Protein Alignment Irk1 and kcnj1a.5

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_001038634.2
• Gene: kcnj1a.5 / 568823
• ZFINID: ZDB-GENE-050420-120
• Length: 370
• Species: Danio rerio
• Alignment Length: 380
• Identity: 141/380 - (37%)
• Similarity: 216/380 - (56%)
• Gaps: 34/380 - (8%)

  Fly   127 LTRYRQTRFS----SRRVRK-RVVFKHGECNVVQGNVA-KRRRRYLQDIFTTLVDAQWRWTLLVF 185
            :||..:.||.    .||:|| |:|.|.|.||:..|||. |....|:.|.:||||:.:||:.||.|
Zfish     1 MTRSLRQRFKDYRLERRIRKNRLVTKDGHCNIEFGNVLHKNGFAYVLDFWTTLVETRWRFILLYF 65

  Fly   186 AASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQT 250
            .||:..||..||.:|:.:|..:.||.:   :|..||      |..|...|::|.:|||.::||||
Zfish    66 VASYSLSWLIFGLLWYWLARNNGDLYW---QNPPPD------HKPCAINVNDMTNAFLNALETQT 121

  Fly   251 TIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDG 315
            .:|.||.:||:.||.::..:.||.:.|:||..|..|||..|::.|||||:|:.||::||||.:.|
Zfish   122 GMGCGNLFVTDLCPGSVAVLTIQMVVGLFIGIFWCGIVMTKITLPKKRAKTITFSKSAVICPKKG 186

  Fly   316 VPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVH 380
            ..||..||.::||:.:|.:.:..:::|..|| .||.:...|..:....|.|:|.|.|:.|.|:.|
Zfish   187 TLCLQIRVANLRKTLMIGSQIYGKLLRTTVT-GGETVILDQVSIDFMVDAGKDNLFFMCPLTLYH 250

  Fly   381 KIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKET 445
            .||::||.:.::...:.::.||:||.|:|:.|||..:.|.|:||:|.|::||:.|:.::|..||.
Zfish   251 IIDKSSPFFDMAVDTLHQQDFELVVFLDGMDESTSSSCQVRTSYIPREIMWGYDFLPIISRSKER 315

  Fly   446 GEYEVDYTLFNNTYDVDTPLCS-----------------AKQLDELKSEYSKSAK 483
             .|.||::.......|.|..||                 .|.::....|..||.|
Zfish   316 -RYRVDFSNIAKVVPVPTAHCSRCYHNEPGNHLHLHGTDTKSVEVFDMELPKSTK 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	61/150 (41%)
		IRK_C	302..476	CDD:465439	61/190 (32%)
kcnj1a.5	NP_001038634.2	IRK	24..166	CDD:460023	61/150 (41%)
		IRK_C	173..342	CDD:465439	60/170 (35%)