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Protein Alignment fzo and Mfn1

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_620432.1	Gene:	Mfn1 / 192647	RGDID:	621460	Length:	741	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	259/759 - (34%)
Similarity:	401/759 - (52%)	Gaps:	90/759 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SRLSEFVDAKTELQDIYHDLSNYLSNFLTILEET--------VLLKDRQMLEHLCAFSSRVEAIA 79
            |.|..||.||..:..|:..|..:::.....:|.|        :..:|.  |..:..:.:::..|.
  Rat     6 SPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIATEDD--LVEIQGYRNKLAVIG 68

  Fly    80 KVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQEDE 144
            :||||..||||||||||:|||:||||:|.:|:|||.:||||:||..|:....::. ::..|..||
  Rat    69 EVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKA-YLMTEGSDE 132

  Fly   145 HMELSALSQLASA-HSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCM 208
            ...:..::|||.| |....||...|:.|...|.:|::|..|:||:|:||.|||.:||..:|.:|:
  Rat   133 KKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCL 197

  Fly   209 DADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCV 273
            |||||:||.|:|||:...|:.||..|..:||:||:|||||||| ||:.|||..:.|:.||||||:
  Rat   198 DADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD-ASASEPEYMEDVRRQHMERCL 261

  Fly   274 NLLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITN-PSG------QTQQRYQEFLRFENDFS 331
            :.||:||.|.|.. ||..||:.|||.|.|:.|..:... |.|      ..|.|.|||..||..|.
  Rat   262 HFLVEELKVVSPL-EARNRIFFVSAKEVLNSRMNKAQGMPEGGGALAEGFQARLQEFQNFEQTFE 325

  Fly   332 NCLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNA--EIEDWLILM 394
            .|::.||:||||..|.:.|::||:.:|:.|....:....:.:...:||...::.  .|.:.:.|:
  Rat   326 ECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLL 390

  Fly   395 QEDREALQYCFEELTEMTQRVGR---CVLNDQIKTLIPSSVL--SFSQPFHPEFPAQIGQYQRSL 454
            ..|.:      :::.|:|:.|..   |.:.|:|..|   |||  .|...|||. |:.:..|:..|
  Rat   391 TMDVK------KKIKEVTEEVANKVSCAMTDEICRL---SVLVDEFCSEFHPT-PSVLKVYKSEL 445

  Fly   455 CAHLD----KLLEDRVLQCLS------IPLQRKILDIEKEIGLPIA-ENS------C-DWQLIYG 501
            ..|::    :.|.||   |.|      :..|::|::..|.: ||.. :|.      | .:.|.|.
  Rat   446 NKHIEDGMGRNLADR---CTSEVNASILQSQQEIIENLKPL-LPAGIQNKLHTLIPCKKFDLSYD 506

  Fly   502 LDCQSYMSDFQPDLRFRFSLGFTALWHRLEGN-------LPLHASPFRIQK--LQNGHKKCSPLP 557
            |:|....||||.|:.||||||:::|.||..|:       |.|....|::.:  ........:|..
  Rat   507 LNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPAA 571

  Fly   558 P-----------LVNGNHWQMLESLVKSKGSLGTVLLSAMAIRSFNWPIVLILGGLVGSFYIYEY 611
            |           |:.|     |.||. |:.|:|.:::..:..::..|.::.:...:.|:.|:||.
  Rat   572 PDNAAQEELMITLITG-----LASLT-SRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYER 630

  Fly   612 AAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLAT--VRNCWEAQSNETLNDLNV 674
            ..|||.|:||:||.|:.....::|:..|:.|.:....|::|.:||  .|.|  .|.:.|...|..
  Rat   631 LTWTTRAKERAFKQQFVNYATEKLQMIVKFTSANCSHQVQQEMATTFARLC--QQVDVTQKHLEE 693

  Fly   675 RTAELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYLTKS 718
            ..|.|:|:|..:|.:|.:.|..|:|...|...|.:|.:.:|..|
  Rat   694 EIARLSKEIDQLEKIQNNSKLLRNKAVQLERELENFSKQFLHPS 737

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.