DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cnc and bach2a

DIOPT Version :9

Sequence 1:	NP_001262864.1	Gene:	cnc / 42743	FlyBaseID:	FBgn0262975	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_685315.5	Gene:	bach2a / 557210	ZFINID:	ZDB-GENE-120525-2	Length:	761	Species:	Danio rerio

Alignment Length:	653	Identity:	147/653 - (22%)
Similarity:	233/653 - (35%)	Gaps:	142/653 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 PPHHAAML--HHPN------AALGDICPTGQPHYGHNLGSAVTSSMHLTNSSHEADGAAAAAAAY 807
            ||.:..:|  ||.|      ..|.|..|   |.:|..|.|. |..|.:..|.............|
Zfish   142 PPSNQTLLQNHHNNKTEDAKVQLRDSKP---PLFGSRLHSE-TEQMKMHQSDQPQPFDLPRYPKY 202

  Fly   808 KVEHDLMYYGNTS----SDINQTDGFINSIFTDEDLHLMDMNESFCRMVDNSTSNNSSVLGLPSS 868
            :..|.:....|||    |..:...|.:....|..:...:|:::.....|:...|....:..|..:
Zfish   203 RKYHQVHAKHNTSTSSHSSTSSLQGSLQDTVTSSNARGLDLSKVKAEPVNGEVSVPLDLSELEQN 267

  Fly   869 GHVSNGSGSSAQLG----------AGNPHGNQANGASG-GVGSMSGSAVGAGATGMTADLLASGG 922
            |.|   .|...::.          :..|:...|:..|. .:.|:....|.:....::.||..|
Zfish   268 GPV---RGKVIEMDIEMEFDGRQLSSTPNEFPASKRSPVCLRSLVKKEVSSSDHCLSTDLQLS-- 327

  Fly   923 AGAQGGADRLDASSDSAVSSMGSERVPSLSDGEWGEGSDSAQDYHQGKYGG------PYDFSYNN 981
                           |..|.:..::|.::.:    :..|..:|| |...||      |...|..:
Zfish   328 ---------------SRTSPLREQQVVTVQE----QQVDFQKDY-QAFIGGLSSKKLPDGVSLKS 372

  Fly   982 NSRLSTATRQPPVAQ--KKHQLYGKRDPHKQTPSALPP------TAPPAAATAVQSQSIKYEYDA 1038
            .| |.....|.|..:  :|..::..|.|:...|:...|      ...|....|..|||.......
Zfish   373 LS-LERICSQDPEQENDRKSVIFSSRGPYHLAPTHSYPDESCLGQETPEDLWAGSSQSFPCTQTL 436

  Fly  1039 GYASSGMASGGISEPGAMGPALSKDYHHHQ----PYGMGASGSAFSGDYTVRPSPRTSQDLVQLN 1099
            ...||           :..|:|  .|..|.    |..:.....:...|..||.|...|      :
Zfish   437 SPTSS-----------SQDPSL--PYRRHPKSSCPVPIKMCSRSTRADSHVRTSSSCS------S 482

  Fly  1100 HTYSLPQGSGSLPR--PQ------------------ARDKKPLVATKTASKGASAGNSSSVGGNS 1144
            ::|: ..|||..|.  ||                  .|:.......|...:.:...|||...|:.
Zfish   483 YSYA-EDGSGGSPSSLPQFELSTSPCSTMARCLALEHREHSTSGPPKIKCEKSYDTNSSDESGSF 546

  Fly  1145 SNLEEEHLTRDEKRARSLNIPISVPDIINLPMDEFNERLSKYDLSENQLSLIRDIRRRGKNKVAA 1209
            |:.:.|.....| |.:.:.:|.||..|..||.::|...:..:.||.:||..|.|:|||.||::||
Zfish   547 SDGDSESFATKE-RTQEVKLPFSVDQITELPRNDFQLMIKMHKLSSDQLDFIHDMRRRSKNRIAA 610

  Fly  1210 QNCRKRKLDQILTLEDEVNAVVKRKTQLNQDRDHLESERKRISNKFAMLHRHVFQYLRDPEGNPC 1274
            |.|||||||.|..||.|::.:|..:.:|..:|..|::....:...|:.|.:.|   .|:.:..|.
Zfish   611 QRCRKRKLDCIQNLEREIHKLVCERQKLLTERSQLKTCMGELWENFSFLSKEV---CREEQRTPR 672

  Fly  1275 SPADYSLQQAADGS---VYLLPREKS----------------------EGNNTATAASNAVSSAS 1314
            |..:........|:   :.|:|..|.                      ...|||:..|:|  |.:
Zfish   673 SQYNPHTDPVLSGTELQISLIPNSKDISDCQTTQPPHLHRRADRDTEPSQENTASIRSDA--SQT 735

  Fly  1315 GGS 1317
            |.|
Zfish   736 GSS 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnc	NP_001262864.1	bZIP_CNC	1192..1259	CDD:269846	28/66 (42%)
cnc	NP_001262864.1	coiled coil	1193..1255	CDD:269846	26/61 (43%)
bach2a	XP_685315.5	BTB	27..129	CDD:279045
		BTB	38..130	CDD:197585
		bZIP	590..660	CDD:304365	29/69 (42%)
		coiled coil	599..650	CDD:269834	24/50 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3863
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002254
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900