DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cnc and Bach2

DIOPT Version :9

Sequence 1:	NP_001262864.1	Gene:	cnc / 42743	FlyBaseID:	FBgn0262975	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_006537629.1	Gene:	Bach2 / 12014	MGIID:	894679	Length:	846	Species:	Mus musculus

Alignment Length:	744	Identity:	169/744 - (22%)
Similarity:	235/744 - (31%)	Gaps:	303/744 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   712 YPGY-SYQ--------ASPSNGAPG--------TPGQHGQYG----------------------- 736
            ||.| .||        ::||:|..|        :||...:.|
Mouse   234 YPRYKKYQLACTKNVYSAPSHGTSGFASTFSEDSPGNSLKPGLPMGQIKSEPPSEETEEESITLC 298

  Fly   737 -SGANATL------------QPPPPPPP--PHHAAMLHHPNAALGDIC------------PTGQP 774
             ||....:            ||.|.|.|  |..||.|....:.....|            .||.|
Mouse   299 LSGDETDIKDRPGDVEMDRKQPSPAPTPSTPTGAACLDRSRSVSSPSCLRSLFGITKGVESTGLP 363

  Fly   775 HYGHNLGSAVTSSMHLTNSSHEADGAAAAAAAYKVEHDLMYYGNTSSDINQTDGFINSIFTDEDL 839
            .         ||...|..||         |..:            :..|:|.|  :.:.:|
Mouse   364 S---------TSQQPLVRSS---------ACPF------------NKGISQGD--LKTDYT---- 392

  Fly   840 HLMDMNESFCRMVDNSTSNNSSVLGLPSSGHVSNGSGSSAQLGAGNPHGNQANGASGGVGSMSGS 904
                                      |.:|:.            |.||..|.:        :|..
Mouse   393 --------------------------PLAGNY------------GQPHVGQKD--------VSNF 411

  Fly   905 AVGAGATGMTADLLASGGAGAQGGADR----LDAS----------SDSAVSSMG---SERVP-SL 951
            |:|:...|...:.|..    .:|..||    ..||          |.||||::.   ||.|| ||
Mouse   412 AMGSPLRGPGPETLCK----QEGELDRRSVIFSASACDQPNTPVHSYSAVSNLDKDLSEPVPKSL 472

  Fly   952 SDGEWGEGSDSAQDY-HQGKYGGPYDFSYNNNSRLSTATRQPPVAQKKHQLYGKRDPHKQTPSAL 1015
            ..|. |:...|:|.| |.|...                          ..|.|:..|:...|..:
Mouse   473 WVGA-GQSLPSSQAYSHSGLMA--------------------------DHLPGRIRPNTSCPVPI 510

  Fly  1016 P--PTAPP-AAATAVQSQSIKYEYDAGYASSGMASGG----------ISEPGAMGPALSKDYHHH 1067
            .  |.:|| ...|...|....|    .||..|  |||          .|.|.:.| |......|.
Mouse   511 KVCPRSPPLETRTRTSSSCSSY----SYAEDG--SGGSPCSLPLCEFSSSPCSQG-ARFLATEHQ 568

  Fly  1068 QPYGMGASGSAFSGDYT-VRPSPRTSQDLVQLNHTYSLPQGSGSLPRPQARDKKPLVATKTASKG 1131
            :|..||      .|.|. |||..:..|                                   |.|
Mouse   569 EPGLMG------DGMYNQVRPQIKCEQ-----------------------------------SYG 592

  Fly  1132 ASAGNSSSVGGNSSNLEEEHLTRDEKRARSLNIPISVPDIINLPMDEFNERLSKYDLSENQLSLI 1196
            .   |||...|:.|..:.|.....: |.:.:.:|..|..|.:||.::|...:..:.|:..||..|
Mouse   593 T---NSSDESGSFSEADSESCPVQD-RGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFI 653

  Fly  1197 RDIRRRGKNKVAAQNCRKRKLDQILTLEDEVNAVVKRKTQLNQDRDHLESERKRISNKFAMLHRH 1261
            .|||||.||::|||.|||||||.|..||.|:..:|..|.:|..:|:||::....:.:.|:.|.:.
Mouse   654 HDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSCLSQE 718

  Fly  1262 VFQYLRDPE------------------GNPCSPADYSLQQ-------AADGSV--YLLPREKSEG 1299
            |.:.::.||                  |...:|....::|       |..|||  .|.|.....|
Mouse   719 VCRDIQSPEQIQALHRYCPVLIPMDLPGASVNPPPVGVEQSLAPSPCAVGGSVPCCLEPGAAPPG 783

  Fly  1300 -----NNTATAASNAVSSASGGSLNGHVP 1323
                 :||:.      :..||..|.|..|
Mouse   784 LPWVPSNTSE------NCTSGRRLEGSDP 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnc	NP_001262864.1	bZIP_CNC	1192..1259	CDD:269846	31/66 (47%)
cnc	NP_001262864.1	coiled coil	1193..1255	CDD:269846	29/61 (48%)
Bach2	XP_006537629.1	BTB_POZ_BACH2	13..136	CDD:349587
		bZIP_BACH	646..716	CDD:269867	31/69 (45%)
		coiled coil	655..706	CDD:269867	27/50 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3863
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900