DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and fzo1

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_595241.1	Gene:	fzo1 / 2539859	PomBaseID:	SPBC1706.03	Length:	758	Species:	Schizosaccharomyces pombe

Alignment Length:	785	Identity:	159/785 - (20%)
Similarity:	296/785 - (37%)	Gaps:	229/785 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SDSGESTSSVSSFISSSSS------SRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETVLLKDR 62
            |.|..:..::...:.|||:      |:|.|  :|...|..::.:.:|
pombe    96 SPSKMNVITIDLSLRSSSTADEKLISQLGE--EAHESLLKVHIEKAN------------------ 140

  Fly    63 QMLEHLCAFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQV- 126
               :||.:..||||..:.       |:...|..:.|||.:.|||:|:.|||......|..||:|
pombe   141 ---KHLFSLFSRVEDTSS-------KILITGDLNAGKSTLCNALVHKDILPEDQQPCTEVFCEVH 195

  Fly   127 --QANGSNETEHV---------------KV-----------EQEDEHMELSALSQLASAHSPGAL 163
              :.|...:..|.               ||           |.|:..|.:..::....||
pombe   196 DAELNDGKDCVHAIPHGLTYSHTDSSTYKVFPIEDLKRLVYETENWSMLIVYVNDGRPAH----- 255

  Fly   164 KPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVER 228
              .:||...:.         |:.|:|.||::..:.....:.:...:.||.:.|:|||:..:....
pombe   256 --ESLLHNGIT---------DIALIDAPGLNTDSMKTTSVFACQEEIDVVVFVVNAENHFTLSAT 309

  Fly   229 QFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYS--TAQEAWE 291
            .|.::.:::.|  ::||:.|::|           .::|:  |||..|:::::...|  |..:|.:
pombe   310 DFLRNASTEKS--HIFIIVNKFD-----------NIRDK--ERCKRLILEQIHTLSPGTFADAKD 359

  Fly   292 RIYHVSALEALHIRNGQITNPSGQTQQRYQEFLRFENDFSNCLAVSALKTKFGPHLLSAQKILNQ 356
            .::.||...|        .:|:.:....|..|.:.||...:.:..:..|:|..|    .::.|:.
pombe   360 LVHFVSCRVA--------RDPNNREDALYSSFFQMENSLRSFILENRSKSKLAP----VRRYLSG 412

  Fly   357 LKSTL--ICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQRVGRCV 419
            |...:  ||.:                  |.::.|:      |...||   :.||:::.:..:..
pombe   413 LVGDILNICEY------------------NIKLIDF------DINHLQ---QRLTDLSPKFRKVK 450

  Fly   420 LNDQI-----KTLIPSSVLSFSQPFHPEFPAQIG-----------------QYQRSLCAHLDKLL 462
            ...|.     ::|:.::|.|.||..|.|....|.                 ||..|:...:.:.|
pombe   451 HEQQFTYQKNESLVEATVQSISQHTHSELEDAIDSLGSFASVKYSGFFFAYQYAISVRDAMQQYL 515

  Fly   463 EDRVLQCLSIPLQR---KILDIEKEIG-------LPIAENSCDWQLIYGLDCQSYMSDFQPDLR- 516
            |:::|:......:|   .:|.|:|::.       ||:...:           |.::...:..|:
pombe   516 EEKLLESEDYARKRTEEAVLCIQKDVKDNFDSAVLPVFHAN-----------QMFIKKHRLQLQK 569

  Fly   517 -FRFSLGFTALWHRLEGNLPLHASPFRIQKLQNGHKKCSPLPPLVNGNHWQMLESLVKSKGSLGT 580
             |||.||   |...::.:|        .::|.......|.: .||.|.......:|....|:||.
pombe   570 HFRFELG---LLDFIDLDL--------TERLGTWSASLSTI-LLVLGKTTPSFTTLGAFTGNLGY 622

  Fly   581 VLLSAMAIRSFNWPIVLILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLR-SDVQQTVS 644
            .:.......|....:|.:||  :.|..::.|..:..   .|:...:.|..:::.|| :|.....|
pombe   623 PIFKYFQNNSLQHLLVPVLG--LASICVFGYVIYDI---PRALPLKVAEKIKKSLRETDFCHNAS 682

  Fly   645 ---GFELQ--LRQHLATVRNC----WEAQSNETL----NDLNV-------------RTAELTKQI 683
               |.|.:  |...|..:|..    |:.| .||:    |||.:             ||.|..|:|
pombe   683 IWIGTESRKVLNIPLNDLRRMFHQQWDKQ-RETISVAENDLRICQKARKFFGEIESRTREAKKKI 746

  Fly   684 QSMEV 688
            ..:::
pombe   747 MMVQL 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	60/277 (22%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	32/144 (22%)
fzo1	NP_595241.1	CrfC	95..740	CDD:223771	155/772 (20%)
fzo1	NP_595241.1	P-loop_NTPase	156..394	CDD:304359	60/276 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	42	1.000	Domainoid score	I3669
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I1984
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001757
OrthoInspector	1	1.000	-	-		oto102015
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10465
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.960