DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cnc and Nfe2l2

DIOPT Version :9

Sequence 1:	NP_001262864.1	Gene:	cnc / 42743	FlyBaseID:	FBgn0262975	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_035032.1	Gene:	Nfe2l2 / 18024	MGIID:	108420	Length:	597	Species:	Mus musculus

Alignment Length:	650	Identity:	176/650 - (27%)
Similarity:	261/650 - (40%)	Gaps:	203/650 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 YQASPSNG--APGTPGQHGQYGSGANATLQPPPPPPPPHHAAMLHHPN----------AALGDIC 769
            :|.....|  .|..|.||.|..:..:|:           ::.:.|.|.          ..|.:..
Mouse    74 FQLDEETGEFLPIQPAQHIQTDTSGSAS-----------YSQVAHIPKQDALYFEDCMQLLAETF 127

  Fly   770 PTGQPHYGHNLGSAVTSSMHLTNSSHEADGAAAAAAAYKVEHDLMYYGNTSSDINQTDGFINSIF 834
            |....|          .|:.|...||      |.::.:...|..... |:|.:...||  ::||
Mouse   128 PFVDDH----------ESLALDIPSH------AESSVFTAPHQAQSL-NSSLEAAMTD--LSSI- 172

  Fly   835 TDEDL-----HLMDMNESFCRMVDNSTSNNSSVLGLP-------SSGHVSNGSGSSAQLGAGNPH 887
             ::|:     .|..:.|..|...:|....:::.:..|       .|.:....|.||.:...||..
Mouse   173 -EQDMEQVWQELFSIPELQCLNTENKQLADTTAVPSPEATLTEMDSNYHFYSSISSLEKEVGNCG 236

  Fly   888 GNQANGASGGVGSMSGSAVGAGATGMTADLLASGGAG-----------AQGGADRLDASSDSAVS 941
            .:..:|......|:..:...:..|.:.::...:...|           :.||:    ..|.:|:|
Mouse   237 PHFLHGFEDSFSSILSTDDASQLTSLDSNPTLNTDFGDEFYSAFIAEPSDGGS----MPSSAAIS 297

  Fly   942 SMGSERVPSLSDGEWGEGSDSA--QDYHQGKYGGPYDFSYNNNSRLSTATRQPPVAQKKH----Q 1000
            ...||    |.||.. ||.|.:  :.::.....|..:|: :::|.:|..| .|..|..:|    .
Mouse   298 QSLSE----LLDGTI-EGCDLSLCKAFNPKHAEGTMEFN-DSDSGISLNT-SPSRASPEHSVESS 355

  Fly  1001 LYGKRDPHKQTPSALPPTAPPAAATAVQSQSIKYEYDAGYASSGM-----ASGGISEPGAMG-PA 1059
            :||  ||            ||                 |::.|.|     |.|.:.:.|... ||
Mouse   356 IYG--DP------------PP-----------------GFSDSEMEELDSAPGSVKQNGPKAQPA 389

  Fly  1060 LSKDYHHHQPYGMGASGSAFSGDYTVRP-SP--------RTSQDLVQLNHTYSLPQGSGSLPRPQ 1115
                   |.|           || ||:| ||        |.||  .:......:|...|....|.
Mouse   390 -------HSP-----------GD-TVQPLSPAQGHSAPMRESQ--CENTTKKEVPVSPGHQKAPF 433

  Fly  1116 ARDKKPLVATKTASKGASAGNSSSVGGNSSNLEEEHLTRDEKRARSLNIPISVPDIINLPMDEFN 1180
            .:||                       :||.| |.||||||.||::|:||..|..|||||:|:||
Mouse   434 TKDK-----------------------HSSRL-EAHLTRDELRAKALHIPFPVEKIINLPVDDFN 474

  Fly  1181 ERLSKYDLSENQLSLIRDIRRRGKNKVAAQNCRKRKLDQILTLEDEVNAVVKRKTQLNQDRDHLE 1245
            |.:||...:|.||:|||||||||||||||||||||||:.|:.||              ||..||:
Mouse   475 EMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELE--------------QDLGHLK 525

  Fly  1246 SERKR--------------ISNKFAMLHRHVFQYLRDPEGNPCSPADYSLQQAADGSVYLLPREK 1296
            .||::              :..:.:.|:..||..|||.:|.|.||::|||||..||:|:|:|:.|
Mouse   526 DEREKLLREKGENDRNLHLLKRRLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSK 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnc	NP_001262864.1	bZIP_CNC	1192..1259	CDD:269846	34/80 (43%)
cnc	NP_001262864.1	coiled coil	1193..1255	CDD:269846	33/75 (44%)
Nfe2l2	NP_035032.1	DLG motif. /evidence=ECO:0000305\|PubMed:15581590, ECO:0000305\|PubMed:16581765, ECO:0000305\|PubMed:16790436	29..31
		ETGE motif. /evidence=ECO:0000305\|PubMed:15282312, ECO:0000305\|PubMed:16581765, ECO:0000305\|PubMed:16790436	79..82		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..440		38/189 (20%)
		bZIP_NFE2-like	486..553	CDD:269868	34/80 (43%)
		coiled coil	487..549	CDD:269868	33/75 (44%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	491..510		18/18 (100%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	514..521		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..597		14/27 (52%)
		Mediates interaction with CHD6 and is necessary to activate transcription. /evidence=ECO:0000250\|UniProtKB:O54968	583..588		2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7214
eggNOG	1	0.900	-	-		E1_KOG3863
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002254
OrthoInspector	1	1.000	-	-		otm43467
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4312
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.900