Protein Alignment fzo and mfn1a

DIOPT Version :10

• Sequence 1: NP_732840.1
• Gene: fzo / 42745
• FlyBaseID: FBgn0011596
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: XP_073778770.1
• Gene: mfn1a / 100329462
• ZFINID: ZDB-GENE-121101-4
• Length: 732
• Species: Danio rerio
• Alignment Length: 752
• Identity: 246/752 - (32%)
• Similarity: 378/752 - (50%)
• Gaps: 89/752 - (11%)

  Fly    23 SRLSEFVDAKTELQDIYHDLSNYLSNFLTILEET-------VLLKDRQMLEHLCAFSSRVEAIAK 80
            |.|..||.||..:..::|.|..::......:|:|       .:.::.|.|:....| .::..|..
Zfish     7 SPLQHFVVAKKTISALFHQLLEFVKEGSDFVEDTWRSEDLDNVAEEDQCLQIQTCF-RKLTVIKD 70

  Fly    81 VLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQEDEH 145
            ||.|..||||||||||||||.:|||:|.|::|||.:||||:||..|:.. ..|..::..|..:|.
Zfish    71 VLDRRHMKVAFFGRTSNGKSTIINAMLRERVLPSGIGHTTNCFLSVEGT-DGEQAYLTTEDSEER 134

  Fly   146 MELSALSQLASA-HSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMD 209
            ..:..::.||.| |.........|::|...|.:|.:|..|:||||:||:|||::||..:|.:|:|
Zfish   135 KGIETVNHLAHALHMNRNQDSGCLVRVFWPKTKCVLLRDDLVLMDSPGIDVTSELDSWIDKFCLD 199

  Fly   210 ADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVN 274
            ||||:||.|:|||:...|:.||..|..::|:||:|||||||| ||.||||..:.|:.|||:|||:
Zfish   200 ADVFVLVANSESTIMNTEKHFFHKVNERISKPNIFILNNRWD-ASVLEPEYLEDVRKQHMDRCVS 263

  Fly   275 LLVDELGVYSTAQEAWERIYHVSALEAL--HIRNGQITNPSGQT-----QQRYQEFLRFENDFSN 332
            .|||||.|.. ..:|.:||:.|||.|.|  .|...|....:|..     |:|..||..||..|..
Zfish   264 FLVDELKVVD-LNKAPDRIFFVSAKEVLSARIHRAQGMPETGGALAEGFQERLMEFQSFERTFEE 327

  Fly   333 CLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQED 397
            .::.||:||||..|.:.|.:|            ||.|..::|.       :|....:..:...||
Zfish   328 FISQSAVKTKFEQHTIRAWQI------------IESVKAIMDA-------INISSAEKKVFSLED 373

  Fly   398 REA----LQYCFEELTEMTQRVGR--CVLNDQIKTLIPS---------SVL--SFSQPFHPEFPA 445
            |||    |::...:|..:|:.:..  .|::|::...:.|         |||  .|...|.|. |.
Zfish   374 REALMDRLEFVRNQLNFITEDIKDKIKVVSDEVAAKVSSALEEEMRCLSVLVDEFCSEFIPA-PN 437

  Fly   446 QIGQYQRSLCAHL-DKLLEDRVLQCLS------IPLQRKILDIEKEIGLPIAE-----NSCDWQL 498
            .:..|:..|.::: ::::::..|:|.|      :..||.|:|..:.:..|.|.     .|..:.:
Zfish   438 ALALYKTKLVSYVEERMVKNLELRCSSSINGCVLSSQRDIMDTLRPLLPPAARAQLHLPSRRFTM 502

  Fly   499 IYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLHASPFRIQKLQNGHKKCSPLPPLVNGN 563
            .|.|:..|..:||..|:.|.||||.|:|.:|..|  |.:|.. .:..|:...|..|......:..
Zfish   503 TYDLNLTSLGADFTEDIDFHFSLGLTSLVNRFLG--PANAKQ-ALSLLEQKLKLTSSSAHTGSRG 564

  Fly   564 HWQMLESL------VKSKGSLGTV------LLSAMAIRSFNWPIVLILGGLVGSFYIYEYAAWTT 616
            |..:..|:      :.|:.||..|      |...:..|:..|.::::...|....|:||...||.
Zfish   565 HEDLALSMASGLLSLTSRASLAPVGQKRLALYKLLVWRAVGWRVIVLSVSLYSFLYLYERLTWTN 629

  Fly   617 AAQERSFKSQYARLLQQRLRSDVQQTVSGFE-LQLRQHLATV--RNCWEAQSNETLNDLNVRTAE 678
            :::||:.|.||.....|||:: |...:||.. .|::|.:..|  |.|.:...:|.  :|......
Zfish   630 SSKERALKQQYVDHTTQRLQA-VAHIISGDSGQQVQQEMVAVFARMCQQVDKSEM--ELETEIRR 691

  Fly   679 LTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYL 715
            |:.:||.:|.:|...|..|.|...|.|:|..|...||
Zfish   692 LSARIQRLESVQRRSKTLRHKATDLESQLERFSAQYL 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	118/254 (46%)
		Fzo_mitofusin	566..716	CDD:461432	46/165 (28%)
mfn1a	XP_073778770.1	None