Protein Alignment cnc and NFE2

DIOPT Version :10

• Sequence 1: NP_001262864.1
• Gene: cnc / 42743
• FlyBaseID: FBgn0262975
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_006154.1
• Gene: NFE2 / 4778
• HGNCID: 7780
• Length: 373
• Species: Homo sapiens
• Alignment Length: 381
• Identity: 121/381 - (31%)
• Similarity: 179/381 - (46%)
• Gaps: 60/381 - (15%)

  Fly   947 RVPSLSDGEWGEGSDSAQDYH-----QGKYGGPYDFSYNNNSRLSTATRQPPVAQKKHQLYGKRD 1006
            ||..||..|.||...:.|:..     || ...|.:.|:...:........||.......::
Human    12 RVIQLSTSELGEMELTWQEIMSITELQG-LNAPSEPSFEPQAPAPYLGPPPPTTYCPCSIH---- 71

  Fly  1007 PHKQTPSALPPTAPPAAATAVQSQSIKYEYDAGYAS-----SGMASGGISEPGAM-------GPA 1059
            |....|...||...||:.:.|......|...|...|     ||:.|..:.:|.|:       ||.
Human    72 PDSGFPLPPPPYELPASTSHVPDPPYSYGNMAIPVSKPLSLSGLLSEPLQDPLALLDIGLPAGPP 136

  Fly  1060 LSKDYHHHQPYGMGASGSAFSGDYT---------VRPSPRTSQ--DLVQLNHTYSLPQGSGSLPR 1113
                    :|.....|.|..|.:|:         .....|.|:  ::..:.:.|||      :|.
Human   137 --------KPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEYPYSL------MPN 187

  Fly  1114 PQARDKKPLVATKT-----ASKGASAGNSSSVGGNSSNLEEEHLTRDEKRARSLNIPISVPDIIN 1173
            ..|.....|.|.:|     .|.|......::.|        |..:|||:||.::.||.....|:|
Human   188 SLAHSNYTLPAAETPLALEPSSGPVRAKPTARG--------EAGSRDERRALAMKIPFPTDKIVN 244

  Fly  1174 LPMDEFNERLSKYDLSENQLSLIRDIRRRGKNKVAAQNCRKRKLDQILTLEDEVNAVVKRKTQLN 1238
            ||:|:|||.|::|.|:|:||:|:|||||||||||||||||||||:.|:.||.|:..:...:.:|.
Human   245 LPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLTNERERLL 309

  Fly  1239 QDRDHLESERKRISNKFAMLHRHVFQYLRDPEGNPCSPADYSLQQAADGSVYLLPR 1294
            :.|...:...:.:..:...|:|.:||:|||..||..||.:|:|||||||:::|:||
Human   310 RARGEADRTLEVMRQQLTELYRDIFQHLRDESGNSYSPEEYALQQAADGTIFLVPR 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnc	NP_001262864.1	bZIP_CNC	1192..1259	CDD:269846	30/66 (45%)
		coiled coil	1193..1255	CDD:269846	29/61 (48%)
NFE2	NP_006154.1	Transactivation domain	1..206		46/212 (22%)
		Required for interaction with MAPK8. /evidence=ECO:0000250	1..83		17/75 (23%)
		PXY motif 1	61..65		2/3 (67%)
		PXY motif 2	79..83		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..150		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	205..226		4/28 (14%)
		bZIP_NFE2-like	263..330	CDD:269868	30/66 (45%)
		coiled coil	264..326	CDD:269868	29/61 (48%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	268..287		18/18 (100%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	291..298		3/6 (50%)