DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzo and Dnm2

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_006510036.1	Gene:	Dnm2 / 13430	MGIID:	109547	Length:	880	Species:	Mus musculus

Alignment Length:	790	Identity:	147/790 - (18%)
Similarity:	262/790 - (33%)	Gaps:	217/790 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 AFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTT--SCFCQVQANGSN 132
            ||||    |.:....|..::|..|..|.|||:|:...:....||...|..|  ....|:..:.:.
Mouse    19 AFSS----IGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTE 79

  Fly   133 ETE--HVKVEQEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDV 195
            ..|  |.|.::..:..|:....:..:....|..|..:.:.:|:......:|  ::.|:|.||:..
Mouse    80 YAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVL--NLTLIDLPGITK 142

  Fly   196 TAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEM 260
            ....|...|......|:.:..::.||::.                  |.:.....|.|:|...::
Mouse   143 VPVGDQPPDIEYQIKDMILQFISRESSLI------------------LAVTPANMDLANSDALKL 189

  Fly   261 EQKVKDQHMERCVNLL--VDELGVYSTAQEAWERIYHVSALEALHIRNGQITNPSGQTQQRYQEF 323
            .::|..|.: |.:.::  :|.:...:.|::..|.       :.|.:|.|.|     ....|.|:.
Mouse   190 AKEVDPQGL-RTIGVITKLDLMDEGTDARDVLEN-------KLLPLRRGYI-----GVVNRSQKD 241

  Fly   324 LRFENDFSNCLAVSA-----------LKTKFG-PHLLSAQKILNQLKSTLICPFIEKVSRLIDEN 376
            :..:.|....||...           :..:.| |||   ||.|||..:..|   .|.:..|..:.
Mouse   242 IEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHL---QKTLNQQLTNHI---RESLPTLRSKL 300

  Fly   377 KERRANLNAEIEDWLILMQED--REALQYCFEELTEMTQRVGRCV------LNDQIKTLIPSSVL 433
            :.:..:|..|:|::.....:|  |:.     :.|.:|.|:.|...      ..||:.||..|...
Mouse   301 QSQLLSLEKEVEEYKNFRPDDPTRKT-----KALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA 360

  Fly   434 SFSQPFHPEFPAQIGQYQ-------RSLCAHLDKL------------------------LEDRVL 467
            ..::.||..||.::.:.:       |.:...:..:                        |::..|
Mouse   361 RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCL 425

  Fly   468 QCLSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEG 532
            :|:.:.:|..|..:.:                    |.|.:|.: |.||.......|......||
Mouse   426 KCVDLVIQELISTVRQ--------------------CTSKLSSY-PRLREETERIVTTYIREREG 469

  Fly   533 NLP---LHASPFRIQKLQNGHK------KCSPLPPLVNGNHWQMLESLVKSKG--SLGTVLLSAM 586
            ...   |.........:...|:      .|.....||.|.. |....|.|.:.  :.|.:|:...
Mouse   470 RTKDQILLLIDIEQSYINTNHEDFIGFANCFYTEELVTGAQ-QRSTQLNKKRAIPNQGEILVIRR 533

  Fly   587 AIRSFNWPIVLILGGLVGSFYIY--EYAAWTTAAQERSFK------------------------- 624
            ...:.| .|.|:.||....:::.  |..:|....:|:..|
Mouse   534 GWLTIN-NISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFA 597

  Fly   625 -------SQYARLLQQRLRSDVQQTVSGFEL-----------------------------QLRQH 653
                   :.|..|.|..|..|.|:.|..::.                             ||.:.
Mouse   598 IFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQ 662

  Fly   654 LATVRN---CWEAQSNETLNDLNVRT-----AELTKQIQSMEVLQLSLKKFRDKGQLL------A 704
            :.|:||   .:.|..|:::.||..:|     ...||.....|:|.. |....|:..|:      |
Mouse   663 VETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAY-LYSSADQSSLMEESAEQA 726

  Fly   705 SRLGDFQETY 714
            .|..|....|
Mouse   727 QRRDDMLRMY 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	46/252 (18%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	40/222 (18%)
Dnm2	XP_006510036.1	DYNc	6..245	CDD:197491	51/262 (19%)
		Dynamin_M	216..498	CDD:366427	58/325 (18%)
		PH_dynamin	530..639	CDD:269958	16/109 (15%)
		GED	660..749	CDD:366984	19/78 (24%)
		PHA03247	<747..878	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900