Protein Alignment Irk1 and Kcnj13

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_446060.1
• Gene: Kcnj13 / 94341
• RGDID: 621661
• Length: 360
• Species: Rattus norvegicus
• Alignment Length: 334
• Identity: 125/334 - (37%)
• Similarity: 194/334 - (58%)
• Gaps: 19/334 - (5%)

  Fly   137 SRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWW 201
            |:|.| |:|.|.|. :.:|.:.|:|...||:|.:..|:|.:|||.:|||:||||..|..|..:|:
  Rat    14 SQRYR-RMVTKDGH-STLQMDGAQRGLVYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWY 76

  Fly   202 IIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEA 266
            .:|..:.|||..:  :..|:     .||:||..:::..:||.:|:|||.|||||..:.:.:||.|
  Rat    77 AVAEMNGDLEIDH--DVPPE-----NHTICVKHITSFTAAFSFSLETQLTIGYGTMFPSGDCPSA 134

  Fly   267 IFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHI 331
            |..:.||.:.|:.::||:.|...||::|||.||.::.|:..||:.|:||.|.|:|:|.:.|.|.:
  Rat   135 IALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDLAVVAHKDGKPNLIFQVANTRPSPL 199

  Fly   332 IEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADG--GEDRLMFIWPTTIVHKIDRNSPLYMLSAS 394
            ....|.|.:.:::  :.||:   ||..:....||  .|:...||:|.|..|.|..:|||..|...
  Rat   200 TSVRVSAVLYQER--ENGEL---YQTSVDFHLDGISSEECPFFIFPLTYYHTITPSSPLATLLQH 259

  Fly   395 DMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTY 459
            : ....||:||.|..:.|.||...|.|:||||||::..|||..::: |...|||:|....|:.|.
  Rat   260 E-TPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHRFAALMT-RGSKGEYQVKMENFDKTV 322

  Fly   460 -DVDTPLCS 467
             :..||:.|
  Rat   323 PEHPTPVVS 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	56/149 (38%)
		IRK_C	302..476	CDD:465439	60/169 (36%)
Kcnj13	NP_446060.1	IRK	21..163	CDD:460023	56/149 (38%)
		Selectivity filter. /evidence=ECO:0000305	119..124		4/4 (100%)
		IRK_C	170..331	CDD:465439	59/167 (35%)