Protein Alignment Irk1 and kcnj2a

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_001318145.1
• Gene: kcnj2a / 564522
• ZFINID: ZDB-GENE-120319-1
• Length: 427
• Species: Danio rerio
• Alignment Length: 387
• Identity: 179/387 - (46%)
• Similarity: 249/387 - (64%)
• Gaps: 20/387 - (5%)

  Fly    96 GTQLSRKESILGSFHRQIRRSIKAVSESPGPLTRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAK 160
            |:..:.:.||:.|....::.:..||....|.......||   .:.:.|.|.|.|.|||...||::
Zfish     2 GSVRANRYSIVSSEEDGMKLATAAVPNGYGNGKSKVHTR---HQTQSRFVKKDGHCNVQFINVSE 63

  Fly   161 RRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVAN 225
            :.:|||.|||||.||.:|||..::|..:|:.||.|||.|:|::|..|.|||....|
Zfish    64 KSQRYLADIFTTCVDIRWRWMFVIFCLAFLLSWLFFGCIFWLVAIFHGDLENNGHK--------- 119

  Fly   226 ITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFA 290
                 ||:.||:..:|||:|:|||||||||.||||:|||.|:|.:..|.|.|..|.||::|.|.|
Zfish   120 -----CVSNVSSFTAAFLFSIETQTTIGYGYRYVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMA 179

  Fly   291 KLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFY 355
            |:::||||.:||:||.||.:..||...|||:|||::||||::|||||||::|.:.|.|||.:|..
Zfish   180 KMAKPKKRNETLVFSHNATVAMRDNKLCLMWRVGNLRKSHLVEAHVRAQLLRSRTTAEGEFIPLD 244

  Fly   356 QQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQA 420
            |.::.:|.|.|.||:..:.|.||||:||.:||.|.:|..:|....||:||:|||::|:|.||||.
Zfish   245 QMDIDVGFDSGIDRIFLVSPITIVHEIDEDSPFYDMSKQEMENSDFEIVVILEGMVEATAMTTQC 309

  Fly   421 RSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDV-DTPLCSAKQLDELKSEYSKS 481
            ||||:.:|:||.|||..|:.  :|...|:|||:.|:.||:| .||||||:.|.|.|...|.|
Zfish   310 RSSYVANEILWAHRFEPVLF--EEKNYYKVDYSRFHKTYEVPSTPLCSARDLAEKKYIISNS 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	72/149 (48%)
		IRK_C	302..476	CDD:465439	89/174 (51%)
kcnj2a	NP_001318145.1	IRK_N	1..47	CDD:462486	9/47 (19%)
		IRK	48..184	CDD:460023	72/149 (48%)
		IRK_C	191..364	CDD:465439	89/174 (51%)