Protein Alignment Irk1 and kcnj19a

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_698251.1
• Gene: kcnj19a / 569752
• ZFINID: ZDB-GENE-060503-706
• Length: 504
• Species: Danio rerio
• Alignment Length: 419
• Identity: 177/419 - (42%)
• Similarity: 255/419 - (60%)
• Gaps: 40/419 - (9%)

  Fly   131 RQTRFSS---RRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFS 192
            |...|||   ::.|:|.|.|:|.|||..||:.....|||.|:||||||.:|||.||:|..::..:
Zfish    19 RGATFSSAPVKKKRQRFVEKNGRCNVQHGNLGGETSRYLSDLFTTLVDLKWRWNLLIFILTYTIA 83

  Fly   193 WAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNR 257
            |.....:||||||...||.:.:          :.::|.||..|.|..||||:.:||:.|||||.|
Zfish    84 WLVMASMWWIIAYIRGDLNHGH----------DASYTPCVANVYNFPSAFLFFIETEATIGYGYR 138

  Fly   258 YVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFR 322
            |:||:|||.|.....|.:.|..:.||::|.:|.|:|:|||||:||:||::|||..|||..|||||
Zfish   139 YITEKCPEGIILFLFQSLLGSIVDAFLIGCMFIKMSQPKKRAETLMFSQDAVISQRDGKLCLMFR 203

  Fly   323 VGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSP 387
            ||::|.||::.|.:|.::|:.:.|.|||.||..|.||.:|...|.|:|..:.|.||.|:|:..||
Zfish   204 VGNLRNSHMVSAQIRCKLIKSRQTPEGEFLPLDQCELDVGFGTGADQLFLVSPLTICHEINPKSP 268

  Fly   388 LYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDY 452
            .:.||...::.|:||:||:|||::|:||||.|||:||...||||||||:.|:|.  |.|.:.|||
Zfish   269 FFDLSQRSLMNEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFLPVMSL--EEGFFRVDY 331

  Fly   453 TLFNNTYDVDTPLCSAKQLDELKSEYSKSAKCVNAPFADRTLSASLFQRIASAASVDHLDPASDE 517
            :.|::|::|.||..|.|:.:|..|..|.    :..|..:|..            |:|.|: |.||
Zfish   332 SQFHSTFEVPTPPYSVKEYEEKSSLPSP----LLTPHRERVF------------SMDCLE-AGDE 379

  Fly   518 SLDSGRLQIRSHSIPNGVLASELEPLNNN 546
            .|..|....:        |.|:|:.::::
Zfish   380 GLHPGSASCK--------LPSKLQKMSSS 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	65/149 (44%)
		IRK_C	302..476	CDD:465439	85/173 (49%)
kcnj19a	XP_698251.1	IRK	36..176	CDD:460023	65/149 (44%)
		IRK_C	183..353	CDD:465439	84/171 (49%)