Protein Alignment Irk1 and kcnj12a

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_005162964.1
• Gene: kcnj12a / 569146
• ZFINID: ZDB-GENE-131126-14
• Length: 437
• Species: Danio rerio
• Alignment Length: 413
• Identity: 193/413 - (46%)
• Similarity: 255/413 - (61%)
• Gaps: 52/413 - (12%)

  Fly    64 GEQSAVCLEDTYKRTSTYASNINSTGGESSGSGTQLSRKESILGSFHRQIRRSIKAVSESPGPLT 128
            |..|.|..|:...|.:|      ..||..:|.|.         |..|
Zfish     7 GRYSIVSTEEDGLRLTT------MHGGGMNGYGN---------GKIH------------------ 38

  Fly   129 RYRQTRFSSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSW 193
                ||   |:.|.|.|.|:|:|||...|:.::.:||:.|||||.||.:||:.|:||...||.||
Zfish    39 ----TR---RKSRNRFVKKNGQCNVQFTNMDEKSQRYMADIFTTCVDIRWRYMLIVFTLVFVISW 96

  Fly   194 AFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRY 258
            ..||..:|:||..|.||:     |.:.|    ...|.||.||:..::|||:|:|||||||||.|.
Zfish    97 LAFGLAFWVIALLHGDLD-----NPAGD----DNFTPCVLQVNGFIAAFLFSIETQTTIGYGFRC 152

  Fly   259 VTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRV 323
            ||||||.|:|.:..|.|.|..|..||:|.:.||::||||||||||||.||||..|||..|||:||
Zfish   153 VTEECPLAVFLVVFQSIVGSIIDCFMIGAIMAKMARPKKRAQTLLFSHNAVIAMRDGKLCLMWRV 217

  Fly   324 GDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPL 388
            |::|||||:|||||||:|:.:||.|||.:|..|.::::|.|.|.||:..:.|.||:|:||..|||
Zfish   218 GNLRKSHIVEAHVRAQLIKPRVTTEGEYIPLDQLDINVGFDKGLDRIFLVSPITILHQIDHESPL 282

  Fly   389 YMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYT 453
            :.:|..|:....||:||:|||::|:|.||.|||||||.||:||||||..|:.  :|..:|:|||:
Zfish   283 FGISKQDLETADFEIVVILEGMVEATAMTAQARSSYLASEILWGHRFEPVLF--EEKNQYKVDYS 345

  Fly   454 LFNNTYDV-DTPLCSAKQLDELK 475
            .|:.||:| .||.||||.:.|.|
Zfish   346 HFHKTYEVPSTPRCSAKDMMENK 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	71/149 (48%)
		IRK_C	302..476	CDD:465439	97/175 (55%)
kcnj12a	XP_005162964.1	IRK_N	1..47	CDD:462486	16/79 (20%)
		IRK	48..189	CDD:460023	71/149 (48%)
		IRK_C	196..369	CDD:465439	97/175 (55%)