DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnc and NFE2L3

DIOPT Version :9

Sequence 1:	NP_001262864.1	Gene:	cnc / 42743	FlyBaseID:	FBgn0262975	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_004280.5	Gene:	NFE2L3 / 9603	HGNCID:	7783	Length:	694	Species:	Homo sapiens

Alignment Length:	720	Identity:	186/720 - (25%)
Similarity:	265/720 - (36%)	Gaps:	161/720 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   647 VGSGTGSAFQRQP--AAGGF---HHGHHQGRMPRLNRSVSME-----RLQDFATYFSP------- 694
            :|....||:...|  |:||:   .|.|.:||  .|:.:...|     .::.....|.|
Human    49 LGGPASSAYALSPFSASGGWGRAGHLHPKGR--ELDPAAPPEGQLLREVRALGVPFVPRTSVDAW 111

  Fly   695 -IPSMVGGVSDMSPYPHHYPGYSYQASPSNGAPGTP---GQHGQYGSGANATLQPPPPPPPPHHA 755
             :.|:..|.:|.:   |...|.:  |:.|.|..|..   |.....|.|.:.......|.......
Human   112 LVHSVAAGSADEA---HGLLGAA--AASSTGGAGASVDGGSQAVQGGGGDPRAARSGPLDAGEEE 171

  Fly   756 AMLHHPNAALGDICPTGQPHYGHNLGSAVTSSMHLTNSSHEADGAAAAAAAYKVEHDLMYYGN-- 818
            .....|.|.:.|            .|...:....:....|||           |:|...:..|
Human   172 KAPAEPTAQVPD------------AGGCASEENGVLREKHEA-----------VDHSSQHEENEE 213

  Fly   819 -----TSSDINQTDGFINSIF---------------------TDEDLHLMDMNESFCRMVDNSTS 857
                 ..:.:.|.|...|.|.                     ||....|.|:.:......:||..
Human   214 RVSAQKENSLQQNDDDENKIAEKPDWEAEKTTESRNERHLNGTDTSFSLEDLFQLLSSQPENSLE 278

  Fly   858 NNSSVLG-LPSSGHVSNGSGSSAQLGAGNPHGNQANGASGGVGSMSGSAVGAGATGMTADLLASG 921
            ..|  || :|..|.:|:|..|||..     |.|.:...|..|....            |.||...
Human   279 GIS--LGDIPLPGSISDGMNSSAHY-----HVNFSQAISQDVNLHE------------AILLCPN 324

  Fly   922 GAGAQGGADRLDASSDSAVSSMGSERVPSLS-DGEWGEGSDSAQDYHQGKYGGP---YDFSYN-- 980
            ....:....|...|.:..:........|..: .|....|..|..|.|.......   ||...|
Human   325 NTFRRDPTARTSQSQEPFLQLNSHTTNPEQTLPGTNLTGFLSPVDNHMRNLTSQDLLYDLDINIF 389

  Fly   981 ---NNSRLSTATRQPPVAQKKHQLYGKRD---------PHKQTPSALPPTAPPAAATAVQSQSIK 1033
               |...|:|.....|:  ...||:.:.|         .|..|          :...:..|.|:.
Human   390 DEINLMSLATEDNFDPI--DVSQLFDEPDSDSGLSLDSSHNNT----------SVIKSNSSHSVC 442

  Fly  1034 YEYDAGYASSGMASGGISEPGAMG---PALSKDYHHHQPYGMGASGSAFSGDYTVRPSPRTSQDL 1095
            .|...||.:...:|......||:|   |..||..|..|      |.|.|.||.|.:.
Human   443 DEGAIGYCTDHESSSHHDLEGAVGGYYPEPSKLCHLDQ------SDSDFHGDLTFQH-------- 493

  Fly  1096 VQLNHTYSLPQGSGSLPRPQARDKKPLVATKTASKGASAGNSSSVGGNSSNLEEEHLTRDEKRAR 1160
            |..||||.|               :|.....|:......|.|..:........:.:|:|||:||:
Human   494 VFHNHTYHL---------------QPTAPESTSEPFPWPGKSQKIRSRYLEDTDRNLSRDEQRAK 543

  Fly  1161 SLNIPISVPDIINLPMDEFNERLSKYDLSENQLSLIRDIRRRGKNKVAAQNCRKRKLDQILTLED 1225
            :|:||.||.:|:.:|:|.||..||:|.|::.|:|||||||||||||||||||||||||.||.|||
Human   544 ALHIPFSVDEIVGMPVDSFNSMLSRYYLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLED 608

  Fly  1226 EVNAVVKRKTQLNQDRDHLESERKRISNKFAMLHRHVFQYLRDPEGNPCSPADYSLQQAADGSVY 1290
            :|..:..:|..|.:::.........:..|...|:..:|..|||.:|.|.:|..|:||...|||:.
Human   609 DVCNLQAKKETLKREQAQCNKAINIMKQKLHDLYHDIFSRLRDDQGRPVNPNHYALQCTHDGSIL 673

  Fly  1291 LLPRE 1295
            ::|:|
Human   674 IVPKE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnc	NP_001262864.1	bZIP_CNC	1192..1259	CDD:269846	35/66 (53%)
cnc	NP_001262864.1	coiled coil	1193..1255	CDD:269846	33/61 (54%)
NFE2L3	NP_004280.5	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..256		21/145 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..357		3/26 (12%)
		bZIP_NFE2-like	575..642	CDD:269868	35/66 (53%)
		coiled coil	576..638	CDD:269868	33/61 (54%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	580..599		18/18 (100%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	606..620		5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7244
eggNOG	1	0.900	-	-		E1_KOG3863
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1095280at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41414
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920