DRSC/TRiP Functional Genomics Resources

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Protein Alignment fzo and Dnm1l

DIOPT Version :10

Sequence 1:NP_732840.1 Gene:fzo / 42745 FlyBaseID:FBgn0011596 Length:718 Species:Drosophila melanogaster
Sequence 2:NP_001424611.1 Gene:Dnm1l / 114114 RGDID:620416 Length:761 Species:Rattus norvegicus


Alignment Length:560 Identity:87/560 - (15%)
Similarity:177/560 - (31%) Gaps:211/560 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 LEHLCAFSSRVEAIAKVLSRDRM---KVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQV 126
            :|.|....::::.:...:..|.:   ::...|..|:|||:|:.:|:...:||...|..|.....:
  Rat     1 MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLIL 65

  Fly   127 QANGSNETEHVKVEQEDEHMELSALSQLASAHSPGALKPSTLLQVNM----------AKNRCSIL 181
            |.        |.|..||:.......:....:.:|...|.|..|...:          .||:. ..
  Rat    66 QL--------VHVSPEDKRKTTGEENGKFQSWNPATWKNSRHLSKGVEAEEWGKFLHTKNKL-YT 121

  Fly   182 DYD------------------------------------VVLMDTPGV----------DVTAQLD 200
            |:|                                    :.|:|.||:          |:..|:.
  Rat   122 DFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIR 186

  Fly   201 DCLDSYCMDADVFILVLNAEST------VSRVERQFFKD------VASKL--------------- 238
            :.:..:..:.:..||.:.|.:|      ..::.|:...|      |.:||               
  Rat   187 ELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMG 251

  Fly   239 -------------SRPNLFILNNRWDKASSLE----------PEMEQKVKDQHMERCVNLLVDEL 280
                         :|..|.| ||:.....|:.          |.:..:...:::.|.:|.|:   
  Rat   252 RVIPVKLGIIGVVNRSQLDI-NNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLL--- 312

  Fly   281 GVYSTAQEAWERIYHV--------SALEALHIRNGQITNPSGQ-----TQQRYQEFLRFENDFSN 332
                        ::|:        :.:..|..:...:.|..|:     :....|...:|..::.|
  Rat   313 ------------MHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCN 365

  Fly   333 CLAVSA--LKTK---------------FGPHLLSAQKI--LNQL------------KSTLICP-- 364
            .:..:|  ::|.               ||..|.|...:  ||.:            :..|..|  
  Rat   366 TIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEV 430

  Fly   365 ----FIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYC----------FEELTEMTQRV 415
                .:::..:.::|...|...|         :.:|.:..:|:|          |.:|.:....|
  Rat   431 SFELLVKRQIKRLEEPSLRCVEL---------VHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEV 486

  Fly   416 GRCVL-------NDQIKTLIPSSVLSFSQPFHPEFPAQIG 448
            ..|:|       |:.:..|: :..|::....||:|....|
  Rat   487 VTCLLRKRLPVTNEMVHNLV-AIELAYINTKHPDFADACG 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzoNP_732840.1 DLP_2 87..334 CDD:206739 56/368 (15%)
Fzo_mitofusin 566..716 CDD:461432
Dnm1lNP_001424611.1 G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 32..39 3/6 (50%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 58..60 0/1 (0%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 165..168 1/2 (50%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 234..237 1/2 (50%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 264..267 0/2 (0%)
Middle domain. /evidence=ECO:0000250|UniProtKB:O00429 363..508 24/154 (16%)
Interaction with GSK3B. /evidence=ECO:0000250|UniProtKB:O00429 467..710 12/60 (20%)
B domain. /evidence=ECO:0000250|UniProtKB:O00429 521..588 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..616
Important for homodimerization. /evidence=ECO:0000250|UniProtKB:O00429 679..693
Blue background indicates that the domain is not in the aligned region.

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