DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnc and NFE2L1

DIOPT Version :9

Sequence 1:	NP_001262864.1	Gene:	cnc / 42743	FlyBaseID:	FBgn0262975	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_003195.1	Gene:	NFE2L1 / 4779	HGNCID:	7781	Length:	772	Species:	Homo sapiens

Alignment Length:	1161	Identity:	248/1161 - (21%)
Similarity:	362/1161 - (31%)	Gaps:	510/1161 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 LHPTS-ELDTFLTPHALQDQRSIWEQNLADLYDYNDLSLQTSPYANLPLKDGQPQPSNSSHLDLS 241
            :||.| :||.:.|...|..|....::......:.|...:...|
Human    67 IHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNAWLVHRDP---------------------- 109

  Fly   242 LAALLHGFTGGSGAPLSTAALNDSTPHPRNLGSVTNNSAG-RSDDGEESLYLGRLFGEDEDEDYE 305
                 .|...|| .|.|..||..|:    .|..||....| |..:.|:.      ||||.::
Human   110 -----EGSVSGS-QPNSGLALESSS----GLQDVTGPDNGVRESETEQG------FGEDLED--- 155

  Fly   306 GELIGGVANACEVEGLTTDEPFGSNCFANEVEIGDDEEESEIAEVLYKQDVDLGFSLDQEAIINA 370
               :|.||.  .|.|..|                  :|:.::.::|::||:|||...:   :.:.
Human   156 ---LGAVAP--PVSGDLT------------------KEDIDLIDILWRQDIDLGAGRE---VFDY 194

  Fly   371 SYASGNSAATNVKSKPEDETKSSDPSISESSGFKDTDVNAENEASAASVDDIEKLKALEELQQDK 435
            |:          :.|.:|..|.     ....|.:||......||.|.::
Human   195 SH----------RQKEQDVEKE-----LRDGGEQDTWAGEGAEALARNL---------------- 228

  Fly   436 DKNNENQLEDITNEWNGIPFTIDNETGEYIRLPLDELLNDVLKLSEFPLQDDLSNDPVAST---- 496
                                .:|.||||                 .||.|.....|..|.:
Human   229 --------------------LVDGETGE-----------------SFPAQVPSGEDQTALSLEEC 256

  Fly   497 ---SQAAAAFNENQAQRIVSETGEDLLSGEGISSKQNRNEAKNKDNDPEKADGDSFSVSDFEELQ 558
               .:|...|.||      :|...|:.|         ..||...:::|             ..||
Human   257 LRLLEATCPFGEN------AEFPADISS---------ITEAVPSESEP-------------PALQ 293

  Fly   559 NSVGSPL-------FDLDE--------------DAKKELDEMLQSAVPSYHHPHPHHGHPHAHPH 602
            |::.|||       |||::              :......|:|.||.|         |.|.:..:
Human   294 NNLLSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVNTSASEILYSAPP---------GDPLSTNY 349

  Fly   603 S-------HHHASMHHAHAHHAAAAAAAHQRAVQQANYGGGVGVGVGVGVGVGSGTGSAFQRQPA 660
            |       :.:.|:|                   ||:.||
Human   350 SLAPNTPINQNVSLH-------------------QASLGG------------------------- 370

  Fly   661 AGGFHHGHHQGRMPRLNRSVSMERLQDFATYFSPIPSM-VGGVSDMSPYPHHYPGYSYQASPSNG 724
                                   ..|||..:...:.|: |...|.:.|..   |..|...:.:.|
Human   371 -----------------------CSQDFLLFSPEVESLPVASSSTLLPLA---PSNSTSLNSTFG 409

  Fly   725 APGTPGQH--GQYGSGANATLQPPPPPPPPHHAAMLHHPNAALGDICPTGQPHYGHNLGSAVTSS 787
            :....|..  .|....||.|..|..|.|              ||.:           |..|:...
Human   410 STNLTGLFFPPQLNGTANDTAGPELPDP--------------LGGL-----------LDEAMLDE 449

