DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzo and Dnm3

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_017454151.1	Gene:	Dnm3 / 171574	RGDID:	727949	Length:	873	Species:	Rattus norvegicus

Alignment Length:	831	Identity:	147/831 - (17%)
Similarity:	284/831 - (34%)	Gaps:	288/831 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DRQMLEHLCAFSSRVEAIAKVLSRDRM----KVAFFGRTSNGKSAVINALLHEKILPSAMGHTT- 120
            :|:| |.|....:|::.....|.:..:    ::|..|..|.|||:|:...:....||...|..|
  Rat     3 NREM-EELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66

  Fly   121 -SCFCQVQANGSNETE--HVKVEQEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCSILD 182
             ....|:..:.:...|  |.|.::..:..|:....:..:....|..|..:.:.:|:......:|
  Rat    67 RPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIEAETDRVTGMNKGISSVPINLRVYSPHVL- 130

  Fly   183 YDVVLMDTPGV----------DVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVASK 237
             ::.|:|.||:          |:..|:.|.:..:....:..||.:...:|
  Rat   131 -NLTLIDLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANT--------------- 179

  Fly   238 LSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLL--VDELGVYSTAQEAWERIYHVSALE 300
                         |.|:|...::.::|..|.: |.:.::  :|.:...:.|::..|.       :
  Rat   180 -------------DLANSDALKLAKEVDPQGL-RTIGVITKLDLMDEGTDARDVLEN-------K 223

  Fly   301 ALHIRNGQITNPSGQTQQRYQEFLRFENDFSNCL-----------AVSALKTKFG-PHLLSAQKI 353
            .|.:|.|.:     ....|.|:.:..:.|....:           |...:..:.| |||   ||:
  Rat   224 LLPLRRGYV-----GVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPHL---QKV 280

  Fly   354 LNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQ-YCFEELTEMTQRVGR 417
            |||              :|.:..::...|...:::..|:.::.:.||.: :..|:.|..|:.:.:
  Rat   281 LNQ--------------QLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALLQ 331

  Fly   418 CV-------------LNDQIKTLIPSSVLSFSQPFHPEFPAQIGQYQRSLCAHLDKLLEDRVLQC 469
            .|             ..||:.||..|.....::.||..||.:|
  Rat   332 MVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEI---------------------- 374

  Fly   470 LSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNL 534
              :.::....::.:||...|..       |:|:    ....|.||:.|...:....:  :|:|.
  Rat   375 --VKMEFNEKELRREISYAIKN-------IHGI----RTGLFTPDMAFEAIVKKQIV--KLKGP- 423

  Fly   535 PLHASPFRIQKLQNGHKKCSP----LPPL---------------------------------VNG 562
            .|.:....:|:|.|..|||:.    .|.|                                 :|.
  Rat   424 SLKSVDLVMQELINTVKKCTKRLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINT 488

  Fly   563 NH--------WQMLESLVKSK---GSLGTVLLSA--MAIRSFNWPIV----LILGGLVGSFYIY- 609
            ||        .|...|.|..|   |:.||.|..:  :.||. .|..|    ::.||..|.:::.
  Rat   489 NHEDFIGFANAQQRSSQVHKKSTIGNQGTNLPPSRQIVIRK-GWLTVSNIGIMKGGSKGYWFVLT 552

  Fly   610 -EYAAWTTAAQERSFK-------------------SQYARLL---QQR----------LRSDVQQ 641
             |..:|....:|:..|                   |::...|   :||          |..|.|:
  Rat   553 AESLSWYKDDEEKEKKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYKDYRSLELACDSQE 617

  Fly   642 TVSGFEL---------------------------------QLRQHLATVRNCWEAQS---NETLN 670
            .|..::.                                 ||.:.:.|:||..::..   |:.:.
  Rat   618 DVDSWKASLLRAGVYPDKSFGSNKTENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIR 682

  Fly   671 DL-----------NVR---TAELTKQIQSME----VLQLSLKKFRDKGQLL 703
            ||           ||:   .:||..|:.|.|    :::.|:::.:.:.::|
  Rat   683 DLIPKTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESVEQAQRRDEML 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	45/266 (17%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	42/229 (18%)
Dnm3	XP_017454151.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900