DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzo and Dnm3

DIOPT Version :9

Sequence 1:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_006496664.1	Gene:	Dnm3 / 103967	MGIID:	1341299	Length:	873	Species:	Mus musculus

Alignment Length:	822	Identity:	149/822 - (18%)
Similarity:	283/822 - (34%)	Gaps:	266/822 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DRQMLEHLCAFSSRVEAIAKVLSRDRM----KVAFFGRTSNGKSAVINALLHEKILPSAMGHTT- 120
            :|:| |.|....:|::.....|.:..:    ::|..|..|.|||:|:...:....||...|..|
Mouse     3 NREM-EELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66

  Fly   121 -SCFCQVQANGSNETE--HVKVEQEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCSILD 182
             ....|:..:.:...|  |.|.::..:..|:....:..:....|..|..:.:.:|:......:|
Mouse    67 RPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIEAETDRVTGMNKGISSIPINLRVYSPHVL- 130

  Fly   183 YDVVLMDTPGV----------DVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVASK 237
             ::.|:|.||:          |:..|:.|.:..:....:..||.:...:|
Mouse   131 -NLTLIDLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANT--------------- 179

  Fly   238 LSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLL--VDELGVYSTAQEAWERIYHVSALE 300
                         |.|:|...::.::|..|.: |.:.::  :|.:...:.|::..|.       :
Mouse   180 -------------DLANSDALKLAKEVDPQGL-RTIGVITKLDLMDEGTDARDVLEN-------K 223

  Fly   301 ALHIRNGQITNPSGQTQQRYQEFLRFENDFSNCL-----------AVSALKTKFG-PHLLSAQKI 353
            .|.:|.|.:     ....|.|:.:..:.|....:           |...:..:.| |||   ||:
Mouse   224 LLPLRRGYV-----GVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPHL---QKV 280

  Fly   354 LNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQ-YCFEELTEMTQRVGR 417
            |||              :|.:..::...|...:::..|:.::.:.||.: :..|:.|..|:.:.:
Mouse   281 LNQ--------------QLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALLQ 331

  Fly   418 CV-------------LNDQIKTLIPSSVLSFSQPFHPEFPAQIGQYQRSLCAHLDKLLEDRVLQC 469
            .|             ..||:.||..|.....::.||..||.:|
Mouse   332 MVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEI---------------------- 374

  Fly   470 LSIPLQRKILDIEKEIGLPIAENSCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNL 534
              :.::....::.:||...|..       |:|:    ....|.||:.|...:....:  :|:|.
Mouse   375 --VKMEFNEKELRREISYAIKN-------IHGI----RTGLFTPDMAFEAIVKKQIV--KLKGP- 423

  Fly   535 PLHASPFRIQKLQNGHKKCSP----LPPL---------------------------------VNG 562
            .|.:....:|:|.|..|||:.    .|.|                                 :|.
Mouse   424 SLKSVDLVMQELINTVKKCTKRLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINT 488

  Fly   563 NH--------WQMLESLVKSK---GSLGTVLLSA--MAIRSFNWPIV----LILGGLVGSFYIY- 609
            ||        .|...|.|..|   |:.||.|..:  :.||. .|..|    ::.||..|.:::.
Mouse   489 NHEDFIGFANAQQRSSQVHKKSTIGNQGTNLPPSRQIVIRK-GWLTVSNIGIMKGGSKGYWFVLT 552

  Fly   610 -EYAAWTTAAQERSFK-------------------SQYARLL---QQR----------LRSDVQQ 641
             |..:|....:|:..|                   |::...|   :||          |..|.|:
Mouse   553 AESLSWYKDDEEKEKKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYKDYRFLELACDSQE 617

  Fly   642 TVSGFELQLRQHLATVRNCWEAQSNETLNDLNVRT------AELTKQIQSME------------- 687
            .|..::..|.:  |.|.......||:|.||.|.:.      .:|.:|::::.
Mouse   618 DVDSWKASLLR--AGVYPDKSVGSNKTENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKC 680

  Fly   688 --------VLQLSLKKFRD--KGQLLASRL-GDFQETYLTKS 718
                    ::.|.:...:|  ..:|||... .:.|.|.:.:|
Mouse   681 IRDLIPKTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEES 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	45/266 (17%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633	43/216 (20%)
Dnm3	XP_006496664.1	DYNc	6..245	CDD:197491	49/282 (17%)
		Dynamin_M	216..502	CDD:366427	61/352 (17%)
		PH_dynamin	526..635	CDD:269958	22/111 (20%)
		GED	660..749	CDD:366984	9/63 (14%)
		MISS	<757..845	CDD:318115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900