VSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQGTNLPPSRQIVIRK-GWLTISNIGIMKGGSKG 546

  Fly   605 SFYIY--EYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLATVRNCWEAQSNE 667
            .:::.  |..:|....:..|         |..|..|:||   ||.| |...:.:.:.|.|..::.
Human   547 YWFVLTAESLSWYKDDEIPS---------QTGLLPDLQQ---GFPL-LPHEIYSNQRCKEHLNSY 598

  Fly   668 TLNDLNVRTAELTKQIQSMEVLQLSLKKFRD 698
            .|.::.....:| |:.:...:|.|...|.||
Human   599 FLQEVFPDHLQL-KEKEKKYMLPLDNLKVRD 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	47/272 (17%)
		Fzo_mitofusin	566..716	CDD:461432	37/144 (26%)
DNM3	XP_016856465.1	DYNc	6..245	CDD:197491	51/288 (18%)
		Dynamin_M	215..502	CDD:460033	62/353 (18%)
		PH_dynamin	526..683	CDD:269958	29/118 (25%)
		GED	707..797	CDD:460495
		PHA03247	<806..893	CDD:223021