DRSC/TRiP Functional Genomics Resources

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Protein Alignment fzo and Mx1

DIOPT Version :9

Sequence 1:NP_732840.1 Gene:fzo / 42745 FlyBaseID:FBgn0011596 Length:718 Species:Drosophila melanogaster
Sequence 2:NP_001257987.1 Gene:Mx1 / 24575 RGDID:3127 Length:652 Species:Rattus norvegicus


Alignment Length:531 Identity:110/531 - (20%)
Similarity:191/531 - (35%) Gaps:129/531 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 QMLEHLCA-FSSRVEAIAKVLSRDRM----------KVAFFGRTSNGKSAVINALLHEKILPSAM 116
            :.:::||: :..:|.....::...|.          .:|..|..|:|||:|:.| |....||...
  Rat    27 ESVDNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEA-LSGVALPRGS 90

  Fly   117 GHTTSC--FCQVQANGSNETEHVKVEQEDEHMELSALS----QLASAHS----PGALKPSTLLQV 171
            |..|.|  ..:::.....|....||..:|..:|:|..|    ::..|.:    .|....|.|:.:
  Rat    91 GIVTRCPLVLKLKQLKQGEKWSGKVIYKDTEIEISHPSLVEREINKAQNLIAGEGLKISSDLISL 155

  Fly   172 NMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVAS 236
            .::.....    |:.|:|.||:...|..|       ..||:       |..:.|:..::.:    
  Rat   156 EVSSPHVP----DLTLIDLPGITRVAVGD-------QPADI-------EHKIKRLITEYIQ---- 198

  Fly   237 KLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNL-----LVDELGVYSTAQEAWERIYHV 296
            |....||.::.:..|.|::...:|.|:| |...:|.:.:     |||        :...:::..|
  Rat   199 KQETINLVVVPSNVDIATTEALKMAQEV-DPQGDRTIGILTKPDLVD--------RGTEDKVVDV 254

  Fly   297 SALEALHIRNG-QITNPSGQTQ-----------QRYQEFLRFENDFS----------NCLAVSAL 339
            ......|::.| .|....||..           |:.|.|.:....|.          .||| ..|
  Rat   255 VRNLVCHLKKGYMIVKCRGQQDIQEQLSLAEALQKEQVFFKEHPQFRVLLEDGKATVPCLA-KRL 318

  Fly   340 KTKFGPHLLSAQKIL-NQL--KSTLICPFIEKVSRLIDENKERRAN-----LNAEIEDWLILMQE 396
            ..:...|:..:..|| ||:  ...:....::|....|.|:..:|.:     :|...:|.|.|:|.
  Rat   319 TMELTSHICKSLPILENQINVNHQIASEELQKYGADIPEDDSKRLSFLMNKINVFNKDILSLVQA 383

  Fly   397 DREALQYCFEELTEMTQ-RVGRCVLNDQI-----KTLIPSSVLSFSQPFHPEFPAQIGQYQRSLC 455
            ..   ...:||....|: |......||.|     |||..|...|..:.|...:..      |.|.
  Rat   384 QE---NISWEESRLFTKLRNEFLAWNDYIEEHFKKTLGSSEKHSQMEKFESHYRG------RELP 439

  Fly   456 AHLD------------KLLEDRVLQCLSIPLQRKILDIEKEIGLPIAENSCDWQLIYG--LDCQS 506
            ..:|            |.||:..|..|     .::..:.|.....::.|:      :|  |:..|
  Rat   440 GFVDYKAFENIIKKEVKALEEPALNML-----HRVTTMVKNAFTKVSSNN------FGDFLNLHS 493

  Fly   507 YMSDFQPDLRF 517
            .......|:||
  Rat   494 TAKSKIEDIRF 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzoNP_732840.1 DLP_2 87..334 CDD:206739 59/293 (20%)
Fzo_mitofusin 572..716 CDD:282633
Mx1NP_001257987.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 110/531 (21%)
DLP_1 59..331 CDD:206738 64/304 (21%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 68..75 3/6 (50%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 93..95 0/1 (0%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 169..172 1/2 (50%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 238..241 0/2 (0%)
Dynamin_M 251..540 CDD:395818 57/275 (21%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 270..273 0/2 (0%)
Bundle signaling element (BSE). /evidence=ECO:0000250 332..357 6/24 (25%)
Middle domain. /evidence=ECO:0000250 357..526 36/168 (21%)
Stalk. /evidence=ECO:0000250 358..622 35/167 (21%)
GED 559..650 CDD:128597
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0699
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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