Protein Alignment fzo and fzo1

DIOPT Version :10

• Sequence 1: NP_732840.1
• Gene: fzo / 42745
• FlyBaseID: FBgn0011596
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_595241.1
• Gene: fzo1 / 2539859
• PomBaseID: SPBC1706.03
• Length: 758
• Species: Schizosaccharomyces pombe
• Alignment Length: 785
• Identity: 159/785 - (20%)
• Similarity: 296/785 - (37%)
• Gaps: 229/785 - (29%)

  Fly     4 SDSGESTSSVSSFISSSSS------SRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETVLLKDR 62
            |.|..:..::...:.|||:      |:|.|  :|...|..::.:.:|
pombe    96 SPSKMNVITIDLSLRSSSTADEKLISQLGE--EAHESLLKVHIEKAN------------------ 140

  Fly    63 QMLEHLCAFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQV- 126
               :||.:..||||..:.       |:...|..:.|||.:.|||:|:.|||......|..||:|
pombe   141 ---KHLFSLFSRVEDTSS-------KILITGDLNAGKSTLCNALVHKDILPEDQQPCTEVFCEVH 195

  Fly   127 --QANGSNETEHV---------------KV-----------EQEDEHMELSALSQLASAHSPGAL 163
              :.|...:..|.               ||           |.|:..|.:..::....||
pombe   196 DAELNDGKDCVHAIPHGLTYSHTDSSTYKVFPIEDLKRLVYETENWSMLIVYVNDGRPAH----- 255

  Fly   164 KPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVER 228
              .:||...:.         |:.|:|.||::..:.....:.:...:.||.:.|:|||:..:....
pombe   256 --ESLLHNGIT---------DIALIDAPGLNTDSMKTTSVFACQEEIDVVVFVVNAENHFTLSAT 309

  Fly   229 QFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYS--TAQEAWE 291
            .|.::.:::.|  ::||:.|::|           .::|:  |||..|:::::...|  |..:|.:
pombe   310 DFLRNASTEKS--HIFIIVNKFD-----------NIRDK--ERCKRLILEQIHTLSPGTFADAKD 359

  Fly   292 RIYHVSALEALHIRNGQITNPSGQTQQRYQEFLRFENDFSNCLAVSALKTKFGPHLLSAQKILNQ 356
            .::.||...|        .:|:.:....|..|.:.||...:.:..:..|:|..|    .::.|:.
pombe   360 LVHFVSCRVA--------RDPNNREDALYSSFFQMENSLRSFILENRSKSKLAP----VRRYLSG 412

  Fly   357 LKSTL--ICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQRVGRCV 419
            |...:  ||.:                  |.::.|:      |...||   :.||:::.:..:..
pombe   413 LVGDILNICEY------------------NIKLIDF------DINHLQ---QRLTDLSPKFRKVK 450

  Fly   420 LNDQI-----KTLIPSSVLSFSQPFHPEFPAQIG-----------------QYQRSLCAHLDKLL 462
            ...|.     ::|:.::|.|.||..|.|....|.                 ||..|:...:.:.|
pombe   451 HEQQFTYQKNESLVEATVQSISQHTHSELEDAIDSLGSFASVKYSGFFFAYQYAISVRDAMQQYL 515

  Fly   463 EDRVLQCLSIPLQR---KILDIEKEIG-------LPIAENSCDWQLIYGLDCQSYMSDFQPDLR- 516
            |:::|:......:|   .:|.|:|::.       ||:...:           |.::...:..|:
pombe   516 EEKLLESEDYARKRTEEAVLCIQKDVKDNFDSAVLPVFHAN-----------QMFIKKHRLQLQK 569

  Fly   517 -FRFSLGFTALWHRLEGNLPLHASPFRIQKLQNGHKKCSPLPPLVNGNHWQMLESLVKSKGSLGT 580
             |||.||   |...::.:|        .::|.......|.: .||.|.......:|....|:||.
pombe   570 HFRFELG---LLDFIDLDL--------TERLGTWSASLSTI-LLVLGKTTPSFTTLGAFTGNLGY 622

  Fly   581 VLLSAMAIRSFNWPIVLILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLR-SDVQQTVS 644
            .:.......|....:|.:||  :.|..::.|..:..   .|:...:.|..:::.|| :|.....|
pombe   623 PIFKYFQNNSLQHLLVPVLG--LASICVFGYVIYDI---PRALPLKVAEKIKKSLRETDFCHNAS 682

  Fly   645 ---GFELQ--LRQHLATVRNC----WEAQSNETL----NDLNV-------------RTAELTKQI 683
               |.|.:  |...|..:|..    |:.| .||:    |||.:             ||.|..|:|
pombe   683 IWIGTESRKVLNIPLNDLRRMFHQQWDKQ-RETISVAENDLRICQKARKFFGEIESRTREAKKKI 746

  Fly   684 QSMEV 688
            ..:::
pombe   747 MMVQL 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	60/277 (22%)
		Fzo_mitofusin	566..716	CDD:461432	33/150 (22%)
fzo1	NP_595241.1	P-loop containing Nucleoside Triphosphate Hydrolases	156..394	CDD:476819	60/276 (22%)