  Fly   788 MHLTNSSHEADGAAAAAAAYKVEHDLMYYGNTSSDINQTDGFINSIFTDEDLHLMDMNESFCRMV 852
            :.|.:.:.|.......|:..:.|.|                      :|..|.|
Human   450 ISLMDLAIEEGFNPVQASQLEEEFD----------------------SDSGLSL----------- 481

  Fly   853 DNSTSNNSSVLGLPSSGHVSNGSGSSAQLGAGNPHGNQANGASGGVGSMSGSAVGAGATGMTADL 917
            |:|.|        |||...|.||.||:        .:.::.:|....|.|.|....||.|.::|
Human   482 DSSHS--------PSSLSSSEGSSSSS--------SSSSSSSSSASSSASSSFSEEGAVGYSSD- 529

  Fly   918 LASGGAGAQGGADRLDASSDSAVSSMGSERVPSLSDGEWGEGSDSAQDYHQGKYGGPYDFSYNNN 982
                       ::.||                 |.:.|...|       :|.:|......||.:.
Human   530 -----------SETLD-----------------LEEAEGAVG-------YQPEYSKFCRMSYQDP 559

  Fly   983 SRLSTATRQPPVAQKKHQLYGKRDPHKQTPSALPPTAPPAAATAVQSQSIKYEYDAGYASSGMAS 1047
            ::|                           |.||
Human   560 AQL---------------------------SCLP------------------------------- 566

  Fly  1048 GGISEPGAMGPALSKDYHHHQPYGMGASGSAFSGDYTVRPSPRTSQDLVQLNHTYSLPQGSGSLP 1112
                            |..|                            |..||||::
Human   567 ----------------YLEH----------------------------VGHNHTYNM-------- 579

  Fly  1113 RPQARDKKPLVATKTASKGASAGNSSSVGGNSSNLEEEHLTRDEKRARSLNIPISVPDIINLPMD 1177
            .|.|.|...|.......||:..        ..::..::.::|||.|||::.||.:...|||||::
Human   580 APSALDSADLPPPSALKKGSKE--------KQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVE 636

  Fly  1178 EFNERLSKYDLSENQLSLIRDIRRRGKNKVAAQNCRKRKLDQILTLEDEVNAVVKRKTQLNQDRD 1242
            ||||.||||.|||.|||||||||||||||:|||||||||||.||.||.:|..:.:.|.:|.:::.
Human   637 EFNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKV 701

  Fly  1243 HLESERKRISNKFAMLHRHVFQYLRDPEGNPCSPADYSLQQAADGSVYLLPREKSE 1298
            ......:::..|...|::.||..|||..|.|.||:.|:||.|.||||.|:||..::
Human   702 EFLRSLRQMKQKVQSLYQEVFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRTMAD 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnc	NP_001262864.1	bZIP_CNC	1192..1259	CDD:269846	34/66 (52%)
cnc	NP_001262864.1	coiled coil	1193..1255	CDD:269846	32/61 (52%)
NFE2L1	NP_003195.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..148		15/71 (21%)
		Cholesterol recognition/amino acid consensus (CRAC) region. /evidence=ECO:0000250\|UniProtKB:Q61985	191..199		1/17 (6%)
		CPD. /evidence=ECO:0000250\|UniProtKB:Q61985	379..383		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..532		24/122 (20%)
		Destruction motif. /evidence=ECO:0000250\|UniProtKB:Q61985	476..480		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..613		5/38 (13%)
		bZIP_NFE2-like	651..718	CDD:269868	34/66 (52%)
		coiled coil	652..714	CDD:269868	32/61 (52%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	656..675		17/18 (94%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	682..696		4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7244
eggNOG	1	0.900	-	-		E1_KOG3863
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1095280at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41414
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4312
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.910