Protein Alignment Irk1 and kcnj5

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_700619.4
• Gene: kcnj5 / 571888
• ZFINID: ZDB-GENE-120215-97
• Length: 425
• Species: Danio rerio
• Alignment Length: 417
• Identity: 189/417 - (45%)
• Similarity: 260/417 - (62%)
• Gaps: 19/417 - (4%)

  Fly   112 QIRRSIKAVSESPGPLTRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDA 176
            |:::..|.:.||..|..|........::.|:|.|.|.|:|||..||| |...|||.|:||||||.
Zfish    22 QVKKLPKHLRESQIPTDRTHLISDPVKKPRQRYVQKDGKCNVHHGNV-KETYRYLSDLFTTLVDL 85

  Fly   177 QWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSA 241
            :||.:..:|...:|.:|.||||:||:||....||.:::.:..:|          ||..:::.:||
Zfish    86 RWRLSFFIFTLVYVVNWLFFGFLWWLIALIRGDLLHSDEEGWTP----------CVENLNSFVSA 140

  Fly   242 FLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSR 306
            ||:|:||:||||||.|.:||:|||.|..:.:|.|.|..:.|.|||.:|.|:|:||.||:||:||.
Zfish   141 FLFSIETETTIGYGYRVITEKCPEGIILLMVQAILGSIVNAMMVGCMFVKISQPKNRAETLMFSH 205

  Fly   307 NAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLM 371
            ||||..||...||||||||:|.|||:||.:||::||.:.|||||.:|..|.:::||.|.|:|||.
Zfish   206 NAVISVRDNKMCLMFRVGDLRNSHIVEASIRAKLIRSQQTKEGEFIPLNQTDINIGFDTGDDRLF 270

  Fly   372 FIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFV 436
            .:.|..|.|:|:..||.:.:|.:.|.||.||:||:|||::|:||||.|||||||.||||||.||.
Zfish   271 LVSPLIISHEINEKSPFWEMSRAQMEKEEFEIVVILEGMVEATGMTCQARSSYLDSEVLWGFRFT 335

  Fly   437 NVVSFRKETGEYEVDYTLFNNTYDVDTPLCSAKQLDELKSEYSKSAKCVNAPFADRTLSASL--- 498
            .|:|..|  |.|||||..|::.|:.:||.||||   ||.:...:|....:.|.....|.|..
Zfish   336 PVLSLEK--GFYEVDYNNFHDIYETNTPTCSAK---ELSARLKESPLLPHLPLLSPDLRAHTTDP 395

  Fly   499 FQRIASAASVDHLDPASDESLDSGRLQ 525
            ||.....|..|...|....:..:.||:
Zfish   396 FQTTEDQAKHDADTPPETNNGSANRLE 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	68/149 (46%)
		IRK_C	302..476	CDD:465439	97/173 (56%)
kcnj5	XP_700619.4	IRK	55..194	CDD:460023	68/149 (46%)
		IRK_C	201..368	CDD:465439	95/171 (56%)