DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cnc and nfe2l1a

DIOPT Version :9

Sequence 1:	NP_001262864.1	Gene:	cnc / 42743	FlyBaseID:	FBgn0262975	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_998020.2	Gene:	nfe2l1a / 405781	ZFINID:	ZDB-GENE-040630-5	Length:	707	Species:	Danio rerio

Alignment Length:	595	Identity:	153/595 - (25%)
Similarity:	228/595 - (38%)	Gaps:	143/595 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   752 PHHAAMLHHPNAALGDICPTGQPHYGHNLGSAVTSSMHLTNSSHEADGAAAAAAAYKVEHDLMYY 816
            |.|..||..      |:..:| ...|.:|...:.||: |:....|..|.....|.   ||.|.:.
Zfish   223 PFHNQMLEE------DLELSG-VRDGSSLWPLIDSSL-LSEEDPELTGPGVQNAG---EHALQFQ 276

  Fly   817 GNTSSDI--NQTDGFINSIFTDEDLHLMDMNESFCRMVDNSTSNNSSVLGLPS-----SGHVSNG 874
            .:..|.:  .|...|.......:.|.:|:      ..|.|:|......||..|     :|.:.|.
Zfish   277 RSLISPLLPEQESTFSLEQQWQDVLSIME------SQVMNTTETIEDSLGNISDSDRNTGSIENV 335

  Fly   875 SGSSAQLGAGNPHGNQA---------NGASGGVGSMSGSAVGAGATGMTADLLASGGAGAQGGAD 930
            ......|       |||         |.....:...:.|...|.......:||.:.|:......|
Zfish   336 IHQDISL-------NQATLPRFPETPNSTMPNINLDTSSNAEAFEDSDIIELLMNAGSDLPSPLD 393

  Fly   931 RL--DASSDS-AVSSMGSERVPSLSDGEWGEG-SDS--AQDYHQGKYG--GPYDFSYNNNSRLST 987
            .|  :|..|. |:..:|.|.:......|..:. |||  :.||.|....  |....|.:::|..|:
Zfish   394 PLLEEAMLDEIALMDLGLEELGQTQFEEQNQADSDSGLSLDYSQSPSSPCGSESSSSSSSSSCSS 458

  Fly   988 ATRQPPVAQKKHQLYGKRDPHKQTPSALPPTAPPAAATAVQSQSIKYEYDAGYASSGMASGGISE 1052
            ::     :...|.|....|                   ||....||.|       .|...|.:.|
Zfish   459 SS-----SNSTHSLVPDED-------------------AVGYSHIKEE-------DGAVGGFMPE 492

  Fly  1053 PGAM--GPALSKDYHHHQPYGMGASGSAFSGDYTVRPSPRTSQDLVQLNHTYSLPQGSGSLPRPQ 1115
            ...|  ...|.....|..|                      ..:.:..:|||:         :||
Zfish   493 QTKMCQSSFLETRQFHRLP----------------------CLEHIGHDHTYN---------QPQ 526

  Fly  1116 ARDKKPLVATKTASKGASAGNSSSVGGNSSNLEEEHL-TRDEKRARSLNIPISVPDIINLPMDEF 1179
            ::.|.|    |...:.::..|:.           ||| :|||||||.:|||.|...||||.:|||
Zfish   527 SQRKPP----KDFFEESTEDNAL-----------EHLSSRDEKRARLMNIPFSNERIINLNVDEF 576

  Fly  1180 NERLSKYDLSENQLSLIRDIRRRGKNKVAAQNCRKRKLDQILTLEDEVNAVVKRKTQLNQDRDHL 1244
            |..|.||.|||.||:||||||||||||:||||||:||||.::.||..|:::.:.:.:|.:::..:
Zfish   577 NRLLEKYHLSEAQLTLIRDIRRRGKNKMAAQNCRRRKLDVLVELEHGVDSLRRLRAKLLREKSEI 641

  Fly  1245 ESERKRISNKFAMLHRHVFQYLRDPEGNPCSPADYSLQQAADGSVYLLPREKSEGNNTATAASNA 1309
            ....|.:..:...|:..|::.||:.:|......:::|||               |.....|:.|.
Zfish   642 SCSIKEVKQRLNSLYEEVYERLREEQGLLYCDNNFTLQQ---------------GRTRNAASQNR 691

  Fly  1310 VSSASGGSLN 1319
            ..|.|...|:
Zfish   692 SDSQSRRKLS 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnc	NP_001262864.1	bZIP_CNC	1192..1259	CDD:269846	29/66 (44%)
cnc	NP_001262864.1	coiled coil	1193..1255	CDD:269846	28/61 (46%)
nfe2l1a	NP_998020.2	bZIP_NFE2-like	589..656	CDD:269868	29/66 (44%)
nfe2l1a	NP_998020.2	coiled coil	590..652	CDD:269868	28/61 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7252
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3907
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1095280at2759
OrthoFinder	1	1.000	-	-		FOG0002254
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.070